Association between heavy metals and metalloids in topsoil and mental health in the adult population of Spain

Ayuso-Álvarez, Ana; Simón, Lorena; Núñez, Olivier; Rodríguez‐Blázquez, Carmen; Martín-Méndez, Iván; Bel‐lan, A.; López‐Abente, Gonzalo; Merlo, Juan; Fernández-Navarro, Pablo; Galán, Iñaki

doi:10.1016/j.envres.2019.108784

Cited by 29 publications

(13 citation statements)

References 38 publications

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“…Some species of medicinal plants accumulate metal (loid)s in their composition that can cause health damage ( Street, 2012 ; Rocha et al, 2019 ). The anxiety and depression may be related to a plausible high exposure to heavy metals in the contaminated areas, which are specifically industrialized zones ( Jaga and Dharmani, 2007 ; Ayuso-Álvarez et al, 2019 ). In addition, there is a relationship between exposure to heavy metals and anxiety ( Berk et al, 2014 ; Theorell et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Human Health Risk Assessment of Heavy Metals and Metalloids in Herbal Medicines Used to Treat Anxiety: Monitoring of Safety

et al. 2021

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The present study estimated the human health risk assessment and daily intake of heavy metals and metalloids in herbal medicines used to treat anxiety in Brazil. Six different brands of herbal medicines were purchased in the city of Campo Grande/MS, Brazil: Pasalix®, Calman®, Serenus®, Maracugina®, Prakalmar® and Calmasyn®. In total, eight elements including As, Ba, Cd, Co, Cr, Cu, Fe, and Pb were analyzed using optical emission spectrometry with inductively coupled plasma (ICP OES). Only the concentration of As in the herbal medicine Prakalmar® is above the values established by United States Pharmacopoeia Convention (USP) and Brazilian Pharmacopoeia (BF) for permitted concentration of elemental impurities in drugs substances. The concentration of Ba, Cd, Co, Cr and Cu in all herbal medicines are lower than the values set by USP and FB. The concentration of Pb in Calman® is lower than the limits established by BF, but higher than those established by USP. Pasalix, Serenus®, Calmasyn®, Prakalmar® and Marcacugina® have a higher Pb concentration than the values allowed by USP and BF. All herbal medications have concentrations within safe ranges for human consumption, with the exception of Calmasyn®, which has Pb over the value defined by USP for oral permissible daily exposure (PDE) for elemental impurities. The values of estimated daily intake (EDI) of metal (loid)s in adults and children obtained from the consumption of the herbal medicines are below the values stipulated by the minimal risk levels (MRLs). All the hazard index (HI) values recorded in this study were below 1. However, monitoring by regulatory agency is necessary, large doses of heavy metal may cause acute or chronic toxicities.

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Section: Introductionmentioning

confidence: 99%

Human Health Risk Assessment of Heavy Metals and Metalloids in Herbal Medicines Used to Treat Anxiety: Monitoring of Safety

et al. 2021

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“…Alvarez et al found that those who lived in locations with greater concentrations of heavy metals and metalloids in the soil had a higher likelihood of having a mental condition [ 13 ]. According to the CDC, there are no safe lead (Pb) blood levels [ 93 ].…”

Section: Impact Of Environmental Pollutants On Gut Dysbiosis and Ment...mentioning

confidence: 99%

“…Mice were exposed to BPA (50 mg/kg feed weight), 2 weeks prior to mating EE (0.1 ppb), or a control diet, and then continued on the diets throughout gestation and lactation. After pairing reproductive male partners were exposed to these diets until their offspring were weaned at PND30 Alvarez et al found that those who lived in locations with greater concentrations of heavy metals and metalloids in the soil had a higher likelihood of having a mental condition [13]. According to the CDC, there are no safe lead (Pb) blood levels [93].…”

Section: Heavy Metalsmentioning

confidence: 99%

“…Approximately 450 million people worldwide suffer from some type of psychiatric disorder that accounts for the loss of around one-third of the disability-free-life years [ 12 ]. Currently, mental ailments are a prominent cause of disability and morbidity worldwide [ 13 ]. Depression, anxiety, phobias, bipolar disorder, schizophrenia and other psychoses, dementia, and developmental disorders such as autism and post-traumatic stress disorder are all mental disorders with their own set of symptoms.…”

Section: Introductionmentioning

confidence: 99%

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Impact of Environmental Pollutants on Gut Microbiome and Mental Health via the Gut–Brain Axis

Singh¹,

Sharma²,

Pal³

et al. 2022

Microorganisms

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Over the last few years, the microbiome has emerged as a high-priority research area to discover missing links between brain health and gut dysbiosis. Emerging evidence suggests that the commensal gut microbiome is an important regulator of the gut–brain axis and plays a critical role in brain physiology. Engaging microbiome-generated metabolites such as short-chain fatty acids, the immune system, the enteric nervous system, the endocrine system (including the HPA axis), tryptophan metabolism or the vagus nerve plays a crucial role in communication between the gut microbes and the brain. Humans are exposed to a wide range of pollutants in everyday life that impact our intestinal microbiota and manipulate the bidirectional communication between the gut and the brain, resulting in predisposition to psychiatric or neurological disorders. However, the interaction between xenobiotics, microbiota and neurotoxicity has yet to be completely investigated. Although research into the precise processes of the microbiota–gut–brain axis is growing rapidly, comprehending the implications of environmental contaminants remains challenging. In these milieus, we herein discuss how various environmental pollutants such as phthalates, heavy metals, Bisphenol A and particulate matter may alter the intricate microbiota–gut–brain axis thereby impacting our neurological and overall mental health.

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“…What's more, HMs can enter and accumulate in surrounding people through the food chain, respiratory inhalation, skin contact and other routes of exposure (Cheng et al, 2020). Some HMs have strong toxic to human organs even in trace amounts, which increases the risk of serious physical diseases and mental illness (Ayuso-Alvarez et al, 2019;Li et al, 2019;. People living downstream of mine tailings may develop nervous system disturbance, pneumonia, kidney inflammation, sesophageal, liver and other cancers attributed to long-term consumption of vegetables, rice and drinking water contaminated with upstream HMs (Shu et al, 2018;Zhao et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Biochar enhanced phytostabilization of heavy metal contaminated mine tailings: A review

Shi

Zang

Yang

et al. 2022

Front. Environ. Sci.

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Mining activities has generated large amounts of mine tailings each year, and these tailings usually contain high concentrations of heavy metal pollutants, which not only cause serious damage to the local and surrounding soil ecosystems, but also harm human health via the transmission of food chain. Phytoremediation is treated as environmentally friendly, long-term effective and low-cost restoration method. However, tailing soil acidification, low organic matter content, poor water holding capacity and compaction make plant struggle to survive. Biochar, a soil conditioner can promote plant growth by improving the physical, chemical and biological properties of soil, thus strengthening the ability of phytoremediation in the contaminated tailings. This review elaborates how the physicochemical properties of biochar affect phytoremediation; and summarized how the raw materials of biochar affect the physicochemical characteristics. Finally, the future research directions are prospected.

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Association between heavy metals and metalloids in topsoil and mental health in the adult population of Spain

Cited by 29 publications

References 38 publications

Human Health Risk Assessment of Heavy Metals and Metalloids in Herbal Medicines Used to Treat Anxiety: Monitoring of Safety

Human Health Risk Assessment of Heavy Metals and Metalloids in Herbal Medicines Used to Treat Anxiety: Monitoring of Safety

Impact of Environmental Pollutants on Gut Microbiome and Mental Health via the Gut–Brain Axis

Biochar enhanced phytostabilization of heavy metal contaminated mine tailings: A review

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