Association between histocompatibility type and the ability to make anti‐Rh antibodies

Brain, Peter; Hammond, M. G.

doi:10.1002/eji.1830040313

Cited by 14 publications

(11 citation statements)

References 5 publications

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“…DR7 has previously been associated with nonresponsiveness to hepatitis vaccine (Walker et al 1981) and with failure to make white cell antibodies in multitransfused thalassemia major patients (Pollack et al 1982). Other studies have variably reported HLA associated responses to red cell immunization or lack of such responses (Brain & Hammond 1984, Raum et al 1984, Darke 1977.…”

Section: Discussionmentioning

confidence: 99%

Alloantibody responses in multiply transfused sickle cell patients

et al. 1987

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Fifty-six adult and 15 pediatric black patients with sickle cell disease were studied to determine their antibody responses to repeated transfusions of red cells. Red cell antibodies were determined restrospectively; anti-lymphocyte antibodies (class I and 11) were determined on the single, most recently drawn blood sample. All adults were HLA-A, B, C, DR and DQ typed. Ten percent of the individuals with less than SO transfusions, but greater than 50% with 100 transfusions or more, had red cell antibodies. The percentage of patients producing anti-red cell antibodies increased consistently with the number of transfusions (p = 0.0062). Women were more likely to become sensitized to red cell antigens than men (p = 0.008), and nulliparous women more likely than multiparous women. Children were also sensitized to red cell antigens (20%). and to a high degree to lymphocyte antigens (73%). No HLA association was found with increased propensity to red cell sensitization. A weak association of HLA DRS and DR7 with failure to become sensitized to lymphocyte alloantigens was observed, but did not reach statistical significance. Our results suggest that. while genetic factors influencing transfusion response almost certainly exist, other factors such as number of transfusions, age, sex and panty need to be examined to provide accurate projections of risk in chronic transfusion.

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Section: Discussionmentioning

confidence: 99%

Alloantibody responses in multiply transfused sickle cell patients

et al. 1987

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“…A combined relative incidence analysis (Woolf 1955) performed on data from four independent studies (Brain & Hammond 1974, van Rood et al 1975, Murray et al 1976, Darke 1977) showed a small but consistent increase in the HLA-A3 antigen in females who responded to the Rhesus-D antigen during pregnancy (Darke 1977). However, no disturbance in HLA-A or B antigen frequencies in deliberately immunized male volunteers has been observed (Petranyi et al 1974, Dausset & Hors 1975, Darke 1977 To further investigate the possible relationship between the HLA system and immune responsiveness, HLA-DR and properdin factor B (Bf) typing has been performed on responders and non-responders to the D antigen.…”

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confidence: 99%

HLA‐DR antigens and properdin factor B allotypes in responders and non‐responders to the Rhesus‐D antigen

et al. 1983

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“…In a 1974 study of previously pregnant White South African women, Brain and colleagues reported that nonresponders to D tended not to form anti-HLA antibodies, and women sensitized to D tended to be HLA sensitized as well. 33 All LAPS subjects were volunteer blood donors. Typically, individuals who test positive for non-ABO anti-RBC antibodies are excluded from donating blood.…”

Section: Discussionmentioning

confidence: 99%

Does Rh immune globulin suppress HLA sensitization in pregnancy?

et al. 2012

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BACKGROUND How Rh immune globulin (RhIG) prevents sensitization to D antigen is unclear. If RhIG Fc delivers a nonspecific immunosuppressive signal, then RhIG may inhibit sensitization to antigens other than D. HLA antibody prevalence was compared in previously pregnant RhD negative versus RhD positive women to investigate whether RhIG suppresses HLA sensitization. STUDY DESIGN AND METHODS In the Leukocyte Antibody Prevalence Study (LAPS)1, 7,920 volunteer blood donors were screened for anti-HLA antibodies and surveyed about prior pregnancies and transfusions. A secondary analysis of the LAPS database was performed. RESULTS RhD negative women ≤40 years old (presumed to have received antenatal ± postpartum RhIG in all pregnancies) had a significantly lower HLA sensitization rate than RhD positive women (RR 0.58, 95% CI 0.40–0.83). When stratified by deliveries (1, 2, 3, or ≥4), RhD negative women ≤40 were HLA sensitized less often than RhD positive women in every case. In contrast, a clear relationship between RhD type and HLA sensitization was not seen in older previously pregnant women whose childbearing years are presumed to have preceded the use of routine RhIG prophylaxis. In a multivariable logistic regression model, RhD negative women ≤40 years old remained significantly less likely to be HLA sensitized compared with RhD positive women after adjusting for parity, time from last pregnancy, lost pregnancies, and transfusions (OR 0.55, 95% CI 0.34–0.88). CONCLUSION Consistent with a nonspecific immunosuppressive effect of RhIG, younger previously pregnant RhD negative women were less likely than previously pregnant RhD positive women to be HLA sensitized.

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Association between histocompatibility type and the ability to make anti‐Rh antibodies

Cited by 14 publications

References 5 publications

Alloantibody responses in multiply transfused sickle cell patients

Alloantibody responses in multiply transfused sickle cell patients

HLA‐DR antigens and properdin factor B allotypes in responders and non‐responders to the Rhesus‐D antigen

Does Rh immune globulin suppress HLA sensitization in pregnancy?

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