Association between Helicobacter pylori Infection and Colorectal Adenomatous Polyps

Abstract

Background. Helicobacter pylori infection is a common chronic infection worldwide. At the same time, the incidence of colorectal adenomatous polyps is also at high levels. In order to assess the relationship between Helicobacter pylori infection and the occurrence of colorectal adenomatous polyps, we observed 166 patients who had undergone an electronic colonoscopy and 13C urea breath test in the outpatient clinic. Method. A total of 166 (87 males and 79 females, aged 53.85±9.18 years) patients who had colonoscopy examination and 13C urea breath test were divided into a Helicobacter pylori-positive group (n=68) and Helicobacter pylori-negative group (n=98) by the 13C urea breath test. At the same time, total cholesterol, triglycerides, and fasting blood sugar were measured and the occurrence of hypertension was counted. Results. Patients with Helicobacter pylori infection had higher incidence of colorectal adenomatous polyps and multiple colorectal adenomatous polyps, higher levels of total cholesterol and fasting glucose, and more males (P<0.05, P<0.01). It was found that Helicobacter pylori infection (P<0.05, OR 2.383) was significantly associated with the risk of colorectal adenomatous polyps by binary logistic regression analysis. Conclusions. Patients with Helicobacter pylori infection had higher incidence of colorectal adenomatous polyps.

Association Between H. pylori Infection and Colorectal Polyps: A Meta-Analysis of Observational Studies

“…Characteristics of the included studies are shown in Table 1 . Overall, 17 studies, i.e., five case-control studies ( 13 , 14 , 17 , 25 , 27 ) and 12 cross-sectional studies ( 15 , 16 , 18 – 24 , 26 , 28 , 29 ), with 322,395 participants were analyzed in the meta-analysis. The crude prevalence rates of any colorectal polyps in H. pylori infection and un-infection groups were 23.9% (8153/34088) and 15.0% (43170/288307), respectively.…”

“…A total of 34,088 participants had H. pylori infection (10.6%). Outcomes of overall colorectal polyps were reported in five studies ( 14 , 20 , 22 , 25 , 28 ), AP in 15 studies ( 13 , 15 – 24 , 26 – 29 ), advanced AP in three studies ( 18 , 22 , 23 ), HP in three studies ( 22 , 27 , 28 ), and SSP in one study ( 27 ). Age, sex, social class, body mass index (BMI), smoking, alcohol drinking, and other potential confounding factors, such as parameters of lipids and glycemic metabolism, were adjusted to a varying degree when the associations between H. pylori infection, and colorectal polyps were reported.…”

Factors Associated with Colorectal Polyps in Middle-Aged and Elderly Populations

“…The present study showed that gastric and duodenal ulcers are independently associated with colorectal polyps. The mechanism of the association is not completely understood, but several studies have shown that colorectal polyps and colorectal cancer are associated with Helicobacter pylori ( H. Pylori ) infection [ 27 , 28 , 29 , 30 , 31 , 32 ]. Since H .…”

Kolorektal premalign polipler ile mide premalign lezyonları arasındaki ilişki

“…Boyutu büyük (>10 mm), villöz yapı veya yüksek dereceli displazi gibi histopatolojik bulguları olan polipler 'ileri adenomatöz polip' (İAP) olarak adlandırıldı.TARTIŞMAÇalışmamızda kolorektal poliplerin yeri, sayısı ve İAP ile premalign mide lezyonları (H. pylori, intestinal metaplazi, atrofi, displazi ve polip) arasında ilişki yoktu. H. pylori enfeksiyonu olan hastalarda kolorektal adenomatöz poliplerin daha sık olduğu gösterilmiştir(14). Brim ve ark.…”

“…TARTIŞMAÇalışmamızda kolorektal poliplerin yeri, sayısı ve İAP ile premalign mide lezyonları (H. pylori, intestinal metaplazi, atrofi, displazi ve polip) arasında ilişki yoktu. H. pylori enfeksiyonu olan hastalarda kolorektal adenomatöz poliplerin daha sık olduğu gösterilmiştir(14). Brim ve ark.…”