Association between height and thyroid cancer risk: A meta-analysis of prospective cohort studies

Jing, Zhaohai; Hou, Xu; Liu, Ying; Yan, Shushan; Wang, Robin; Zhao, Shihua; Wang, Yangang

doi:10.1002/ijc.29487

Cited by 16 publications

(19 citation statements)

References 23 publications

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“…We also found that maternal height was positively associated with higher risk of thyroid cancer overall and both papillary and follicular subtypes. This finding is consistent with previous studies reporting that taller children 4 or adults 5 have a modestly increased risk of thyroid cancer in adulthood. However, we found no association between adult weight or BMI and risk of thyroid cancer, consistent with a previous study of Swedish men, 41 but in contrast to a number of studies in other populations.…”

Section: Discussionsupporting

confidence: 93%

“…2 In most countries, known risk factors such as ionizing radiation and genetic syndromes account for a minority of cases, 3 which has prompted investigations of other factors that potentially could facilitate the identification of high-risk subgroups. A number of studies have reported that increased height or body mass index (BMI) in either childhood 4 or adulthood [5][6][7][8][9][10] is associated with a modestly increased risk of adult thyroid cancer, possibly related to growth factor pathways involving insulin-like growth factor I (IGF-I). 11,12 IGF-I is known to have procarcinogenic properties and to be produced locally in thyroid cancer cells.…”

mentioning

confidence: 99%

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Fetal growth and subsequent maternal risk of thyroid cancer

Crump

Sundquist

Sieh

et al. 2015

Intl Journal of Cancer

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Thyroid cancer has peak incidence among women of reproductive age, and growth factors, which have procarcinogenic properties, may play an important etiologic role. However, the association between fetal growth rate during a woman’s pregnancy and her subsequent risk of thyroid cancer has not been previously examined. We conducted a national cohort study of 1,837,634 mothers who had a total of 3,588,497 live-births in Sweden in 1973-2008, followed up for thyroid cancer incidence through 2009. There were 2,202 mothers subsequently diagnosed with thyroid cancer in 36.8 million person-years of follow-up. After adjusting for maternal age, height, weight, smoking, and sociodemographic factors, high fetal growth (birth weight standardized for gestational age and sex) was associated with a subsequent increased risk of thyroid cancer in the mother (incidence rate ratio [IRR] per additional 1 standard deviation, 1.05; 95% CI, 1.01-1.09; P=0.02). Each 1,000 g increase in the infant’s birth weight was associated with a 13% increase in the mother’s subsequent risk of thyroid cancer (IRR, 1.13; 95% CI, 1.05-1.22; P=0.001). These findings appeared to involve both papillary and follicular subtypes, and did not vary significantly by the mother’s height, weight, or smoking status. In this large national cohort study, high fetal growth during a woman’s pregnancy was independently associated with a subsequent increased risk of her developing thyroid cancer. If confirmed, these findings suggest an important role of maternal growth factors in the development of thyroid cancer, and potentially may help facilitate the identification of high-risk subgroups of women.

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Section: Discussionsupporting

confidence: 93%

mentioning

confidence: 99%

Fetal growth and subsequent maternal risk of thyroid cancer

Crump

Sundquist

Sieh

et al. 2015

Intl Journal of Cancer

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“…Because height is used to calculate BMI and has been associated with PTC risk in previous studies 29,30 , we also repeated all analyses using sex-specific quartiles of height as an independent variable.…”

Section: Discussionmentioning

confidence: 99%

Adolescent overweight and obesity and the risk of papillary thyroid cancer in adulthood: a large-scale case-control study

Kim

Hwang

Kim

et al. 2020

Sci Rep

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this study aimed to investigate the association between adolescent overweight and obesity and ptc risk in adulthood. We conducted a case-control study in the Republic of Korea with 1,549 PTC patients and 15,490 controls individually matched for age and sex. We estimated body mass index (BMI) at age 18 years from self-reported weight at this age. Compared with BMI < 23.0 at age 18 years, BMI ≥ 25.0 at age 18 years was associated with higher PTC risk (odds ratio [OR] = 4.31, 95% confidence interval [CI]: 3.57, 5.22). The association between BMI ≥ 25.0 at age 18 years and PTC risk was stronger among men (OR = 6.65, 95% CI: 4.78, 9.27) than among women (OR = 3.49, 95% CI: 2.74, 4.43), and stronger among individuals with current BMI ≥ 25.0 (OR = 8.21, 95% CI: 6.34, 10.62) than among those with current BMI < 25.0 (OR = 2.21, 95% CI: 1.49, 3.27). Among PTC patients, BMI ≥ 25.0 at age 18 years was associated with extra-thyroidal extension and T stage ≥2, but not with N stage ≥1 or BRAF V600E mutation. Adolescent overweight and obesity was associated with higher risk of ptc in adulthood. our results emphasise the importance of weight management in adolescence to decrease the ptc risk. conclusionWe found that adolescent overweight and obesity was associated with higher risk of PTC. The association was stronger among men than women and stronger among individuals with current BMI ≥ 25 than those with current BMI < 25. Adolescent overweight and obesity was also associated with higher tumour aggressiveness among PTC patients. The results of the present study provide additional evidence that public health concerns and policy intervention are needed for weight management in adolescence to decrease the PTC risk.

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“…The association between height and thyroid cancer incidence could be explained partially by the effect of insulin-like growth factor (IGF-1). Previous studies reported a positive association between the level of IGF-1 and the risk of thyroid cancer incidence [1,26]. Higher IGF-1 levels promote mutation in various cell lines including thyroid cells [1,21,26,27] and contribute to increased risk of cancer incidence by stimulating cell proliferation, adhesion, and migration, and by inhibiting apoptosis [1, Thyroid Cancer and Anthropometric Factors in the Japanese Population J. Sado et al 21,27].…”

Section: Discussionmentioning

confidence: 99%

Risk of thyroid cancer in relation to height, weight, and body mass index in Japanese individuals: a population‐based cohort study

et al. 2018

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Greater height and body mass index (BMI) have been associated with an increased risk of thyroid cancer incidence in Western countries. However, few epidemiological studies have assessed the association between anthropometric factors, such as BMI, height, or weight, and thyroid cancer incidence in Asian populations. Using the population‐based Japan Public Health Center‐based prospective study database, we investigated the relationship between anthropometric factors and thyroid cancer incidence. Data on anthropometric factors were collected through a self‐administered questionnaire at baseline. The hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using the Cox proportional hazards model, and the exposure level was categorized into quintiles. A total of 49,062 men and 53,661 women enrolled between 1990 and 1994 were included in our analyses, and 191 cases (37 in men and 154 in women) of thyroid cancer were identified, with 1,695,702 person‐years of follow‐up until 2010. Compared with the male group with height ≤160 cm, HRs of the male groups with height 165–168 cm and ≥169 cm were 3.92 (95% CI; 1.33–11.55, P = 0.013) and 4.24 (95% CI; 1.32–13.61, P = 0.015), respectively, and the HR per 5‐cm increase in height was 1.12 (95% CI 1.06–1.18, P < 0.001). In contrast, the association between anthropometric features and the risk of thyroid cancer did not significantly differ among women. In this population, an increase in risk for increased height was observed in men, but no associations between anthropometric indexes and thyroid cancer risk were observed in women.

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Association between height and thyroid cancer risk: A meta-analysis of prospective cohort studies

Cited by 16 publications

References 23 publications

Fetal growth and subsequent maternal risk of thyroid cancer

Fetal growth and subsequent maternal risk of thyroid cancer

Adolescent overweight and obesity and the risk of papillary thyroid cancer in adulthood: a large-scale case-control study

Risk of thyroid cancer in relation to height, weight, and body mass index in Japanese individuals: a population‐based cohort study

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