Association between <i>Helicobacter pylori</i> and recurrent aphthous stomatitis in children and adolescents

Fritscher, Angélica Maria Genehr; Cherubini, Karen; Chies, José Artur Bogo; Dias, A. C. O.

doi:10.1111/j.0904-2512.2004.00074.x

Cited by 43 publications

(28 citation statements)

References 27 publications

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“…However, of the rosacea patients infected with H. pylori who did not eradicate 39 lichen planus 40 and aphthous stomatitis. 41,42 Recent studies suggest that rosacea is associated with the generation of reactive oxygen species (ROS) that are released by inflammatory cells such as neutrophils. Exaggerated production of ROS or inadequate antioxidant protection creates a condition known as oxidative stress, which is thought to play an important role in skin cancers, cutaneous aging and in many inflammatory skin diseases.…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori infection but not small intestinal bacterial overgrowth may play a pathogenic role in rosacea

Gravina¹,

Federico²,

Ruocco

et al. 2015

UEG Journal

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Background and aims: Recent studies suggest a potential relationship between rosacea and Helicobacter pylori (H. pylori) infection or small intestinal bacterial overgrowth (SIBO), but there is no firm evidence of an association between rosacea and H. pylori infection or SIBO. We performed a prospective study to assess the prevalence of H. pylori infection and/or SIBO in patients with rosacea and evaluated the effect of H. pylori or SIBO eradication on rosacea. Methods: We enrolled 90 patients with rosacea from January 2012 to January 2013 and a control group consisting of 90 patients referred to us because of mapping of nevi during the same period. We used the 13 C Urea Breath Test and H. pylori stool antigen (HpSA) test to assess H. pylori infection and the glucose breath test to assess SIBO. Patients infected by H. pylori were treated with clarithromycin-containing sequential therapy. Patients positive for SIBO were treated with rifaximin. Results: We found that 44/90 (48.9%) patients with rosacea and 24/90 (26.7%) control subjects were infected with H. pylori (p ¼ 0.003). Moreover, 9/90 (10%) patients with rosacea and 7/90 (7.8%) subjects in the control group had SIBO (p ¼ 0.6). Within 10 weeks from the end of antibiotic therapy, the skin lesions of rosacea disappeared or decreased markedly in 35/36 (97.2%) patients after eradication of H. pylori and in 3/8 (37.5%) patients who did not eradicate the infection (p < 0.0001). Rosacea skin lesions decreased markedly in 6/7 (85.7%) after eradication of SIBO whereas of the two patients who did not eradicate SIBO, one (50%) showed an improvement in rosacea (p ¼ 0.284). Conclusions: Prevalence of H. pylori infection was significantly higher in patients with rosacea than control group, whereas SIBO prevalence was comparable between the two groups. Eradication of H. pylori infection led to a significant improvement of skin symptoms in rosacea patients.

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Section: Discussionmentioning

confidence: 99%

Helicobacter pylori infection but not small intestinal bacterial overgrowth may play a pathogenic role in rosacea

Gravina¹,

Federico²,

Ruocco

et al. 2015

UEG Journal

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“…By this method, H. pylori has been detected more frequently in oral samples but results show a great variation as the published reviews point out (7,14,20). Recent studies using conventional PCR still report very variable results, with a detection rate ranging from 0% to 100% (1,5,8,9,11,(31)(32)(33). These discrepancies can be explained by differences in the study populations, oral sample collection methods and laboratory detection procedures.…”

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confidence: 99%

Absence of Helicobacter pylori in the oral cavity of 10 non‐dyspeptic subjects demonstrated by real‐time polymerase chain reaction

Martínez-Gomis¹,

Diouf²,

Lakhssassi³

et al. 2006

Oral Microbiology and Immunology

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Helicobacter pylori is a gram-negative, curved, microaerophilic organism that has been implicated in the aetiology of gastritis, in the process of gastric and duodenal ulcer formation, and in gastric cancer (15,17). Approximately 10% of individuals are affected by gastritis and/or gastric ulcer during their lifetime and over 50% of the world's population carries this infection (7). The prevalence of gastric H. pylori infection depends on age and varies strongly between developing and developed countries, and according to ethnicity, place of birth and socioeconomic factors among people living in the same country Background/aims: Helicobacter pylori plays a significant role in gastric disease. However, the presence of this bacterium in the oral cavity remains controversial. The aim of the present study was to detect and quantify H. pylori in 29 different sites of the oral cavity in non-dyspeptic subjects by means of real-time polymerase chain reactions (PCR). Methods: Ten subjects without gastric symptoms were studied. Samples from unstimulated saliva, three sites of the tongue, oral mucosa, and 12 sites of both supragingival and subgingival plaque were collected from each subject. DNA was extracted from the oral samples and analysed for the presence of H. pylori by real-time PCR (LightCycler Ò ) using JW23/22 primers which targeted the 16S rRNA gene. DNA from H. pylori DSM 4867 was used as a positive control. Relative quantification with external standards was performed by calculating the target to reference ratio. Results: Amplification efficiency for the LightCycler Ò 2.0 runs ranged from 1.8 to 2.4. Melting curve analysis identified all the positive control capillaries, which contained H. pylori reference DNA, as a single and narrow peak at a melting temperature between 84.5 and 84.9°C. All the negative control capillaries with no template control and the 29 oral samples from each subject showed either no melting peaks or broad melting peaks below 80°C, which were considered as primer dimers. Therefore, H. pylori was not detected from any of the 290 oral samples. Conclusion: Helicobacter pylori seems not to be permanently present in the oral cavity of a non-dyspeptic population.

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“…pylori infection which serves as a main cause of peptic ulcer and may lead to gastritis and cancer has also been considered in different oral lesions such as aphthous stomatitis and periodontitis. However no strong association was observed between the presnce of H. pylori in oral cavity and oral lesions in patients with recurrent aphthous stomatitis (Victoria et al, 2003;Fritscher et al, 2004), it was detected in the saliva and subgingival samples in a high percentage of patients with periodontitis (Gebara et al, 2004;Souto and Colombo, 2008).…”

Section: Discussionmentioning

confidence: 95%

Lack of Association Between Helicobacter pylori Infection and Oral Lichen Planus

Pourshahidi

Fakhri

Ebrahimi³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Oral lichen planus is a premalignant chronic inflammatory mucosal disorder with unknown etiology. It is a multifactorial disease and in addition to genetic background, infections, stress, drug reactions are suggested as risk factors. Helicobacter pylori which is involved in development of many gastrointestinal lesions may also be implicated in oral lichen planus induction. This is of clear importance for cancer prevention and the present study was performed to determine any association between H. pylori infection and oral lichen planus in southwestern Iran. Anti H. pylori IgG levels were determined in 41 patients and 82 sex-age matched controls. The results showed no association between H. pylori infection and oral lichen planus (51% in patients vs. 66% in control). or any of its clinical presentations.

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Association between Helicobacter pylori and recurrent aphthous stomatitis in children and adolescents

Abstract: There was no association between RAS lesions and infection of the oral cavity by H. pylori in children and adolescents (P = 0.254).

Cited by 43 publications

References 27 publications

Helicobacter pylori infection but not small intestinal bacterial overgrowth may play a pathogenic role in rosacea

Helicobacter pylori infection but not small intestinal bacterial overgrowth may play a pathogenic role in rosacea

Absence of Helicobacter pylori in the oral cavity of 10 non‐dyspeptic subjects demonstrated by real‐time polymerase chain reaction

Lack of Association Between Helicobacter pylori Infection and Oral Lichen Planus

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