Association between IgE-mediated allergies and diabetes mellitus type 1 in children and adolescents

Abstract

Our results suggest that T1DM is associated with a higher risk of a self-reported presence of IgE-mediated allergies and that the Th1/Th2-hypothesis may be an oversimplification.

Risk of allergic conjunctivitis in patients with type 1 diabetes mellitus: a population-based retrospective cohort study

“…9 In 2015, Klamt et al designed a prospective case-control study to investigate the association between the prevalence of T1DM and IgE-mediated allergies. 10 The results implied that T1DM is associated with an increased risk of self-reported IgE-mediated allergies. However, in a large prospective study involving 14 849 individuals from five study populations, including 834 cases with autoimmune disease, 11 Skaaby et al did not find a statistically significant association between atopy and the development of any autoimmune disease, including T1DM.…”

“…However, the results of recent studies investigating the association between the two diseases are controversial. [7][8][9][10][11] In 2011, Thomsen et al examined the association between T1DM and atopic diseases in a twin population registered in the Danish Twin Registry. 7 They found that the age-adjusted and sex-adjusted risk of atopic dermatitis was lower in patients with T1DM than in non-diabetics, whereas asthma and allergic rhinoconjunctivitis were non-significantly associated with T1DM.…”

“…[7][8][9][10][11] These conflicting results may be due to differences in the study design, patient characteristics and geographic location (which leads to variations in allergen exposure) as well as the influence of IL-17 producing T cells (Th17 cells), T regulatory cells (Tregs) and B lymphocytes in both disorders. Although…”

Reagin-Specific Response to Insulin Level in Carbohydrate Metabolism Disorders Is Dependent on the Blood Group Abo Antigenic Determinants

“…Это будет означать, что развитие IgE-опосредованной аллергии (Th2-путь) будет понижать риск развития СД1 [16]. Известно, что Th1-эффекторы CD4 + играют су-щественную роль в противовирусном иммуните-те [14].…”

“…В последнее время практически сформировалось воззрение, что усиление IgE-поликлонального ответа и противовоспалительных цитокинов считают маркером экспансии Th2 и развитием иммунной системы по аллергическому типу, что понижает риск развития сахарного диабета 1 типа (СД1). И наоборот, пациенты, болеющие СД1, мало подвержены аллергии [14]. Существует мне-ние, что у лиц с разными группами крови (АВ0) могут быть различия в индивидуальном уровне адаптивной реакции организма.…”