Association between hypertension and coffee drinking based on CYP1A2 rs762551 single nucleotide polymorphism in Taiwanese

Hou, Chien-Chou; Tantoh, Disline Manli; Lin, Chuan-Chao; Chen, Pei-Hsin; Yang, Hao-Jan; Liaw, Yung‐Po

doi:10.1186/s12986-021-00605-9

Cited by 7 publications

(4 citation statements)

References 44 publications

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“…A study of a Chinese population, showed that Individuals with CYP1A2 rs762551 C was associated with a lower risk of stroke than that of allele A 36 . In individuals with the CYP1A2 rs762551 AC + CC genotype, coffee consumption was associated with lower odds of hypertension 37 . Since hypertension is CYP1A2 variants risk factor for stroke, the study suggests that CYP1A2 variants may be indirectly associated with the development of stroke.…”

Section: Discussionmentioning

confidence: 92%

Association between urinary caffeine and caffeine metabolites and stroke in American adults: a cross-sectional study from the NHANES, 2009–2014

Fan¹,

Yuan²,

Zhang³

et al. 2023

Sci Rep

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This study investigates the potential correlation between urinary caffeine levels and the occurrence of stroke, a serious cerebrovascular disease that can lead to disability or death. The data used in this study was obtained from the National Health and Nutrition Examination Survey conducted between 2009 and 2014. The study analyzed a total of 5,339 individuals, divided into a control group (n = 5,135) and a stroke group (n = 162). The researchers utilized multiple logistic regression and smoothed curve fitting to examine the relationship between urinary caffeine and caffeine metabolites and the incidence of stroke. The study found that higher urinary caffeine levels were associated with a lower risk of stroke in Mexican American participants (odds ratio [OR] = 0.886, 95% confidence interval [CI]: (0.791, 0.993), P = 0.037). After adjusting for certain participant characteristics, it was also found that higher urinary paraxanthine levels were associated with a lower risk of stroke incidence (OR = 0.991, 95% CI (0.984, 0.999), P = 0.027). Meanwhile, the highest urinary paraxanthine levels group had 43.7% fewer strokes than the lowest level group (OR = 0.563, 95% CI (0.341, 0.929), P = 0.025). In this study, we showed a negative link between urine paraxanthine levels and the risk of stroke. Meanwhile, urinary caffeine levels were negatively associated with the incidence of stroke in Mexican Americans, but no correlation in other populations. Our findings may have predictive and diagnostic implications in clinical practice. Further extensive prospective investigations are still needed to validate our conclusions.

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Section: Discussionmentioning

confidence: 92%

Association between urinary caffeine and caffeine metabolites and stroke in American adults: a cross-sectional study from the NHANES, 2009–2014

Fan¹,

Yuan²,

Zhang³

et al. 2023

Sci Rep

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“…One Taiwanese study conducted by Hou Chien-Chou, et al 2021, where 19,133 individuals were genotyped in which those with the same gene variant CYP1A2 (rs762551), the subject variant showed a substantial association with coffee drinking. [9]. According to an Italian study, C allele variant of rs762551 demonstrated higher vulnerability to hypertension compared to A allele in Italian population[10].…”

Section: Discussionmentioning

confidence: 99%

Genetic Association ofCYP1A2Gene Variant (rs762551) with Caffeine Induced-Hypertension Susceptibility and Cytochrome P450 1A2 Protein Analyses

Amjad,

Saif,

Hussain

2023

Preprint

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High blood pressure is one of the most common illnesses affecting the Pakistani population due to, but not limited to, dietary habits, sedentary lifestyle and socio-economic aspects which have devastating effects on human health and general well-being. Caffeine is metabolized by CYP1A2 which results in lowered blood pressure while its retention in case of low metabolism may lead to hypertension. This phenomenon occurs because caffeine and its metabolites block A1 receptors in the kidney lowering the function of adenosine in blood pressure regulation. Current research aimed to demonstrate the genetic association ofCYP1A2gene variant 15:74749576C>A (C allele lowering CYP1A2 activity) within caffeine induced hypertensive individuals of Pakistani origin using ARMS-PCR. This pilot scale study revealed that overall, 8%, 56% and 36% sampled population (n=50) is homozygous wild-type (C/C), heterozygous (C/A) and homozygous mutant (A/A) respectively. Similarly, alternative allele frequency is 0.28 and 0.48 in cases and controls. Chi-square (χ2) association test using PLINK data analysis toolset was applied which showed significant results of χ2(2,N= 50) = 4.244,p= 0.039. Hardy Weinberg Equilibrium analysis was also applied which establishes that sampled population is obeying the principle withp-valueof 0.241. Moreover, odds-ratio depicts that the mutant allele is 0.42 times less prevalent in cases vs. controls. A few bioinformatics tools were employed e.g., ProtParam, PsiPred, PDB-RCSB, Motif finder, CTU-TMHMM-2.0, ScanProsite, GPS PAIL2.0, PRmePRed, NetOGlyc4.0, NetPhos3, SIFT analysis and STRING database in order to predict physicochemical properties, secondary structure, 3-dimensional structure, conserved motifs, transmembrane structure, post-translational modifications, protein variants impact on its function and protein-protein interactions respectively. The current endeavor attempted to provide the genetic architecture of the aforementioned variant in this case-control study in Pakistani individuals, which can pave paths of preventive medicine initiatives through genetic counsel of the masses.

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“…The acute consumption of caffeine or coffee may provoke a rise in systolic blood pressure (SBP), diastolic blood pressure (DBP) and catecholamine release (Eumann Mesas et al, 2011). However, these physiological effects may differ with chronic caffeine consumption, and some studies have shown that habitual coffee consumption impacts blood pressure (BP) (Renda et al, 2012), whilst others have found no difference (Hou et al, 2021). Similarly, a systematic review and meta‐analysis exploring the association between habitual coffee consumption and type 2 diabetes incidence suggested a 6% decreased risk of type 2 diabetes for each cup‐per‐day increase in coffee consumption (Carlström & Larsson, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…Besides the potential differences between acute and habitual caffeine and/or coffee consumption, there is heterogeneity in reported results (Carlström & Larsson, 2018; Hou et al, 2021; Renda et al, 2012). In part, this may be due to inter‐individual differences, more specifically single‐nucleotide polymorphisms (SNPs) affecting caffeine metabolism (Yang et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

The impact of genetic variability on the relationship between caffeine and cardiometabolic outcomes: A systematic review

et al. 2023

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The relationship between caffeine consumption and cardiometabolic health has been reported, however with heterogenous results. Discrepancies in study results may be due to inter‐individual variability between study participants. This systematic review aimed to identify the impact of genetics on the relationship between caffeine consumption and cardiometabolic outcomes. Electronic databases (PubMed and EMBASE) were searched for studies published until July 2021. Selected studies were of both intervention and observational design and included (1) analysis of at least one of the selected cardiometabolic outcome (type 2 diabetes, glucose/insulin levels, cardiovascular disease [CVD], blood pressure [BP] or hypertension, and blood lipid and catecholamine levels), (2) adults aged 18–65 years, and (3) genetic analysis of individuals consuming caffeine. Seventeen studies were included: four randomised controlled trials and an interventional and quasi‐experimental study, six population‐based prospective cohort studies, three cross‐sectional studies, and three case–control studies. CYP1A2 rs762551 and ADORA rs5751876 were associated with glucose response when caffeine was consumed with carbohydrates. CYP1A2 rs762551 moderated the association between coffee intake and hypertension. Moreover, ADORA2A rs5751876 and the ADRA2B I variants moderated the associations between caffeine and BP. Studies that investigated the effects of genetic variations on CVD and caffeine consumption reported equivocal findings (CYP1A2) or warrant replication (COMT, ADORA and TRIB1). Elucidating the extent to which these genes moderate the association between caffeine and cardiometabolic outcomes will enable caffeine consumption advice to be tailored to specific individuals to optimise health.

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Association between hypertension and coffee drinking based on CYP1A2 rs762551 single nucleotide polymorphism in Taiwanese

Cited by 7 publications

References 44 publications

Association between urinary caffeine and caffeine metabolites and stroke in American adults: a cross-sectional study from the NHANES, 2009–2014

Association between urinary caffeine and caffeine metabolites and stroke in American adults: a cross-sectional study from the NHANES, 2009–2014

Genetic Association ofCYP1A2Gene Variant (rs762551) with Caffeine Induced-Hypertension Susceptibility and Cytochrome P450 1A2 Protein Analyses

The impact of genetic variability on the relationship between caffeine and cardiometabolic outcomes: A systematic review

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