Association between MMP-3 polymorphisms among Chinese patients with osteonecrosis of the femoral head

Abstract

Many potential causative factors are related to the initiation and progression of osteonecrosis of the femoral head (ONFH). The matrix metalloproteinase/tissue inhibitor of metalloproteinases (MMPs/TIMPs) system was found to play a significant role in the development of ONFH. The aim of this study is to investigate the association between polymorphisms of MMP-3 and ONFH in the Chinese population. We selected 8 single-nucleotide polymorphisms (SNPs) in 2 genes selected from the MMPs/TIMPs system in a case–control study with 585 cases of ONFH and 507 healthy controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using the chi-squared test, genetic model analysis, haplotype analysis, and stratification analysis. We found that the minor allele of rs650108 and rs522616 (p<0.05) was assumed a risk allele compared to the wild-type allele. In the genetic model analysis, We observed two susceptibility SNPs additionally: rs650108, dominant model analyses (with adjustment: OR=0.73; 95%CI 0.56-0.95; p=0.017) and additive model analyses (with adjustment: OR=0.83; 95%CI 0.70-0.99; p=0.044); and rs522616 recessive model analyses (with adjustment: OR=1.52; 95%CI 1.07-2.14; p=0.018) and additive model analyses (with adjustment: OR=1.21; 95% CI 1.02-1.44; p=0.033). Our results verify that genetic variants of MMP3 contribute to ONFH susceptibility in the population of northern China. In addition, we found that gender differences might interact with MMP3 polymorphisms to contribute to the overall susceptibility to ONFH.

Germline VWF/MPRIP and somatoplasm FGA variants synergically confer susceptibility to non-traumatic osteonecrosis of the femoral head

“…Theoretically, SOX9 might physically interact with RUNX2 and thereby inhibit osteogenesis of RUNT-domain transcription factor [11][12] . In addition, MMP8 rs11225394, MMP3 rs650108 and RS522616, as well as MMP14 rs2236302 signi cantly correlated with non-traumatic ONFH [13][14][15] . Furthermore, Clotting factor V, MTHFR and PAI-1 variants correlated with high coagulation or low brinolysis, which might promote intravascular coagulation or weaken thrombolysis, causing ischemic necrosis of the femoral head [16][17][18] .…”

Cyclic Polypeptide D7 Protects Bone Marrow Mesenchymal Cells and Promotes Chondrogenesis during Osteonecrosis of the Femoral Head via Growth Differentiation Factor 15-Mediated Redox Signaling

“…Osteonecrosis of the femoral head (ONFH) is a progressive disease that causes collapse of the joint cartilage and the femoral head, leading to substantial hip pain and loss of joint function [ 1 , 2 ]. Clinical application of glucocorticoids (GCs) is the leading cause of ONFH, also called steroid-induced ONFH (SONFH).…”

Therapeutic perspectives of exosomes in glucocorticoid-induced osteoarthrosis

“…ONFH is a chronic disease that seriously affects the life quality of patients. ONFH, which usually occurs in young patients, may cause the femoral head to collapse and even require the replacement of all hip joints, accompanied by systemic functional defects and serious defects (24)(25)(26). So far, a variety of surgical methods have been used for total hip replacement and autologous cell transplantation.…”