Factors Associated with Colorectal Polyps in Middle-Aged and Elderly Populations

Abstract

Colorectal polyps are the precursor lesions of most colorectal cancers. This study aimed to evaluate associations between bone mineral density (BMD), metabolic syndrome (MetS), and gastrointestinal diseases with colorectal polyps in middle-aged and elderly populations. A retrospective cross-sectional study was performed using data from the health examination database of a tertiary medical center in southern Taiwan in 2015. Subjects aged 50 years and older who had been assessed for metabolic factors and had undergone colonoscopy, upper gastrointestinal endoscopy, and dual energy X-ray absorptiometry scan (DEXA) were included. Factors associated with colorectal polyps were evaluated using univariate and multivariate logistic regression. In total, 1515 subjects were included, with mean age 60.1 years. Among them, 710 (46.9%) had colorectal polyps. Multivariate logistic regression analysis showed that high fasting glucose (OR = 1.08, p = 0.001), high triglycerides (OR = 1.02, p = 0.008), high total cholesterol (OR = 1.004, p = 0.009), reflux esophagitis (OR = 1.44, p = 0.002), duodenal polyps (OR = 1.75, p = 0.026), gastric ulcer (OR = 1.38, p = 0.024), duodenal ulcers (OR = 1.45, p = 0.028), osteopenia (OR = 1.48, p = 0.001), and MetS (OR = 1.46, p < 0.001) were independently associated with colorectal polyps. In conclusion, hyperglycemia, hypercholesterolemia, hypertriglyceridemia, MetS, duodenal polyps, gastric and duodenal ulcers, reflux esophagitis, and low BMD are independent risk factors associated with colorectal polyps in the middle-aged and elderly Taiwanese population.

Big data mining to screen hub molecular targets related to metabolic abnormalities, intestinal polyps and colorectal cancer

“…In other words, it may imply a higher risk of CRC for those in the MetS group. A recent study showed that, MetS is a independent risk factor associated with colorectal polyps in the middle-aged and elderly Taiwanese population [42]. Therefore, the relapse of intestinal polyps caused by MetS is most likely the reason for the number of older people in the MetS group.…”

Gastric Polyps Detected Incidentally during Gastroscopy and Follow-Up Results

“…Gastric fundus gland polyps are the main components of gastric polyps, most of which are manifestations of long-term proton pump inhibitor treatments [ 3 ]. Reporting the opposite of this situation, Loke et al reported that the incidence of gastric polyps in the groups of patients over 50 years of age with and without colorectal polyps was found to be statistically insignificant [ 31 ]. Therefore, some studies suggest that the etiology of positive relationships may be related to the decrease in the stomach acid barrier [ 3 ].…”

Association of egg consumption with colorectal polyp prevalence: findings from the Lanxi Pre-Colorectal Cancer Cohort (LP3C) in China

“…6 Besides, elevated serum total cholesterol was reported to be an independent risk factor for colorectal polyps in the Taiwanese population aged 50 years and older. 7 However, other essential nutrients, such as minerals and vitamins in eggs may exert protective effects. According to the analysis from 3 large prospective studies, higher dietary vitamin D intake could lower the risk of precursor lesions for CRC and higher calcium intake could reduce the risk of conventional adenomas.…”