Association between GPx‐1 polymorphisms and personality traits in healthy Chinese‐Han subjects

Shao, Xiaojun; Sun, Dongxue; Zhang, Bihui; Cheng, Lingfei; Yan, Ci; Zhu, Gang

doi:10.1002/brb3.1897

Cited by 3 publications

(3 citation statements)

References 68 publications

(81 reference statements)

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“…In antioxidant genes, increased levels of ROS and reduced enzymatic activity may occur due to functional polymorphisms that may confirm its role in contributing towards increasing risk of age-related disorders (Irfan et al 2016 ). Previous study conducted by Shao et al ( 2020 ) revealed that especially rs1800668 GPx-1 polymorphisms may affect GPx-1 promoter activity. In addition, C allele was shown to be associated with an increase in GPx activity which can help in improving antioxidant activity.…”

Section: Discussionmentioning

confidence: 93%

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Implication of noise exposure on hearing with emphasis to hOGG1 and GPx-1 polymorphisms and HO-1 protein among textile workers

Taha,

Samir Ellaithy,

Abd El-Aziz

et al. 2023

Environ Sci Pollut Res

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Noise exposure is a health hazard in the textile industry. In cochlear hair cells, DNA damage caused by 8-oxoguanine (8-oxo G) can result in noise-induced hearing loss. Human 8-hydroxyguanine glycosylase (hOGG1) is a DNA repair enzyme that excises (8-oxo G) in the DNA and repairs DNA damage. Glutathione peroxidase-1 (GPx) is a crucial antioxidant enzyme that aids in limiting cochlear damages. Heme oxygenase-1 (HO-1) is a stress-inducible protein with a high fold change in the hair cells of the cochlea. The study aimed to investigate the association of either hOGG1 and GPx-1 polymorphisms with audiometric notches and HO-1 protein among textile workers. hOGG1 and GPx genotypes were analyzed by PCR–RFLP, and HO-1 levels were measured by ELISA in 115 male textile workers. Blood pressure and audiogram were performed. Results recorded the relation between audiometric notches and ear complaints among workers. Older age workers showed audiometric notches at > 25 dB with a significant decrease in HO-1 levels and higher levels in workers with normal audiogram. Ser/Cys genotype of hOGG1 gene was associated with age and work duration while CC genotype of GPx is associated with HO-1 levels and diastolic pressure. Ser/Cys genotype of hOGG1 gene was associated with age while Cys/Cys genotype was associated with work duration among workers. CC genotype of GPx gene was associated with higher HO-1 levels and TT genotype was associated with high diastolic pressure. Finally, hearing impairment was dependent on the duration of exposure to noise, older age, and the presence of heterozygote TC genotype of GPx gene among textile workers.

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Section: Discussionmentioning

confidence: 93%

“…One of the five GPx homologues, GPx-1, represents the most distributed enzyme widely and especially in vascular endothelial cells (Forgione et al 2002 ). It can protect superiorly against SOD and CAT in cells exposed to ROS (Shao et al 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Implication of noise exposure on hearing with emphasis to hOGG1 and GPx-1 polymorphisms and HO-1 protein among textile workers

Taha,

Samir Ellaithy,

Abd El-Aziz

et al. 2023

Environ Sci Pollut Res

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“…In fact, several previous studies have demonstrated significant differences in defenses between the two genders ( 56 – 58 ), and in agreement, we found significant differences in 10 particular defense styles between male and female subjects in the present study. Moreover, the important effect of the interaction between gender and gene polymorphisms has already been demonstrated on individual differences in personality traits ( 59 – 61 ). Therefore, it was expected that our findings were mainly restricted to men.…”

Section: Discussionmentioning

confidence: 98%

Association of Neurotensin Receptor 1 Gene Polymorphisms With Defense Mechanisms in Healthy Chinese

Zhang³

et al. 2021

Front. Psychiatry

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Aims: In the central nerve system, neurotensin (NT), and neurotensin receptor 1 (NTR1) modulate the dopamine system. Gene variations in the dopamine system have been demonstrated to influence certain defense mechanisms, but no studies have investigated possible effect of NTR1 gene polymorphisms in the biological determination of these defenses. The present study therefore examined this link.Methods: In 412 healthy Han Chinese, single nucleotide polymorphisms rs6090453C/G, rs6011914C/G, and rs2427422A/G of the NTR1 gene were genotyped, and the defense mechanisms were measured by the self-reporting Defense Style Questionnaire 88.Results: Significant male-specific differences in the projective identification among the rs6090453 genotypes (p = 0.003); in the intermediate defense, reaction formation, and projective identification among the rs6011914 genotypes (p = 0.011, 0.010, and 0.011, respectively); and in the projective identification among the rs2427422 genotypes (p = 0.005) were found when the level of significance was adjusted by the Bonferroni correction. There was no significant difference in any of the defense scores among genotypes of any single nucleotide polymorphism in the total cohort or female subjects (all p > 0.017). The distributions of genotypes between the low and high score subgroups showed significant differences in the rs2427422 genotype distributions for help-rejecting complaining, regression, and projective identification (p = 0.010, 0.022, and 0.044, respectively). Significant differences were found between males and females in 10 defense mechanisms (all P < 0.05).Conclusions: The gene variations in the NTR1 polymorphisms were involved in the biological mechanisms of intermediate defense mechanisms, and this effect was influenced by sex.

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