Association between IL‐17F Gene Polymorphisms and Susceptibility to and Severity of Rheumatoid Arthritis (RA)

Abstract

Interleukin‐17F (IL‐17F) is a novel proinflammatory cytokine. IL‐17F gene is an excellent candidate for chronic inflammatory disease. We investigated the association between rheumatoid arthritis (RA) and His161Arg (7488A/G; rs763780) and Glu126Gly (7383A/G; rs2397084) polymorphism of IL‐17F gene. The gene polymorphisms in 220 Polish patients with RA and 106 healthy subjects were amplified by polymerase chain reaction with restriction endonuclease mapping. Overall, the polymorphisms of the IL‐17F gene were not correlated with susceptibility to RA in Polish population. However, the IL‐17F His161Arg variant was associated with parameters of disease activity, such as number of tender joints, HAQ score or DAS‐28‐CRP. Moreover, our findings have shown that Glu126Gly IL‐17F gene polymorphism may be correlated with longer disease duration in patients with RA. Our results for the first time showed the relationship between IL‐17F gene polymorphisms and severity of RA.

Genetic variation in key molecules of the Th-17 immune response is not associated with risk for prosthetic joint infection in a Czech population

“…Despite sufficiently high statistical power (see Table 2), none of the polymorphisms within IL17A, IL17F, IL4, IL12A, IL12B, IL23R, CXCL1, CXCL5 and CXCR2 genes affected susceptibility to PJI in our patients after TJA. In the case of IL17F polymorphism, however, we could have missed the genetic association with PJI because this polymorphism is relatively rare in Caucasian population 15 . The negative data on the association of both IL12B polymorphisms and CXCR2 polymorphism with PJI should be interpreted carefully as these polymorphisms did not comply with the Hardy-Weinberg equilibrium (HWE).…”

“…To strengthen our data, we recruited second control group (Czech population controls) and there was no difference in the distribution of 10 polymorphisms between the patients with PJI and the population controls without TJA. Moreover, the frequencies of the investigated polymorphisms within the IL17A, IL17F, IL4, IL12A, IL12B, IL23R, CXCL1, CXCL5 and CXCR2 genes corresponded to their distribution in other Caucasian populations [15][16][17][18][19][20][21] . Legend: Continuous data presented as median with interquartile (1st to 3rd) range in parentheses.…”

Association between Polymorphisms of Interleukin-17A and Interleukin-17F Genes and Silicosis Susceptibility in Chinese Han People

“…(Paradowska-Gorycka et al, 2010). So we investigated the relationship between the combined effect of IL-17A, IL-17F genotypes and silicosis.…”

Dual Inhibition of TNFR1 and IFNAR1 in Imiquimod-Induced Psoriasiform Skin Inflammation in Mice

“…This is very interesting, because the complex biology underlying a disease is often multifactorial and requires a multifaceted approach, which can be achieved by combination therapies. Blocking both TNFR1 and IFNAR1 reduces activation of the IL-23/IL-17 axis during IMQ-mediated skin inflammation through reduction of IL-12p40 and IL-17F levels, two novel drug targets in psoriasis, Crohn's disease, and rheumatoid arthritis (34,(64)(65)(66)(67)(68)(69).…”