Association between <i>Echinococcus granulosus</i> infection and cancer risk – a pilot study in Cyprus

Οικονομοπούλου, Κατερίνα; Yu, Herbert; Wang, Zhanwei; Vasiliou, Stella K; Brinc, Davor; Christofi, G; Theodorou, Marilena; Pavlou, Pavlos; Hadjisavvas, Andreas; Demetriou, Christiana A.; Kyriacou, Kyriacos; Diamandis, Eleftherios P.

doi:10.1515/cclm-2016-0125

Cited by 23 publications

(21 citation statements)

References 47 publications

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“…However, our findings were in disagreement with a previous retrospective study which investigated the relationship between prior echinococcus granulosus infection and cancer development, an indication of possible cancercausing risks of echinococcus granulosus infection [30]. In another retrospective study, it was shown that echinococcus infection may have a pro-cancerogenic effect through modulating the immune response.…”

Section: Discussioncontrasting

confidence: 99%

Co-existence of hepatocellular carcinoma and cystic echinococcosis

Ran

Yasen

Shao

et al. 2020

Infect Agents Cancer

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Purpose: Coexistence of hepatocellular carcinoma (HCC) and cystic echinococcus (CE) is extremely rare. Echinococcus granulosus may exhibit a protective effect against cancer. Herein, this study aimed to evaluate the possible effects of echinococcal infection on HCC patients. Methods: Three thousand three hundred hepatic CE patients and 815 HCC patients were retrospectively reviewed between January 2010 and December 2018 in Xinjiang, China, and these patients were 1:5 matched according to their sex, age and tumor TMN stage, and only 13 patients coexisted both CE and HCC. Preoperative ultrasonography (US), computed tomography (CT), liver magnetic resonance imaging (MRI) and dot immune-gold filtration assay (DIGFA) were used for preoperative identification and intraoperative specimens from liver resections were pathologically examined for further confirmation. Survival time was analyzed through Cox proportional hazard model analysis. Results: The co-existing incidence rate of two diseases was 0.39%. For these concurrent cases, HCC was all at the advanced stage and CE lesions were inactive. Median survival time for HCC patients was 6 month (1-17). However, it was 8 month (3-90) for the co-existing cases and was much longer than the median survival time of HCC patients (P< 0.05), which was closely associated with tumor size, location, TMN stage and hydatid size, location, classification. Four of the patients underwent surgical intervention and their median survival time was 17 month (3-68). Conclusions: Echinococcus granulosus may elicit a protective effect against the development and progression of HCC, while more basic and clinical researches are needed.

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Section: Discussioncontrasting

confidence: 99%

Co-existence of hepatocellular carcinoma and cystic echinococcosis

Ran

Yasen

Shao

et al. 2020

Infect Agents Cancer

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“…Faster growth of cysts in CE patients with AIDS suggests that immune suppression may play a role in CE progression (67,68). Conversely, the concept of an enhancing effect of CE on the occurrence of cancer in the population, because of a defect in immune surveillance linked to an Echinococcus-induced tolerance state, has been raised recently (69,70), although this hypothesis has not been rigorously evaluated. In areas where CE is endemic, the simultaneous occurrence of two frequent diseases cannot be ruled out, and preliminary assessment from hospital medical information systems of the occurrence of cancer in 2,350 patients with CE compared with patients without CE showed no difference (Bo Ran, First Affiliated Hospital of Xinjiang Medical University, personal communication).…”

Section: Clinical Featuresmentioning

confidence: 99%

Echinococcosis: Advances in the 21st Century

Wen¹,

Vuitton²,

et al. 2019

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SUMMARY Echinococcosis is a zoonosis caused by cestodes of the genus Echinococcus (family Taeniidae). This serious and near-cosmopolitan disease continues to be a significant public health issue, with western China being the area of highest endemicity for both the cystic (CE) and alveolar (AE) forms of echinococcosis. Considerable advances have been made in the 21st century on the genetics, genomics, and molecular epidemiology of the causative parasites, on diagnostic tools, and on treatment techniques and control strategies, including the development and deployment of vaccines. In terms of surgery, new procedures have superseded traditional techniques, and total cystectomy in CE, ex vivo resection with autotransplantation in AE, and percutaneous and perendoscopic procedures in both diseases have improved treatment efficacy and the quality of life of patients. In this review, we summarize recent progress on the biology, epidemiology, diagnosis, management, control, and prevention of CE and AE. Currently there is no alternative drug to albendazole to treat echinococcosis, and new compounds are required urgently. Recently acquired genomic and proteomic information can provide a platform for improving diagnosis and for finding new drug and vaccine targets, with direct impact in the future on the control of echinococcosis, which continues to be a global challenge.

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“…A significantly lower prevalence of cancer was reported in patients with hydatid disease in a large retrospective study in Turkey ( 7 ). In direct contrast, a pilot retrospective study carried out in Cyprus indicated that echinococcosis may increase cancer risk in patients ( 10 ). In the main, there is more evidence to support the concept that E .…”

Section: Introductionmentioning

confidence: 99%

Echinococcus granulosus: Cure for Cancer Revisited

Ranasinghe

McManus

2018

Front. Med.

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Whereas a number of parasites are well recognized risk factors for a number of different cancers in mammalian hosts, there is limited information on the ability of parasitic organisms to induce anticancer effects. There are conflicting reports that echinococcosis, caused by the canine tapeworm Echinococcus granulosus, can decrease or increase cancer risk. This review considers both indirect anticancer effects as the result of adaptive immunity generated against certain echinococcal antigens and the direct effect of molecules released by E. granulosus whose activity directly inhibits cancer cell migration and growth. In conclusion, E. granulosus probably secretes molecules that can be developed as anticancer therapeutics in future.

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Association between Echinococcus granulosus infection and cancer risk – a pilot study in Cyprus

Abstract: Our study suggests that infection by E. granulosus may increase cancer risk. If this observation can be confirmed independently, further investigation of the mechanisms underlying the association is warranted.

Cited by 23 publications

References 47 publications

Co-existence of hepatocellular carcinoma and cystic echinococcosis

Co-existence of hepatocellular carcinoma and cystic echinococcosis

Echinococcosis: Advances in the 21st Century

Echinococcus granulosus: Cure for Cancer Revisited

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