Association between family history of prostate and breast cancer among African-American men with prostate cancer

Beebe‐Dimmer, Jennifer L.; Drake, Elizabeth A.; Dunn, Rodney L.; Bock, Cathryn H.; Montie, James E.; Cooney, Kathleen A.

doi:10.1016/j.urology.2006.06.028

Cited by 15 publications

(23 citation statements)

References 19 publications

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“…affected father or/and brother(s), was based on 19 case-control [30], [57]–[60], [62]–[68], [70]–[72], [74]–[77], 3 nested case-control [7], [80], [82] and 4 cohort studies [6], [49], [78], [81]. 18 independent studies [6], [30], [49], [55]–[57], [60], [61], [63]–[66], [70], [71], [73], [75], [78], [81] provided data for men with history of prostate cancer in father and 16 [6], [30], [49], [57], [61], [63]–[66], [70], [71], [73], [75], [78], [79], [81] for men with history of prostate cancer in a brother(s). The combined estimate for history of prostate cancer in a second-degree relative was based on 5 studies [7], [58], [64], [66], [70].…”

Section: Resultsmentioning

confidence: 99%

“…When there was a population overlap between studies using a different design, the cohort study [6] was preferred over the case-control studies [50]–[53], and the nested case-control study [7] over the study of West et al [54]. A summary of the 25 case-control studies [30], [33], [55]–[77] and 8 cohort-based studies [6], [7], [49], [78]–[82] included in the analysis is presented in Table 1 and Table 2.…”

Section: Methodsmentioning

confidence: 99%

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An Epidemiological Reappraisal of the Familial Aggregation of Prostate Cancer: A Meta-Analysis

2011

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Studies on familial aggregation of cancer may suggest an overall contribution of inherited genes or a shared environment in the development of malignant disease. We performed a meta-analysis on familial clustering of prostate cancer. Out of 74 studies reporting data on familial aggregation of prostate cancer in unselected populations retrieved by a Pubmed search and browsing references, 33 independent studies meeting the inclusion criteria were used in the analysis performed with the random effects model. The pooled rate ratio (RR) for first-degree family history, i.e. affected father or brother, is 2.48 (95% confidence interval: 2.25–2.74). The incidence rate for men who have a brother who got prostate cancer increases 3.14 times (CI:2.37–4.15), and for those with affected father 2.35 times (CI:2.02–2.72). The pooled estimate of RR for two or more affected first-degree family members relative to no history in father and in brother is 4.39 (CI:2.61–7.39). First-degree family history appears to increase the incidence rate of prostate cancer more in men under 65 (RR:2.87, CI:2.21–3.74), than in men aged 65 and older (RR:1.92, CI:1.49–2.47), p for interaction = 0.002. The attributable fraction among those having an affected first-degree relative equals to 59.7% (CI:55.6–63.5%) for men at all ages, 65.2% (CI:57.7–71.4%) for men younger than 65 and 47.9% (CI:37.1–56.8%) for men aged 65 or older. For those with a family history in 2 or more first-degree family members 77.2% (CI:65.4–85.0%) of prostate cancer incidence can be attributed to the familial clustering. Our combined estimates show strong familial clustering and a significant effect-modification by age meaning that familial aggregation was associated with earlier disease onset (before age 65).

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

An Epidemiological Reappraisal of the Familial Aggregation of Prostate Cancer: A Meta-Analysis

2011

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“…Criteria for prostate biopsy in PRAP have changed over time. Prior to November 2005, criteria for prostate biopsy were (1) PSA > 4 ng/mL, (2) PSA 2.0-4.0 with fPSA less than 27%, (3) any abnormality on DRE, or (4) PSAv of 0.75 ng/mL/year. Since PCA detection rates have been high with these criteria (16), the criteria for prostate biopsy were lowered after November 2005 to detect earlier changes in screening parameters.…”

Section: Methodsmentioning

confidence: 99%

“…In addition, PCA in Black men has been reported to be more aggressive (3). Most reports in the literature have focused on quantifying the risk for PCA in Black men based on FH, genetic factors, or epidemiologic factors in case-control studies or from hereditary cohorts (2, 4-8). While quantification of PCA risk in Black men is essential, the impact of PCA in these families in the community can be more fully understood if the familial prevalence of PCA is characterized.…”

Section: Introductionmentioning

confidence: 99%

“…While quantification of PCA risk in Black men is essential, the impact of PCA in these families in the community can be more fully understood if the familial prevalence of PCA is characterized. Estimates of PCA prevalence in Black families have been described in the control arms of previous reports (2, 4-8), but not from a prospective cohort of Black men enrolled in a PCA screening program.…”

Section: Introductionmentioning

confidence: 99%

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Substantial family history of prostate cancer in black men recruited for prostate cancer screening

Mastalski

Coups

Ruth

et al. 2008

Cancer

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BACKGROUND. Black men are at increased risk for prostate cancer (PCA), particularly with a family history (FH) of the disease. Previous reports have raised concern for suboptimal screening of black men with an FH of PCA. The extent of FH of PCA are reported from a prospective, longitudinal PCA screening program for high‐risk men. METHODS. Black men ages 35 to 69 years are eligible for PCA screening through the Prostate Cancer Risk Assessment Program (PRAP) regardless of FH. Rates of self‐reported FH of PCA, breast, and colon cancer at baseline were compared with an age‐matched sample of black men from the 2005 National Health Interview Survey (NHIS) using standard statistical methods. RESULTS. As of January 2007, 332 black men with pedigree information were enrolled in PRAP and FH of PCA was compared with 838 black men from the 2005 NHIS. Black men in PRAP reported significantly more first‐degree relatives with PCA compared with black men in the 2005 NHIS (34.3% [95% confidence interval (95% CI), 29.2‐39.7] vs 5.7% [95% CI, 3.9‐7.4]). Black men in PRAP also had more FH of breast cancer compared with those in the 2005 NHIS (11.5% [95% CI, 8.2‐15.4] vs 6.3% [95% CI, 4.6‐8.0]). CONCLUSIONS. FH of PCA appears to be a motivating factor for black men seeking PCA screening. Targeted recruitment and education among black families should improve PCA screening rates. Efforts to recruit black men without an FH of PCA are also needed. Cancer 2008. © 2008 American Cancer Society.

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Familial clustering of breast and prostate cancer and risk of postmenopausal breast cancer in the Women's Health Initiative Study

Beebe‐Dimmer

Yee

Coté

et al. 2015

Cancer

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BACKGROUND Evidence suggests that the risk of breast and prostate cancer is increased among those with a family history of the same disease and particularly among first-degree relatives. However, less is known about the relationship between breast and prostate cancer within families and particularly among minority populations. METHODS Analyses of participants in the Women’s Health Initiative observational cohort who were free of breast cancer at the time of their baseline examination were conducted. Subjects were followed for breast cancer through August 31, 2009. A Cox proportional hazards regression modeling approach was used to estimate the risk of breast cancer associated with a family history of prostate cancer, breast cancer, and both among first-degree relatives. RESULTS There were 78,171 eligible participants, and 3506 breast cancer cases were diagnosed during the study period. A family history of prostate cancer was associated with a modest increase in breast cancer risk after adjustments for confounders (adjusted hazard ratio [aHR], 1.14; 95% confidence interval [CI], 1.02-1.26). In a separate analysis examining the joint impact of both cancers, a family history of both breast and prostate cancer was associated with a 78% increase in breast cancer risk (aHR, 1.78; 95% CI, 1.45-2.19). Risk estimates associated with a family history of both breast and prostate cancer were higher among African American women (aHR, 2.34; 95% CI, 1.09-5.02) versus white women (aHR, 1.66; 95% CI, 1.33-2.08). CONCLUSIONS These findings suggest that prostate cancer diagnosed among first-degree family members increases a woman’s risk of developing breast cancer. Future studies are needed to determine the relative contributions of genes and a shared environment to the risk for both cancers.

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Association between family history of prostate and breast cancer among African-American men with prostate cancer

Cited by 15 publications

References 19 publications

An Epidemiological Reappraisal of the Familial Aggregation of Prostate Cancer: A Meta-Analysis

An Epidemiological Reappraisal of the Familial Aggregation of Prostate Cancer: A Meta-Analysis

Substantial family history of prostate cancer in black men recruited for prostate cancer screening

Familial clustering of breast and prostate cancer and risk of postmenopausal breast cancer in the Women's Health Initiative Study

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