Association between genetic polymorphisms of glutathione S-transferase M1/T1 and psoriasis in a population from the area of the strict of messina (Southern Italy)

Guarneri, Fabrizio; Sapienza, Daniela; Papaianni, Valeria; Marafioti, Ilenia; Guarneri, Claudio; Mondello, Cristina; Roccuzzo, Salvatore; Asmundo, Alessio; Cannavò, Serafinella Patrizia

doi:10.1080/10715762.2019.1698738

Cited by 10 publications

(11 citation statements)

References 35 publications

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“…However, as already mentioned, maintaining the redox equilibrium is a multifactorial process of which GSTs are only a part, whose importance may vary depending on the interplay between all factors. It is well known that the GSTM1 null and the GSTT1 null genotypes are frequent in the general population, but with significant worldwide variability [58][59][60], and their role and "relative weight" as risk factors for several dermatologic conditions may range from irrelevant to highly significant, depending on the population studied [10,11,[58][59][60][61][62][63][64][65]. Similar considerations may be applied to GSTP1 polymorphisms [66,67].…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress and Atopic Dermatitis

et al. 2020

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Atopic dermatitis is a common chronic/chronically relapsing inflammatory skin disease, with increasing worldwide prevalence. Etiopathogenesis is complex and multifactorial, with a mix of genetic, immunological and environmental aspects. Like in other chronic inflammatory diseases, oxidative stress plays an important pathogenetic role. We reviewed in vivo research studies on humans about oxidative stress and atopic dermatitis. Although sometimes contrasting, overall, they suggest that oxidative stress may have a significant role in atopic dermatitis, but our understanding is still incomplete, at least concerning in vivo data, because of limitations of available literature. Research consists of 33 papers published in 28 years, was not always performed on large study populations, represents a limited number of countries and ethnicities—not always in proportion to their size—and is scattered over multiple papers that, in the majority of cases, cannot be pooled and/or compared because many biomarkers were studied, in different tissues and with different methods. Further, larger studies appear warranted and necessary to shed more light on this aspect of atopic dermatitis, which is important not only to improve our understanding of this disease, but also for potential clinical and therapeutic implications.

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Section: Discussionmentioning

confidence: 99%

Oxidative Stress and Atopic Dermatitis

et al. 2020

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“…A total of eight studies evaluated polymorphisms in genes encoding markers or enzymes of oxidative stress, such as: glutathione S-transferase/gluyathione, paraoxonase 1, malondialdehyde, arylesterase, apolipoprotein B (APOB), apolipoprotein A1 (APOA1), methylentetrahydrofolatereductase (MTHFR), vascular adhesion protein-1 (VAP-1), superoxide dismutase 1, superoxide dismutase 2, nuclear factor erythroid 2 like 2 (NFE2L2), cytochrome b-245 beta chain (CYBB), interleukin-17 (IL-17), lipoprotein (a) [LP(a)], tumor necrosis factor-α (TNF-α), interleukin-10 (IL-10), N-acetyltransferase (N-AT), endothelial nitric oxide synthase (eNOS), cationic amino acid transporters (CATs), receptor for advanced glycation-end products (RAGE) and glutathione S-transferase [ 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 ]. Table 2 summarizes the information presented in the aforementioned studies.…”

Section: Resultsmentioning

confidence: 99%

“…Guarneri et al assessed the frequency of glutathione S-transferase M1/glutathione S-transferase T1(GSTM1/GSTT1) polymorphisms in 148 individuals with psoriasis versus 148 age-matched healthy counterparts, revealing that both glutathione S-transferase T1 null and GSTM1/GSTT1 “double null” genotypes are associated with psoriasis. Moreover, the association between this ailment and glutathione S-transferase T1 null was stronger in women versus men [ 68 ].…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, in terms of paraoxonase-1 gene polymorphisms, it was observed that the presence of the rs662 polymorphism (A > G) is more frequently associated with the development of psoriasis ( p = 0.004), with affected cases being most likely carriers of the heterozygous form A/G ( p = 0.003). In addition, the G rs662 allele (A > G) was more commonly encountered in individuals suffering from this disorder ( p = 0.003), emphasizing the role this allele could play in increasing one’s susceptibility of psoriasis [ 68 ].…”

Section: Resultsmentioning

confidence: 99%

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The Involvement of Oxidative Stress in Psoriasis: A Systematic Review

et al. 2022

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Psoriasis is a chronic, immune-mediated inflammatory dermatosis characterized by the appearance of erythematous plaques, covered by white scales, occasionally pruritogenic, and distributed mainly on the extensor areas. Oxidative stress is defined as an imbalance or a transient or chronic increase in the levels of free oxygen/nitrogen radicals, either as a result of the exaggerated elevation in their production or the decrease in their ability to be eliminated by antioxidant systems. Although the pathogenesis of psoriasis remains far from elucidated, there are studies that delineate an involvement of oxidative stress in this skin disorder. Thus, a systematic search was computed in PubMed/Medline, Web of Science and SCOPUS and, in total, 1293 potentially eligible articles exploring this research question were detected. Following the removal of duplicates and the exclusion of irrelevant manuscripts based on the screening of their titles and abstracts (n = 995), 298 original articles were selected for full-text review. Finally, after we applied the exclusion and inclusion criteria, 79 original articles were included in this systematic review. Overall, the data analyzed in this systematic review point out that oxidative stress markers are elevated in psoriasis and share an association with the duration and severity of the disease. The concentrations of these biomarkers are impacted on by anti-psoriasis therapy. In addition, the crosstalk between psoriasis and oxidative stress is influenced by several polymorphisms that arise in genes encoding markers or enzymes related to the redox balance. Although the involvement of oxidative stress in psoriasis remains undisputable, future research is needed to explore the utility of assessing circulating serum, plasma, urinary and/or skin biomarkers of oxidative stress and of studying polymorphisms in genes regulating the redox balance, as well as how can these findings be translated into the management of psoriasis, as well in understanding its pathogenesis and evolution.

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“…ROS can cause damage to many biomolecules in specific processes, including lipid peroxidation, and can stimulate the secretion of proinflammatory cytokines [15]. Other studies have demonstrated that a lack of enzymes or alterations of enzymes involved in the regulation of the oxidoreductive balance, such as glutathione S-transferase (GST) M1/T1 polymorphisms, may play a role in the complex pathogenetic mechanism of psoriasis, by reducing the antioxidant potential of the organism [16].…”

Section: Psoriasismentioning

confidence: 99%

Therapies with Antioxidant Potential in Psoriasis, Vitiligo, and Lichen Planus

et al. 2021

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Oxidative stress plays an important pathogenetic role in many chronic inflammatory diseases, including those of dermatological interest. In particular, regarding psoriasis, vitiligo, and lichen planus, excess reactive oxygen species and a decline in endogenous antioxidant systems are observed. In this regard, treatments with antioxidant properties could be appropriate therapeutic options. To date, clinical trials in dermatology on these treatments are limited. We reviewed the available studies on the efficacy of antioxidant therapies in psoriasis, vitiligo, and lichen planus. The role of herbal derivatives, vitamins, and trace elements was analyzed. The antioxidant properties of conventional therapies were also evaluated. Data from the literature suggest that antioxidants might be useful, but available studies on this topic are limited, heterogeneous, not completely standardized, and on small populations. Furthermore, in most cases, antioxidants alone are unable to induce significant clinical changes, except perhaps in mild forms, and must be used in conjunction with standard drug treatments to achieve measurable results. Further studies need to be conducted, considering larger populations and using internationally validated scales, in order to compare the results and clinical efficacy.

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Association between genetic polymorphisms of glutathione S-transferase M1/T1 and psoriasis in a population from the area of the strict of messina (Southern Italy)

Cited by 10 publications

References 35 publications

Oxidative Stress and Atopic Dermatitis

Oxidative Stress and Atopic Dermatitis

The Involvement of Oxidative Stress in Psoriasis: A Systematic Review

Therapies with Antioxidant Potential in Psoriasis, Vitiligo, and Lichen Planus

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