Association between HLA-G 3′UTR 14-bp polymorphism and HIV vertical transmission in Brazilian children

Abstract

Our findings support the possible role for the HLA-G 14-bp deletion/insertion polymorphism in the HIV vertical transmission in Brazilian children. The presence of the D allele and D/D genotype is associated with a protective effect toward HIV perinatal infection.

Association of HLA-G alleles and 3′ UTR 14 bp haplotypes with recurrent miscarriage in Brazilian couples

“…Therefore, determined haplotypic combinations of HLA-G alleles and presence or absence of the 14 bp segment could predispose women to RM. These findings also may open new doors in the understanding of the association of HLA-G alleles and 3=UTR 14 bp haplotypes with several disorders, such as susceptibility to virus infection or tumors progression, as evidence shows that 14 bp polymorphism at 3= UTR of could be a genetic risk factor for susceptibility to HTLV-1, human CMV, vertical transmission of HIV, and the development of cervical cancer after human papillomavirus infection [61][62][63][64].…”

Analysis of the plasma soluble human leukocyte antigen–G and interleukin-10 levels in childhood atopic asthma

“…Studies indicated that the polymorphism was associated with HLA-G mRNA stability and isoform alternative splicing pattern and influences protein expression level of HLA-G [14 -16]. The significance of this polymorphism association with many disorders, such as human cytomegalovirus infection, human immunodeficiency virus (HIV) vertical transmission, systemic lupus erythematosus, and idiopathic dilated cardiomyopathy have also been addressed [17][18][19][20].…”

Maternal human leukocyte antigen-G (HLA-G) genetic variants associate with in utero mother-to-child transmission of HIV-1 in Black South Africans

“…In the context MTCT of HIV-1, several reports have associated the 14-bp indel with the risk of MTCT (Segat et al, 2014, Sanches et al, 2013, Segat and Crovella, 2012, Segat et al, 2009, Fabris et al, 2009, Aikhionbare et al, 2006); but only one has associated HLA-G alleles with MTCT (Luo et al, 2013). However, some of these reports have been conflicting, for example: in Zambian infants, the Ins was associated with protection from IU and IP HIV-1 infection (Segat et al, 2014); yet in Brazilian children, the Del allele and Del/Del genotype associated with a protective effect from vertical transmission (Fabris et al, 2009).…”