Association between Helicobacter pylori infection and dementia

Huang, Wei-Shih; Yang, Tse-Yen; Shen, Wei‐Chih; Lin, Cheng‐Li; Lin, Ming-Chia; Kao, Chia‐Hung

doi:10.1016/j.jocn.2013.11.018

Cited by 54 publications

(39 citation statements)

References 18 publications

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“…The majority of pathological changes in AD patients, including inflammation, brain atrophy, immune abnormalities, amyloid formation, changes of gene expression and cognitive impairment, are all considered to be associated with microbial infections (Bhattacharjee and Lukiw, 2013;Heintz and Mair, 2014;Huang et al, 2014;Mancuso et al, 2014;Miklossy, 2011). Gut microbiota and host form the complex of mutualistic symbiosis in normal conditions and the symbiotic environment can effectively suppress the infection of potential pathogenic microorganisms.…”

Section: Microbial Infection and Admentioning

confidence: 99%

Alzheimer’s disease and gut microbiota

Wang

Jin

2016

Sci. China Life Sci.

293

188

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Section: Microbial Infection and Admentioning

confidence: 99%

Alzheimer’s disease and gut microbiota

Wang

Jin

2016

Sci. China Life Sci.

293

188

View full text Add to dashboard Cite

“…56,60 Other clinical data suggest an association between hospitalization with pneumonia and increased risk of dementia, 57 as well as an association between Helicobacter pylori infection and dementia. 58 …”

Section: Clinical Factors Influencing Infection Risk and Presentatmentioning

confidence: 99%

Influence of Aging and Environment on Presentation of Infection in Older Adults

Chakhtoura

Bonomo

Jump

2017

Infectious Disease Clinics of North America

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Synopsis In older adults, pathophysiologic, clinical, and environmental factors all affect the presentation of infections. We explore how age-related changes influence the manifestation and evaluation of infections in this population. Specific topics include immunosenescence, age related organ-specific physiologic changes, and frailty. We also describe clinical factors influencing infection risk and presentation in older adults including temperature regulation, cognitive decline, and malnutrition. Finally, we discuss the influence of the setting in which older adults reside on the clinical evaluation of infection. Understanding the influence of all these changes may facilitate the prevention, early recognition and treatment of infections in older adults.

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“…The etiology and pathogenesis of dementia is unknown, although several studies have reported that infections or inflammatory processes such as hepatitis C viral infection, Helicobacter pylori infection, chronic osteomyelitis or even sepsis can increase the risk of developing dementia [19,20,21,22]. Inflammatory changes in the brain have also been reported in studies on the pathogenesis of dementia [23,24,25].…”

Section: Introductionmentioning

confidence: 99%

Are Chronic Periodontitis and Gingivitis Associated with Dementia? A Nationwide, Retrospective, Matched-Cohort Study in Taiwan

et al. 2016

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Background: Chronic periodontitis and gingivitis are associated with various diseases; however, their impact on dementia is yet to be elucidated. This study is aimed at investigating the association between chronic periodontitis and gingivitis, and the risk of developing dementia. Methods: A total of 2,207 patients, with newly diagnosed chronic periodontitis and gingivitis between January 1, 2000 and December 31, 2000, were selected from the National Health Insurance Research Database of Taiwan, along with 6,621 controls matched for sex and age. After adjusting for confounding factors, Cox proportional hazards analysis was used to compare the risk of developing dementia during the 10-year follow-up period. Results: Of the study subjects, 25 (1.13%) developed dementia compared to 61 (0.92%) in the control group. Cox proportional hazards regression analysis revealed that the study subjects were more likely to develop dementia (hazard ratio (HR) 2.085, 95% CI 1.552-4.156, p < 0.001). After adjusting for sex, age, monthly income, urbanization level, geographic region, and comorbidities, the HR for dementia was 2.54 (95% CI 1.297-3.352, p = 0.002). Conclusions: Patients with chronic periodontitis and gingivitis have a higher risk of developing dementia. However, further studies on other large or national data sets are required to support the current findings.

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Association between Helicobacter pylori infection and dementia

Cited by 54 publications

References 18 publications

Alzheimer’s disease and gut microbiota

Alzheimer’s disease and gut microbiota

Influence of Aging and Environment on Presentation of Infection in Older Adults

Are Chronic Periodontitis and Gingivitis Associated with Dementia? A Nationwide, Retrospective, Matched-Cohort Study in Taiwan

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