HLA‐DR antigens and properdin factor B allotypes in responders and non‐responders to the Rhesus‐D antigen

Darke, C.; Street, J.; Sargeant, C.; Dyer, Philip A.

doi:10.1111/j.1399-0039.1983.tb00180.x

Cited by 17 publications

(4 citation statements)

References 9 publications

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“…A general analysis of this population according to sex indicated that women were more likely to produce red cell antibody than men (63% of women vs 46% of men). Similar increased immune responsiveness in women had been seen in the National Sickle Cell program and in other studies (Orlina et al 1978, Dutcher et al 1981, Darke et al 1983). Analysis of data with distinction between multiparous and nulliparous women ( Table 2) indicated that nulliparous females showed a greater level of red cell antibody formation at all levels of transfusion than either males or parous females (p = 0.012 and p = 0.010, respectively).…”

Section: Effect Of Transfusion and Sexlparity On Antibody Responsessupporting

confidence: 78%

“…Although greater innate female responsiveness has been noted by others (Orlina et al 1978, Dutcher et al 1981, Darke et al 1983), the distinction between nulliparous and multiparous females was surprising. We feel that the apparently increased risk for red cell sensitization in nulliparous females in this study should be interpreted with caution.…”

Section: Discussionmentioning

confidence: 83%

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Alloantibody responses in multiply transfused sickle cell patients

et al. 1987

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Fifty-six adult and 15 pediatric black patients with sickle cell disease were studied to determine their antibody responses to repeated transfusions of red cells. Red cell antibodies were determined restrospectively; anti-lymphocyte antibodies (class I and 11) were determined on the single, most recently drawn blood sample. All adults were HLA-A, B, C, DR and DQ typed. Ten percent of the individuals with less than SO transfusions, but greater than 50% with 100 transfusions or more, had red cell antibodies. The percentage of patients producing anti-red cell antibodies increased consistently with the number of transfusions (p = 0.0062). Women were more likely to become sensitized to red cell antigens than men (p = 0.008), and nulliparous women more likely than multiparous women. Children were also sensitized to red cell antigens (20%). and to a high degree to lymphocyte antigens (73%). No HLA association was found with increased propensity to red cell sensitization. A weak association of HLA DRS and DR7 with failure to become sensitized to lymphocyte alloantigens was observed, but did not reach statistical significance. Our results suggest that. while genetic factors influencing transfusion response almost certainly exist, other factors such as number of transfusions, age, sex and panty need to be examined to provide accurate projections of risk in chronic transfusion.

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Section: Effect Of Transfusion and Sexlparity On Antibody Responsessupporting

confidence: 78%

Section: Discussionmentioning

confidence: 83%

Alloantibody responses in multiply transfused sickle cell patients

et al. 1987

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“…Numerous studies attempted to determine MHC determinants for anti‐D immunization and higher frequencies as well as frequencies equal to controls of DRB1*15 and DQB1*02 (genetically linked to DRB1*03) alleles were reported 1,20‐22. In our study, anti‐D was predominantly pregnancy induced and single D antibodies were associated with DRB1*01 and DRB1*11 and less strongly with DRB1*03 while a DRB1*15 association was only found in multiple specificity responders, with or without anti‐D.…”

Section: Discussionmentioning

confidence: 50%

HLA‐DRB1 associations in individuals with single and multiple clinically relevant red blood cell antibodies

et al. 2014

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“…First et al (1977) reported the hyperacute rejection of renal allografts in man due to those cross-reacting antibodies against streptococci. Darke et al (1983) reported ii significant correlation between DRw6 and the immune response to the Rhesus-D antigen in males. Wojtulewicz-Kurkus et al (1981) reported that among a group of individuals who were deliberately immunized against Rhesus-D. all of the DRw6 positive ones belong to the responder group.…”

Section: Hla-drw6 As a Marker For Immune Responsivenessmentioning

confidence: 96%