Association between <i>TLR</i>-9 gene rs187084 polymorphism and knee osteoarthritis in a Chinese population

Zheng, Mingfeng; Shi, Shiyuan; Zheng, Qi; Wang, Yifan; Ying, Xiaozhang; Jin, Yanghui

doi:10.1042/bsr20170844

Cited by 8 publications

(8 citation statements)

References 20 publications

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“…Associated with psoriatic arthritis risk 69 , hip and knee osteoarthritis 70,71 , SLE 72 and IBD 73 ; associated with the risk of autoimmune thyroid disease 74 ; response to anti-TNF therapy in patients with RA 64 34 and DNA samples were obtained from peripheral blood collected at the Statens Serum Institut (Copenhagen, Denmark), which routinely perform screening for tuberculosis before treatment with biological treatments. Healthy blood donors were recruited in Viborg and Sønderborg (Denmark).…”

Section: Ra Patient Populationsmentioning

confidence: 99%

NFKB2 polymorphisms associate with the risk of developing rheumatoid arthritis and response to TNF inhibitors: Results from the REPAIR consortium

Sánchez-Maldonado

Martínez-Bueno

Canhão

et al. 2020

Sci Rep

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This study sought to evaluate the association of 28 single nucleotide polymorphisms (SNPs) within NFKB and inflammasome pathway genes with the risk of rheumatoid arthritis (RA) and response to TNF inhibitors (TNFi). We conducted a case-control study in a European population of 1194 RA patients and 1328 healthy controls. The association of potentially interesting markers was validated with data from the DANBIO (695 RA patients and 978 healthy controls) and DREAM (882 RA patients) registries. The meta-analysis of our data with those from the DANBIO registry confirmed that anti-citrullinated protein

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Section: Ra Patient Populationsmentioning

confidence: 99%

NFKB2 polymorphisms associate with the risk of developing rheumatoid arthritis and response to TNF inhibitors: Results from the REPAIR consortium

Sánchez-Maldonado

Martínez-Bueno

Canhão

et al. 2020

Sci Rep

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“…Previously, all of the candidate gene association studies that have examined the relationship between TLR-9 and KOA found a significant relationship between rs187084 and the risk of KOA. Zheng et al (2017) and Balbaloglu et al (2017) both demonstrated that the CC genotype at rs187084 had a higher risk for KOA in Han Chinese individuals and Turks. However, a two-stage case-control study found that the TT genotype at rs187084 had a higher risk for KOA in a Han Chinese population from Taiwan (Su et al, 2012a).…”

Section: Discussionmentioning

confidence: 94%

“…With the rapid development of high-throughput sequencing, although more and more susceptibility variants of complex diseases have been identified (Guan et al, 2013(Guan et al, , 2014(Guan et al, , 2016a(Guan et al, , 2016b(Guan et al, , 2016cLiu et al, 2014;Zhang et al, 2018a). In recent years, researchers have identified strong association signals between the TLR-9 gene and the risk of KOA in both Han Chinese and Turkish populations (Su et al, 2012a;Balbaloglu et al, 2017;Zheng et al, 2017). For HOA, an important aspect of OA (the relationship of TLR-9 to the risk of HOA) remains largely unknown.…”

Section: Discussionmentioning

confidence: 99%

“…TLR-9 belongs to the TLR family, which is a group of transmembrane proteins that act as the primary receptors of innate immunity. Owing to the interaction with proinflammatory pathways through TLRs, the development of inflammatory diseases may occur with diseases, including cardiovascular diseases and OA (Zheng et al, 2017). Moreover, two independent studies have found that there was an association between TLR-9 and KOA among the Chinese population (Su et al, 2012b;Zheng et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the Relationship Between Common Variants in the TLR-9 Gene and Hip Osteoarthritis Susceptibility

Xiao

et al. 2019

Genetic Testing and Molecular Biomarkers

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Objective: Hip osteoarthritis (HOA) is one of the most common types of osteoarthritis and affects nearly 10% of men and 18% of women who are >60 years of age worldwide. It has been demonstrated to be a genetic disease with a 50% heritability risk. Recently, the TLR-9 gene has been associated with knee OA in both Turkish and Chinese populations, but the relationship between the TLR-9 gene and HOA has not been evaluated. In this study, we aimed to evaluate the relationship between the common genetic variants in the TLR-9 gene and the predisposition of Han Chinese individuals to HOA. Methods: A total of 730 HOA patients and 1220 healthy controls were recruited in a hospital-based case-control study. Six common single nucleotide polymorphisms (SNPs) of the TLR-9 gene were selected for genotyping, and genetic association analyses were performed using both single-marker and haplotype-based methods. Results: The SNP rs187084 was found to be significantly associated with the risk of HOA after a Bonferroni correction (adjusted allelic p-values with age, gender, and body mass index [BMI] = 0.0008). The results indicated that the A allele of rs187084 is a risk allele for HOA and is likely to be a predisposing factor leading to an increased risk of HOA (adjusted odds ratio with age, gender, and BMI = 1.26, 95% confidence interval = 1.10-1.43). The results of the haplotype analyses confirmed a similar pattern to the SNP analyses. Conclusions: Our study provides strong evidence that variations in the TLR-9 gene are closely linked with genetic susceptibility to HOA in the Han Chinese population. This finding furthers the role of TLR-9 in the development and occurrence of OA in general.

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“…Thus, atherogenesis might be triggered at early stages by the association of rs1898830 with decreased HDL-C and increased risk of HTN. Several studies have implicated certain TLRs polymorphisms with inflammatory diseases [ 28 , 29 , 30 ]. The SNP rs1898830, known as -15,607A/G, is in the first intron of the TLR2 gene.…”

Section: Discussionmentioning

confidence: 99%

The Association of rs1898830 in Toll-Like Receptor 2 with Lipids and Blood Pressure

Chedid

Salami

Shamieh

2020

JCDD

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Background and Objective: Toll-like receptors (TLRs) are important components of the innate immune system, involved in establishing immunity to infections. Apart from being implicated in immunity, numerous studies have reported that many TLRs, including TLR2, are involved in the pathogenesis of cardiovascular diseases and their risk factors. Since rs1898830 is associated with TLR2-mediated cellular activation, we aimed to study its association with CVD risk factors, such as lipid levels and hypertension. Methods: A cross-sectional study was conducted on 460 individuals free from chronic diseases. Clinical and biological data were collected and DNA was extracted and genotyped using Kompetitive allele specific PCR (KASP™). Multiple logistic regression models, adjusted for six covariates, were used. A power calculation analysis was also performed. Results: We found that rs1898830 in TLR2 was positively associated with hypertension (OR = 2.18, p = 0.03) and negatively associated with high-density lipoprotein cholesterol (OR = 0.66, p = 0.05). In contrast, no relation was found with total cholesterol and low-density lipoprotein cholesterol. Conclusion: The present results provide additional evidence supporting the implication of TLR2 in CVD risk factors.

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Association between TLR-9 gene rs187084 polymorphism and knee osteoarthritis in a Chinese population

Cited by 8 publications

References 20 publications

NFKB2 polymorphisms associate with the risk of developing rheumatoid arthritis and response to TNF inhibitors: Results from the REPAIR consortium

NFKB2 polymorphisms associate with the risk of developing rheumatoid arthritis and response to TNF inhibitors: Results from the REPAIR consortium

Evaluation of the Relationship Between Common Variants in the TLR-9 Gene and Hip Osteoarthritis Susceptibility

The Association of rs1898830 in Toll-Like Receptor 2 with Lipids and Blood Pressure

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