Association between IL-4 polymorphism and acute rejection of solid organ allograft: A meta-analysis

Association of interleukin4 gene polymorphisms of recipients and donors with acute rejection following living donor liver transplantation

“…IL-4 blocks macrophage activation and inhibits the production of Th1 cytokines such as IL-1 and tumor necrosis factor-␣ [1,18,38]. Several studies have investigated the risk of recipient IL4 polymorphisms on acute rejection of allografts in kidney or heart transplantation [1,[8][9][10][16][17][18]. The TT genotype of IL4-33 is reported to be associated with high production of IL-4 [4,15].…”

“…Cytokine genotypes have been previously studied in patients who have undergone solid organ transplantation, and certain polymorphisms have been found to affect the development in graft rejection [1][2][3][4][5][6][7][8][9][10]. In the field of organ transplantation, pro-inflammatory Th1 cytokines are believed to be involved in acute transplant rejection, by directly contributing to graft damage.…”

“…Several studies have investigated the risk of recipient IL4 gene polymorphisms in acute rejection of allografts [1,[8][9][10]16,17]. In addition, studies have assessed the association of donor IL4 polymorphisms and acute rejection of solid organ allografts [9,10,17,18].…”

“…In addition, studies have assessed the association of donor IL4 polymorphisms and acute rejection of solid organ allografts [9,10,17,18]. Poole et al demonstrated a significant decrease in the donor IL4T positive genotype (T/T + C/T) of T-590C in the rejecter group of renal transplantation [17].…”

Genetic polymorphisms in the immune response: A focus on kidney transplantation

“…Wu et al performed a meta-analysis of loci in the IL4 gene, limiting to studies reporting acute rejection, and explored various modes of inheritance (multiplicative model, Cochrane Armitage test for trend, dominant and recessive models) [56]. Pooled analyses (including heart, liver and kidney transplant) revealed no association for recipient IL4 rs2243250 (−590 C/T) (492 cases and 721 controls; 7 studies of kidney, 2 of liver and 1 of heart transplants); recipient IL4 rs2070874 (−33C/T) (98 cases and 220 controls; 2 studies in kidney, 1 in liver); and donor IL4 rs2243250 (− 590 C/T; 298 cases and 390 controls; in kidney (n = 4 studies) 4 and heart (n = 1) transplants).…”