Association betweenAPOEpolymorphism and metabolic syndrome in Uyghur ethnic men

Abstract

ObjectivesThis study aimed to examine the association between apolipoprotein E (APOE) polymorphism and metabolic syndrome (MetS) among Uyghur ethnic men in Xinjiang, China.ParticipantsA total of 482 patients with MetS and 510 healthy sex-matched and age-matched controls were recruited from the Xinjiang Uyghur Autonomous Region of China. The participants were subjected to routine physical and blood biochemical tests, and APOE genotyping was performed.ResultsThe APOE ε3/3 was the predominant type, with a frequency of 71.8%, while ε2/2 was less common than ε4/4 in Uyghur males. The frequencies of the APOE2, E3 and E4 alleles in Uyghur males were 8.5%, 80.0% and 11.5%, respectively. However, the distribution of APOE genotypes was significantly different between the MetS and control groups (p<0.001). In the MetS group, the frequencies of the ε2 and ε4 alleles and the frequencies of the ε2/2, ε2/3 and ε2/4 genotypes were significantly lower than those of the control group. Those individuals without the ε2 and ε4 alleles had higher MetS prevalence than the other gene carriers, and the ORs of these individuals developing MetS were 1.5 and 1.27 compared to the gene carriers. Triglyceride, serum total cholesterol and low-density lipoprotein cholesterol levels were lower and serum high-density lipoprotein was higher in the ε2 carriers than the ε3 carriers, and the prevalence of MetS, central obesity, high blood pressure, hypercholesterolaemia and hypertriglyceridaemia was lower in the APOE2 group than in the APOE4 group. The risks of these individuals with ε4 allele carriers getting these changes were 1.327, 1.780, 1.888, 1.428 and 2.571 times greater than those of ε2 allele carriers.ConclusionsAPOE4 is associated with many individual components of MetS, whereas APOE2 was associated with a reduced risk of MetS at the univariate level in Uyghur ethnic men.

Effects of polymorphisms in APOB, APOE, HSD11β1, PLIN4, and ADIPOQ genes on lipid profile and anthropometric variables related to obesity in children and adolescents

“…Our work is in agreement with Sun et al (2016) who also found some increased variables, such as BMI and LDL-C, in ε3 allele carriers when compared to ε2 allele carriers in the non-metabolic syndrome group ( Sun et al , 2016 ). Some studies also have associated the ε4 allele with features related to obesity in different populations ( Tabatabaei-Malazy et al , 2012 ; Alharbi et al , 2017 ).…”

Low prevalence of lipid metabolism abnormalities in APOE ε2-genotype and male patients 60 years or older with schizophrenia

“…A study with elderly Brazilian women found that triglyceride values were higher in ε2 carriers than in ε4 carriers [34]. In contrast, no obvious relationship between APOE status and serum triglycerides was reported in a study with patients with metabolic syndrome [35], which is in line with our findings. Moreover, the lack of correlation between high density lipoprotein and the APOE genotype that we noted in this study is consistent with other results [36].…”

Integrative Analysis to Identify Common Genetic Markers of Metabolic Syndrome, Dementia, and Diabetes

“…Existence of the APOE ɛ4 allele has also been associated with increased risk for cerebral amyloid angiopathy and age-related cognitive decline during normal ageing. Conversely, numerous studies found an association between MetS and diabetes with APOE allele [ 24 – 28 ]. Association of APOE gene polymorphisms with diabetes, cardiovascular diseases, and dementia is well known.…”

“…Therefore, it is biologically plausible that individuals carrying abnormal APOE allele might influence an individual’s susceptibility to MetS, especially in terms of both triglyceride and cholesterol dysmetabolism, which are major complications of MetS. A recent genetic association in Chinese ethnicity showed a strong association between MetS components with APOE4, whereas an inverse association was observed with APOE2 [ 30 ]. Also, a recent meta-regression analysis of 30 studies involving 5,423 diabetes cases and 8,197 healthy unrelated controls demonstrated a modest association between APOE allele and diabetes (odds ratio: 1.18 [95% CI: 1.02–1.35]) [ 31 ].…”