Association between <i>MTHFR</i> C677T polymorphism and folate, vitamin B12, homocysteine, and DNA fragmentation in patients with ovarian cancer

Ozkilic, Anıl; Çetin, Ahmet; Bayoğlu, Burcu; Balcı, Huriye; Cengiz, Müjgan

doi:10.1515/tjb-2016-0151

Cited by 3 publications

(4 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For North America and Australia, the rate is 8%-20%. The TT rate in Japan is 12% (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)24). The results of this study are in compliance with the frequency reported in white Turkish population.…”

Section: Discussionsupporting

confidence: 86%

See 1 more Smart Citation

Investigation of the Methylenetetrahydrofolate Reductase Gene C677T and A1298G Polymorphism in Chronic Periodontitis

Kocaman¹

2019

Erciyes Med J

View full text Add to dashboard Cite

Investigation of the Methylenetetrahydrofolate Reductase Gene C677T and A1298G Polymorphism in Chronic Periodontitis Objective: This case control study examined the frequency and distribution of the C677T and A1298C single-nucleotide polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene in Turkish patients with chronic periodontitis. Materials and Methods: This study included 89 subjects: 49 patients with chronic periodontitis and 40 healthy persons. Medical and periodontal histories were taken, and PD, CAL, PI, and BOP were recorded as the clinical parameters. The blood samples were taken from the subjects, and their DNA was obtained. The MTHFR gene's single nucleotide polymorphisms 677C→T and 1298A→C genotyping were analyzed using the RFLP assay, then PCR. Results: There was a significant difference between the groups except for age when the clinical findings. Single-nucleotide polymorphisms in the MTHFR gene C677T and 1298C regions were not found to be significantly different between the groups. Conclusion: The study revealed no association between the MTHFR polymorphism and the risk of chronic periodontitis; however, increasing the number of patients is useful when performing further studies. This present study is important because it is, to the best of our knowledge, the first study to research the interrelation between the MTHFR gene and chronic periodontitis.

show abstract

Section: Discussionsupporting

confidence: 86%

“…The MTHFR polymorphisms are important risk factors for the development of cancer, vascular diseases, and diabetes (17)(18)(19). A single gene polymorphism in the MTHFR gene is known to reduce the enzyme activity encoded from the gene.…”

Section: Discussionmentioning

confidence: 99%

Investigation of the Methylenetetrahydrofolate Reductase Gene C677T and A1298G Polymorphism in Chronic Periodontitis

Kocaman¹

2019

Erciyes Med J

View full text Add to dashboard Cite

show abstract

“…Finally, 27 case-control studies with 7856 ovarian and cervical cancer cases and 11,263 controls were included. Among these studies, eleven case-control studies with 4990 cases 7730 controls were on ovarian cancer (Jakubowska et al, 2007;Wu et al, 2007;Terry et al, 2010;Prasad and Wilkhoo, 2011;Webb et al, 2011;Gao et al, 2012;Pawlik et al, 2012;Zhang et al, 2012;Özkılıç et al, 2016) and 16 case-control studies with 2,866 cases 3,533 controls were on cervical cancer (Lambropoulos et al, 2003;Sull et al, 2004;Zoodsma et al, 2005;Kang et al, 2005;Delgado-Enciso et al, 2006;Ma et al, 2006;Shekari et al, 2008;Nandan et al, 2008;Kohaar et al, 2010;Tong et al, 2011;von Keyserling et al, 2011;Yang et al, 2011;Mostowska et al, 2011; Figure 1. The Flow Diagram of the Included and Excluded Studies = 0.202), and recessive (TT vs. TC+CC: OR = 1.110, 95% CI 0.876-1.406, p = 0.389).…”

Section: Characteristics Of Studiesmentioning

confidence: 99%

Association of MTHFR 677C>T Polymorphism with Susceptibility to Ovarian and Cervical Cancers: A Systematic Review and Meta-Analysis

Karimi-Zarchi

Moghimi

Abbasi

et al. 2019

Asian Pac J Cancer Prev

View full text Add to dashboard Cite

Background: Previous studies have evaluated the impact of MTHFR 677C>T polymorphism on susceptibility to ovarian and cervical cancers in women, but the conclusions are still controversial. To get a more precise evaluation of the association between MTHFR 677C>T polymorphism and risk of ovarian and cervical cancers, we performed a meta-analysis of the association of all eligible studies. Methods: A comprehensive search performed in PubMed, Google Scholar, CNKI, and Web of Science databases to identify the relevant studies up to October 15, 2018. The strength of the association was estimated by odds ratios (OR) with 95% confidence interval (CI). Results: A total of 27 case-control studies including eleven studies with 4990 cases 7730 controls on ovarian cancer and 16 studies with 4990 cases and 7730 controls on cervical cancer were selected. Pooled data revealed that the MTHFR 677C>T polymorphism not significantly associated with an increased risk of ovarian and cervical cancers under all five genetic models. However, stratified analysis by ethnicity showed that the MTHFR 677C>T polymorphism was significantly associated with risk of ovarian cancer in Asians. No publication bias was found in the current meta-analysis. Conclusions: The results of this meta-analysis proposes that the MTHFR 677C>T polymorphism may not play a role in development of ovarian and cervical cancers in overall population. Further well-designed studies are necessary to clarify the precise role of the MTHFR 677C>T polymorphism on ovarian and cervical cancers risk.

show abstract

“…MTHFR rs1801133, 97,127,128,129,130,131,132,133,134 rs1801131 97,129,132,135 MTR rs1805087 129,133 MTRR rs1801394 129,133 MUC16 rs2547065 125,136 NBS1 rs1063045, 9 rs1805794, 9 rs709816, 9 rs1061302 9 p16/CDKN2 rs11515, [137][138][139] PGR rs1042839, [140][141][142][143] rs1042838 , 98,140,142,143,144,145,146,147 The researches about Fok1 rs2228570 carried on Caucasian and Asian groups. Other gene models were based on Caucasian.…”

Section: Gene Snpsmentioning

confidence: 99%

The association between single nucleotide polymorphisms and ovarian cancer risk: A systematic review and network meta‐analysis

et al. 2022

Cancer Medicine

View full text Add to dashboard Cite

Background The relationship between single nucleotide polymorphisms (SNPs) and ovarian cancer (OC) risk remains controversial. This systematic review and network meta‐analysis was aimed to determine the association between SNPs and OC risk. Methods Several databases (PubMed, EMBASE, China National Knowledge Infrastructure, Wanfang databases, China Science and Technology Journal Database, and China Biology Medicine disc) were searched to summarize the association between SNPs and OC published throughout April 2021. Direct meta‐analysis was used to identify SNPs that could predict the incidence of OC. Ranking probability resulting from network meta‐analysis and the Thakkinstian’s algorithm was used to select the most appropriate gene model. The false positive report probability (FPRP) and Venice criteria were further tested for credible relationships. Subgroup analysis was also carried out to explore whether there are racial differences. Results A total of 63 genes and 92 SNPs were included in our study after careful consideration. Fok1 rs2228570 is likely a dominant risk factor for the development of OC compared to other selected genes. The dominant gene model of Fok1 rs2228570 (pooled OR = 1.158, 95% CI: 1.068–1.256) was determined to be the most suitable model with a FPRP <0.2 and moderate credibility. Conclusions Fok1 rs2228570 is closely linked to OC risk, and the dominant gene model is likely the most appropriate model for estimating OC susceptibility.

show abstract

Association between MTHFR C677T polymorphism and folate, vitamin B12, homocysteine, and DNA fragmentation in patients with ovarian cancer

Cited by 3 publications

References 28 publications

Investigation of the Methylenetetrahydrofolate Reductase Gene C677T and A1298G Polymorphism in Chronic Periodontitis

Investigation of the Methylenetetrahydrofolate Reductase Gene C677T and A1298G Polymorphism in Chronic Periodontitis

Association of MTHFR 677C>T Polymorphism with Susceptibility to Ovarian and Cervical Cancers: A Systematic Review and Meta-Analysis

The association between single nucleotide polymorphisms and ovarian cancer risk: A systematic review and network meta‐analysis

Contact Info

Product

Resources

About