Association between IL-4 gene polymorphisms and chronic obstructive pulmonary disease of patients in Hebei province, China

Abstract

We aimed to study the association between IL-4 gene polymorphisms and chronic obstructive pulmonary disease (COPD) of patients in Hebei Province. The blood samples of 62 COPD patients and 301 healthy subjects were collected. IL-4 gene polymorphisms were detected by PCR with sequence-specific primer typing. There were significant differences in the alleles of IL-4-33, IL-4-590 and IL-4-1098 between COPD patients and healthy subjects (P<0.05). IL-4-590/C (P<0.001, OR = 4.619, CI = 1.640-7.985) had the highest susceptibility, suggesting that people with this allele were 3.6 times more prone to COPD than those with IL-4-33-590/T allele. COPD of susceptible patients was positively associated with IL-4-33/C: