Association between human papillomavirus 16 E6 variants and human leukocyte antigen class I polymorphism in cervical cancer of Swedish women

Zehbe, Ingeborg; Mytilineos, Joannis; Wikström, Ingrid; Henriksen, Rudi; Edler, Lutz; Tommasino, Massimo

doi:10.1016/s0198-8859(03)00033-8

Cited by 77 publications

(70 citation statements)

References 13 publications

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“…In addition, B*44 was found to have a nominally negative association with SCC (P = 0.005, OR = 0). This observation on Chinese women is in contrast to studies on Swedish (Zehbe et al, 2003) and Netherlandish (Bontkes et al, 1998) women, where B*44 alleles were found to associate with an increased risk for cervical cancer. This different host genetic background may be part of the reasons accounting for the differences in risk association observed for Chinese and European women.…”

Section: Discussioncontrasting

confidence: 99%

HLA-A, HLA-B, HLA-DRB1 Polymorphisms and Risk of Cervical Squamous Epithelial Cell Carcinoma: A Population Study in China

Xiao¹,

Liu²,

Li³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Section: Discussioncontrasting

confidence: 99%

HLA-A, HLA-B, HLA-DRB1 Polymorphisms and Risk of Cervical Squamous Epithelial Cell Carcinoma: A Population Study in China

Xiao¹,

Liu²,

Li³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…As the target of humoral and cellular immune responses, the amino acid changes of HPV 16 E6 may have effects (2,13,39). D25E and L83V are associated with the elevated risk of cervical carcinomas and vary geographically due to genetic differences between populations (1,3,18,22,25,27,54,55). The D25E variant distributes mainly in Asian populations rather than in Russia (0%) (6,28,31,52).…”

Section: Discussionmentioning

confidence: 99%

Human Papillomavirus Type 16 Variant Analysis of E6, E7, and L1 Genes and Long Control Region in Identification of Cervical Carcinomas in Patients in Northeast China

et al. 2011

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Human papillomavirus type 16 (HPV 16) is the primary etiology of cervical cancer, which is the second most common type of cancer in women worldwide (29). HPV 16 variants, which vary by Յ2% from HPV 16 prototype nucleotide sequences, have been identified as the following six phylogenetic branches: European (E), Asian (As), Asian-American (AA), African-1 (Af-1), African-2 (Af-2), and northern American (NA) variants (18,52). Several researchers had reported correlations between specific HPV 16 variants and persistent viral infection, followed by the development of malignant lesions (3,4,16,37,43,49,50). Non-European variants were found to be associated with an excess risk of cervical cancer (37). These variants had been found to show different geographic distributions, while some sequence variations had oncogenic potentials. In HPV 16 variants, the L83V mutation in E6 in the Swedish and Italian populations and D25E in E6 in the Japanese population were reported to be associated with the

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“…However, the reported associations between HLA haplotypes and HPV-16 molecular variants are still conflicting. 18,19,33,34 The increased risk of HSIL associated with non-European variants could also be due to differences in the biological behavior of these genotypes. This has been addressed in vitro by studying the nucleotide variability in the LCR overlapping cellular transcription factors binding sites.…”

Section: Discussionmentioning

confidence: 99%

High grade cervical lesions are caused preferentially by non‐European variants of HPVs 16 and 18

Sichero

Ferreira²,

Trottier

et al. 2007

Intl Journal of Cancer

194

134

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The intratypic variability of HPVs 16 and 18 has been extensively studied and has been used as an important tool in epidemiological studies of viral transmission, persistence and progression to clinically relevant cervical lesions. Infections by non-European variants of HPVs 16 and 18 are associated with an increased risk for the development of high grade squamous intraepithelial lesions (HSIL). Our aim was to correlate the intratypic molecular variability of both HPV types and risk of persistent infection and lesion outcome in a cohort study conducted in Brazil. We characterized molecular variants of HPV types 16 and 18 by sequencing a fragment of the LCR, and of the E6 and L1 genes, for HPV-16 variants only. For both types, European variants composed the most prevalent and diverse group. Persistent infections with HPV-18 were associated with continuous detection of European variants. However, risk for simultaneous detection of HSIL and HPV DNA was higher in women harboring non-European variants of HPV-16. The same trend was observed with HSIL detected during follow-up. Our study confirms the association between non-European variants and risk of cervical neoplasia, and highlights the importance of their geographic distribution for cervical cancer risk assessment. ' 2007 Wiley-Liss, Inc.Key words: human papillomavirus; molecular variants; oncogenic potential; cohort study; cervical neoplasia More than 120 different human papillomavirus (HPV) genotypes associated with infections in humans have been described, of which approximately 40 infect the anogenital area. Nearly 20 of these are classified as high-risk HPV types (HR-HPV) due to their association with cancer. In particular, HPVs 16 and 18 are the most common high-risk types in cancer biopsies, worldwide. 1 Their oncogenic potential has been demonstrated both in vitro and in vivo. 2 Nevertheless, only a minority of women infected with HPVs 16 and 18 develop neoplastic lesions. 3,4 Intratypic molecular variants of HPVs are characterized by differences in nucleotide sequence from the prototypic L1 gene of less than 2%. 5 Recently, full genome analysis of HPV-16 isolates revealed that 4% of the sequence is variable. 6 Moreover, these authors described a 9.9% amino acid variability within the eight HPV genes of the different HPV-16 molecular variants studied. The nucleotide variability of HPVs 16 and 18 has been extensively studied, and several molecular variants have been described on the basis of their geographical distribution. 7-9 Studies conducted in multiethnic populations have shown the association between Asian-American or other non-European variants of HPVs 16 and 18 and increased risk of persistent infection and development of cervical lesion. 4,10-13 Specific variants of HPVs 16 and 18 seem to be associated also with certain histopathological features of cervical neoplastic lesions. 10,14,15 In one study, Asian-American variants of both HPVs 16 and 18 were associated with squamous cell carcinomas and adenocarcinomas, while European variants were assoc...

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Association between human papillomavirus 16 E6 variants and human leukocyte antigen class I polymorphism in cervical cancer of Swedish women

Cited by 77 publications

References 13 publications

HLA-A, HLA-B, HLA-DRB1 Polymorphisms and Risk of Cervical Squamous Epithelial Cell Carcinoma: A Population Study in China

HLA-A, HLA-B, HLA-DRB1 Polymorphisms and Risk of Cervical Squamous Epithelial Cell Carcinoma: A Population Study in China

Human Papillomavirus Type 16 Variant Analysis of E6, E7, and L1 Genes and Long Control Region in Identification of Cervical Carcinomas in Patients in Northeast China

High grade cervical lesions are caused preferentially by non‐European variants of HPVs 16 and 18

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