Association between fetuin-A levels with insulin resistance and carotid intima-media thickness in patients with new-onset type 2 diabetes mellitus

Abstract

Abstract. Fetuin-A, which is known to inhibit insulin signaling and pathological calcification, has emerged as a diabetes risk biomarker. In the present study, the association between the fetuin-A levels with insulin resistance (IR) and carotid intima-media thickness (CIMT) was investigated in patients with new-onset type 2 diabetes mellitus (nT2DM). A total of 100 patients with nT2DM (nT2DM group) and 100 normal glucose tolerance (NGT group) controls were evaluated. The serum fetuin-A level was measured by a commercial solid-phase ELISA kit. The estimate of IR was calculated by homeostasis model assessment (HOMA-IR). CIMT was measured by B-mode ultrasound. The association between the serum fetuin-A levels and the metabolic parameters was also analyzed. The serum fetuin-A levels were increased significantly in the nT2DM group compared to the NGT group (368.5±15.6 mg/ml vs. 152.7±7.1 mg/ml, P<0.01). Fetuin-A was positively correlated with HOMA-IR, CIMT, glycated hemoglobin, triglyceride, low-density lipoprotein cholesterol, body mass index, systolic blood pressure, fasting blood glucose and 2 h post-glucose load blood glucose (P<0.05 and P<0.01), but negatively correlated with fasting plasma insulin, 2 h plasma insulin after glucose overload, high-density lipoprotein cholesterol and HOMA-β-cell insulin secretion index (P<0.05 and P<0.01). To the best of our knowledge, the study demonstrated for the first time that there is a significant association between the serum fetuin-A levels with IR and CIMT in nT2DM. These results indicate that serum fetuin-A levels can be used as independent markers in the diagnosis of macroangiopathies in nT2DM.

Serum fetuin-A levels are associated with serum triglycerides before and 6 months after bariatric surgery

“…The previously reported positive association of circulating fetuin-A with BMI referred to populations with a wide range of BMI, including not only obese patients, but also lean or overweight individuals. [6][7][8][9] Thus, the fact that our study only evaluated subjects with BMI ≥35 kg/m 2 may have limited the potential for detection of significant associations between circulating fetuin-A and indices of obesity across the relatively narrow range of BMI of our study. Similarly, Himmetoglu et al found that although circulating fetuin-A was higher in morbidly obese patients compared with lean or overweight controls, it was not correlated with BMI in the subgroup of morbidly obese individuals.…”

“…Regarding the relationship of circulating fetuin-A with body weight status, although most of the studies have found a positive association between circulating fetuin-A and body mass index (BMI) and a reduction of serum fetuin-A levels after weight loss, some studies reported conflicting results. [6][7][8][9][10][11][12][13][14][15][16] Bariatric surgery is a weight loss intervention achieved via an alteration not only of the passage of food through the gastrointestinal tract, but also of the secretion of gut hormones regulating appetite. 17 Moreover, among weight loss interventions the magnitude of weight reduction after bariatric surgery is by far the greatest.…”

Serum fetuin-A levels in subjects with and without choroid plexus calcification

“…In an another study, authors found increased levels of fetuin-A in patients with new onset type 2 diabetes mellitus compared with individuals who had normal glucose tolerance test. They also found correlation between serum fetuin-A levels and glycated insulin [25]. For being an important mediator in calcified matrix metabolism, fetuin-A is also associated with bone mineral density.…”

Protective effect of thymoquinone improves cardiovascular function, and attenuates oxidative stress, inflammation and apoptosis by mediating the PI3K/Akt pathway in diabetic rats

“…Diabetes mellitus (DM) is a type of chronic metabolic disease involving the interaction of genetic and environmental factors. It is characterized by dysinsulinism, insulin resistance (IR) and disorders of the blood sugar, lipid and protein metabolisms (1). An increase in the prevalence rate of DM in China is reported to be due to the economic development and increase in the average life expectancy (2).…”