Association between HLA gene polymorphism and cutaneous adverse reactions caused by antiepileptic drugs

Abstract

The association between cutaneous adverse drug reactions (cADRs) caused by antiepileptic drugs (AEDs) and human leukocyte antigen-A (HLA-A) and HLA-B genes in Chinese Han population in Shanghai was investigated. Through the case-control study, 30 child patients with AED-induced cADRs (cADRs group), 60 AED-tolerant child patients (AED-tolerant group) and 60 normal children not taking AEDs (normal group) were collected. The HLA-B*15:02 and HLA-A*31:01 genotypes were detected using the polymerase chain reaction-sequence-specific oligonucleotide (PCR-SSO) probe method, and the correlation of HLA-B*15:02 and HLA-A*31:01 genes with the incidence of cADRs was analyzed. The positive rate of HLA-B*15:02 gene was 83.33% in the cADRs group, which was significantly increased compared with that in the AED-tolerant and normal groups (P<0.01). The positive rate of HLA-A*31:01 gene was 63.33% in the cADRs group, which was obviously increased compared with that in the AED-tolerant and normal groups (P<0.01). There were no significant differences in HLA-B*15:02 and HLA-A*31:01 genotypes between the AED-tolerant and normal groups (P>0.05). The results showed that HLA-B*15:02 and HLA-A*31:01 are significantly associated with cADRs in a Chinese Han population in Shanghai, suggesting that HLA-B*15:02 and HLA-A*31:01 genotypes should be detected in the application of AEDs.

HLA alleles and antiseizure medication‐induced cutaneous reactions in Brazil: A case‐control study

“…Therefore, it is not possible to state the difference in carrier frequency between the control population and CAR+ patients is due to sensitivity to these drugs. Although previous studies with smaller samples of tolerant and sensitive individuals in other populations found an association between the HLA‐A*31:01 allele and ASM‐induced CAR, the absence in our study, despite the sample size, of any differences when tolerant and sensitive patients were compared suggests that other variables may play a role in this difference 26–30 . Hence, future studies should investigate whether another variable can explain the strong difference between sensitive patients and control subjects and the absence of any difference between sensitive and tolerant patients.…”

“…Although previous studies with smaller samples of tolerant and sensitive individuals in other populations found an association between the HLA-A*31:01 allele and ASM-induced CAR, the absence in our study, despite the sample size, of any differences when tolerant and sensitive patients were compared suggests that other variables may play a role in this difference. [26][27][28][29][30] Hence, future studies should investigate whether another variable can explain the strong difference between sensitive patients and control subjects and the absence of any difference between sensitive and tolerant patients. We do not have enough evidence to indicate screening for this allele to prevent CAR among Brazilian patients even though it has a high prevalence in our population (9%).…”

Exfoliative dermatitis; new safety signal detection regarding Meropenem in VigiBase™: A study based on WHO database

“…Several studies that discussed and researched genetic susceptibility to SCARs showed higher susceptibility in Thai and Chinese populations due to specific Human Leukocyte Antigens (HLAs), [45][46][47][48][49] and that might explain why Thailand and China ranked first and second in the number of reports.…”