Association between Hypertension and the Prevalence of Low Back Pain and Osteoarthritis in Koreans: A Cross-Sectional Study

Bae, Young-Hyeon; Shin, Joon‐Shik; Lee, Jinho; Kim, Me-riong; Park, Ki Byung; Cho, Jaeheung; Ha, In‐Hyuk

doi:10.1371/journal.pone.0138790

Cited by 60 publications

(60 citation statements)

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“…Our individual-level analyses of alcohol consumption suggested a small protective effect of alcohol consumption, as has occasionally been noted previously [43, 50], but this association was no longer present after adjustment for familial factors. Overall, co-twin control results for the association of smoking and alcohol consumption with chronic back pain are consistent with a recent report suggesting no protective effect of healthy lifestyle behaviors on the prevention of chronic back pain in men[16].…”

Section: Discussionsupporting

confidence: 79%

Modifiable risk factors for chronic back pain: insights using the co-twin control design

et al. 2017

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BACKGROUND: Inconsistent associations between modifiable risk factors and chronic back pain (CBP) may be due to the inability of traditional epidemiologic study designs to properly account for an array of potential genetic and environmental confounding factors. The co-twin control research design, comparing modifiable risk factors in twins discordant for CBP, offers a unique way to remove numerous confounding factors. PURPOSE: To examine the association of modifiable lifestyle and psychological factors with lifetime CBP. STUDY DESIGN/SETTING: Cross-sectional co-twin control study in a nationwide sample of male twin members of the Vietnam Era Twin Registry. PATIENT SAMPLE: 7,108 participants including 1,308 monozygotic (MZ) pairs and 793 dizygotic pairs. OUTCOME MEASURE: Self-reported lifetime history of CBP. METHODS: Lifestyle factors included body mass index (BMI), smoking history, alcohol consumption, habitual physical activity, and typical sleep duration. Psychological factors included depression (Patient Health Questionnaire-9 [PHQ9]) and post-traumatic stress disorder (PTSD) symptoms (PTSD Checklist [PCL]). Covariates included age, race, education, and income. Odds ratios (ORs) and 95% confidence intervals (CI) were estimated for the association of risk factors with lifetime CBP when considering twins as individuals, and a within-pair co-twin control analysis that accounted for familial and genetic factors. Funding was through VA grant 5IK2RX001515; there were no study-specific conflicts of interest. RESULTS: The mean age of respondents was 62 years and the prevalence of lifetime CBP was 28%. All lifestyle factors were associated with CBP in the individual level analysis. However none of these persisted in the within-pair analyses, except for severe obesity (BMI≥35.0) which was associated with lifetime CBP in both individual-level (OR = 1.6, 95% CI 1.3–1.9) and within-pair analyses (MZ analysis: OR = 3.7, 95% CI 1.2–11.4). PTSD and depression symptoms were strongly associated with lifetime CBP in both the individual-level (moderate/severe depression: OR = 4.2, 95% CI 3.6–4.9 and severe PTSD: OR = 4.8, 95% CI 4.0–5.7) and within-pair (MZ) analyses (moderate/severe depression: OR = 4.6, 95% CI 2.4–8.7 and severe PTSD: OR = 3.2, 95% CI 1.6–6.5). CONCLUSIONS: Many associations between modifiable lifestyle risk factors and chronic back pain are due to confounding by familial and genetic factors. Severe obesity, depression, and PTSD should be considered in the development of intervention strategies to reduce the prevalence of chronic back pain.

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Section: Discussionsupporting

confidence: 79%

Modifiable risk factors for chronic back pain: insights using the co-twin control design

et al. 2017

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“…Furthermore, inverse correlation was reported between smoking and knee OA [24,25]. Bae et al showed that HTN was also associated with OA using KNHANES 2007–2009 data [26]. However, the findings of these earlier studies using KNHANES 2007–2009 data were not consistent with those of the current study.…”

Section: Discussioncontrasting

confidence: 78%

The Association between Osteoarthritis and Occupational Clusters in the Korean Population: A Nationwide Study

et al. 2017

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Osteoarthritis (OA) is a considerable health problem worldwide. It is known to be associated with certain occupational risk factors. We examined the prevalence rate of OA by occupational cluster. Data were collected from the Korea National Health and Nutrition Examination Surveys (2010–2013). The total number of unweighted sample size was 9,905 participants: 4,460 men and 5,445 women, and OA prevalence was 5.3% and 18.4% respectively. OA patients were defined as participants with knee/hip joint pain and radiographic change of knee/hip joint. Occupational type was classified as either white, pink, blue, or green collar based on the occupational characteristics following physical demand: white for manager and professionals; pink for clerks and service/sales workers; blue for craft/trade workers, machine operators and assemblers, and elementary manual workers; and green for agricultural/fishery workers. We calculated the odds ratios (ORs) and 95% confidence intervals (95% CI) for the odds of a participant’s having OA according to the occupational cluster, with gender stratification. The multiple logistic regression model showed that, compared to the white collar group, the ORs of the pink, blue, and green collar workers were 1.23 (95% CI 0.64–2.36), 1.85 (95% CI 1.18–2.88), and 2.91 (95% CI 1.86–4.54), respectively, in males, and 2.53 (95% CI 1.71–3.73), 2.86 (95% CI 1.94–4.21), and 3.90 (95% CI 2.60–5.83), respectively in females. The prevalence rate of OA was associated with the occupational cluster, in order from highest to lowest: green, blue, pink, and white collar.

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“…В свою очередь изменения в СХК зависят от сосу-дистого трофического потенциала, на который не-гативно влияет сосудистое ремоделирование [7]. Учитывая тесную взаимосвязь ОА с кардиоваску-лярными заболеваниями, было высказано пред-положение о том, что артериальная гипертония, атеросклероз и дислипидемия, реализующиеся через системное сосудистое ремоделирование, определяют тяжесть клинических симптомов, ско-рость прогрессирования и являются факторами риска развития ОА [8].…”

Section: âведениеunclassified

The Role of Vascular Remodeling in the Formation of Structural Phenotypes of Osteoarthritis

Кабалык¹,

Невзорова²

2018

Kuban. nauсh. med. vestnik

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Федеральное государственное учреждение высшего образования «Тихоокеанский государственный медицинский университет» Министерства здравоохранения Российской Федерации, пр-т Острякова, д. 2, г. Владивосток, Россия, 690002ABSTRACT Aim. Evaluation of the role of vascular remodeling in the formation of structural phenotypes of osteoarthritis (OA). Materials and methods. 62 patients with OA aged 65,9±8,8 years and 18 volunteers without clinical and roentgenologic signs of OA aged 60,7±7,9 years were examined. All patients underwent magnetic resonance imaging of knee joints. To analyze the structural changes in the tissues of the knee joint, the WORMS protocol was used for magnetic resonance imaging. The thickness of the vascular wall, the external diameter, the vascular index (VI) were measured -the ratio of the diameter of the lumen of the vessel to the thickness of the popliteal artery (PA) wall, the branch of the upper lateral artery (LA), the medial artery of the knee (MA).Results. The analysis of the parameters of the arteries of the knee joint showed that with a subchondral OA phenotype, the thickness of the PA wall is statistically significantly larger than the cartilage phenotype, and the vascular index of the PA is significantly higher in the group of the cartilaginous phenotype. The upper LA wall was significantly thicker in the subchondral OA phenotype. VI of the upper LA was significantly lower in patients with a subchondral phenotype compared

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Association between Hypertension and the Prevalence of Low Back Pain and Osteoarthritis in Koreans: A Cross-Sectional Study

Cited by 60 publications

References 40 publications

Modifiable risk factors for chronic back pain: insights using the co-twin control design

Modifiable risk factors for chronic back pain: insights using the co-twin control design

The Association between Osteoarthritis and Occupational Clusters in the Korean Population: A Nationwide Study

The Role of Vascular Remodeling in the Formation of Structural Phenotypes of Osteoarthritis

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