Association between holoprosencephaly and exposure to topical retinoids: results of the EUROCAT survey

Wals, Philippe De; Bloch, D. A.; Calabrò, Anna Rita; Calzolari, Elisa; Cornel, Martina C.; Johnson, Zachary R.; Ligutić, Ivo; Nc, Nevin; Pexieder, Tomáš; Stoll, Claude; Tenconi, Rossana; Tilmont, P

doi:10.1111/j.1365-3016.1991.tb00730.x

Cited by 30 publications

(19 citation statements)

References 10 publications

(2 reference statements)

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“…Three observational cohort studies and one patient registry met the inclusion criteria, including a total of 590 infants born to 654 retinoid‐exposed pregnancies and 1278 infants born to 1375 control (unexposed) pregnancies, respectively. The case–control study by De Wals et al . was excluded as this study assessed only holoprosencephaly, and not all major congenital malformations, as its outcome.…”

Section: Resultsmentioning

confidence: 99%

“…However, the concern that topical retinoids may be associated with major congenital malformations was initially raised by three reports, which the U.S. Food and Drug Administration (FDA) received between 1986 and 1989, regarding infants with holoprosencephaly whose mothers had been exposed to topical retinoids . Based on these findings, a case–control study using the EUROCAT registry failed to confirm an association . In the following years, six cases of infants with various major congenital malformations were reported where the mothers had been exposed to topical retinoids during their pregnancy.…”

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confidence: 99%

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Pregnancy outcomes following first-trimester exposure to topical retinoids: a systematic review and meta-analysis

et al. 2015

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Evaluation of human data regarding the outcomes of topical-retinoid-exposed pregnancies is important in terms of counselling pregnant women with inadvertent exposure. The objective of this study was thus to determine whether exposure to topical retinoids leads to an increase in the risk of adverse pregnancy outcomes. We carried out a search using the Medline, Embase, Web of Science and Cochrane Central Register of Controlled Trials databases from inception to 4 December 2014. The selection, review and quality assessment of the studies were carried out by two independent reviewers according to predetermined inclusion criteria. Odds ratios (ORs) were calculated by the random effects method. This meta-analysis, including a total of 654 pregnant women who were exposed to topical retinoids, and 1375 unexposed control pregnant women, did not detect significant increases in rates of major congenital malformations [OR 1·22, 95% confidence interval (CI) 0·65-2·29], spontaneous abortions (OR 1·02, 95% CI 0·64-1·63), stillbirth (OR 2·06, 95% CI 0·43-9·86), elective termination of pregnancy (OR 1·89, 95% CI 0·52-6·80), low birthweight (OR 1·01, 95% CI, 0·31-3·27) or prematurity (OR 0·69, 95% CI 0·39-1·23). No significant heterogeneity was detected among the studies for the evaluated outcomes. The present meta-analysis ruled out a major increase in the rates of major congenital malformations, spontaneous abortions, low birthweight and prematurity. This result may be used primarily in reassuring women who were inadvertently exposed to topical retinoids during their pregnancy. However, the statistical power is not adequate to justify the use of topical retinoids during pregnancy.

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

Pregnancy outcomes following first-trimester exposure to topical retinoids: a systematic review and meta-analysis

et al. 2015

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“…2 Recognized environmental factors include insulin dependent maternal diabetes and alcoholism. However drugs like retinoic acid 3 and methotrexate 4 have also been implicated.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis of holoprosencephaly in the first trimester

Paliwal

Singh

Gholkar

et al. 2013

Int J Reprod Contracept Obstet Gynecol

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“…Other causes include diabetes mellitus, ethanol, retinoids, cytomegalovirus and accidental ingestion of the Veratrum californicum plant 89. The prenatal ultrasonographic diagnosis of ethmocephaly is based on an absent midline echo, single dilated ventricle and fused thalami 10.…”

Section: Discussionmentioning

confidence: 99%

Ethmocephaly with amniotic band syndrome

Das

Gayen

Bandyopadhyay

et al. 2012

Middle East Afr J Ophthalmol

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Ethmocephaly is the rarest form of holoprosencephaly, which occurs due to an incomplete cleavage of the forebrain. Clinically, the disease presents with a proboscis, hypotelorism, microphthalmos and malformed ears. Amniotic band syndrome is another rare congenital malformation with ring-like constriction bands in the limbs, head, face or trunk. We present a case of ethmocephaly with amniotic band syndrome, which is likely the first of its kind, published in the literature.

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Association between holoprosencephaly and exposure to topical retinoids: results of the EUROCAT survey

Cited by 30 publications

References 10 publications

Pregnancy outcomes following first-trimester exposure to topical retinoids: a systematic review and meta-analysis

Pregnancy outcomes following first-trimester exposure to topical retinoids: a systematic review and meta-analysis

Diagnosis of holoprosencephaly in the first trimester

Ethmocephaly with amniotic band syndrome

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