Association between environmental composite quality index score and obesity in children and their family: A cross-sectional study in northeast China

Liang, Hong; Zhang, Yixin; Zhang, Shen; He, Yu; Gao, Jie; Wang, Lining; Wang, Yuhan; Hua, Dong; Ma, Yanan

doi:10.1016/j.chemosphere.2022.134204

Cited by 4 publications

(2 citation statements)

References 42 publications

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“…ExWAS share conceptual similarity with genome-wide association studies that identify genetic risk markers that can be aggregated to quantify polygenic disease risk . Exposomic risk models have shown promise in explaining disease outcomes in various medical fields and are gaining interest in psychiatry . One advantage of exposomic risk models is that they may reveal how disparities in environmental burden are linked to heightened suicide risk among marginalized youth (eg, Black youth and sexual or gender minoritized youth).…”

Section: Introductionmentioning

confidence: 99%

Classification of Suicide Attempt Risk Using Environmental and Lifestyle Factors in 3 Large Youth Cohorts

Visoki,

Moore,

Zhang

et al. 2024

JAMA Psychiatry

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ImportanceSuicide is the third-leading cause of death among US adolescents. Environmental and lifestyle factors influence suicidal behavior and can inform risk classification, yet quantifying and incorporating them in risk assessment presents a significant challenge for reproducibility and clinical translation.ObjectiveTo quantify the aggregate contribution of environmental and lifestyle factors to youth suicide attempt risk classification.Design, Setting, and ParticipantsThis was a cohort study in 3 youth samples: 2 national longitudinal cohorts from the US and the UK and 1 clinical cohort from a tertiary pediatric US hospital. An exposome-wide association study (ExWAS) approach was used to identify risk and protective factors and compute aggregate exposomic scores. Logistic regression models were applied to test associations and model fit of exposomic scores with suicide attempts in independent data. Youth from the Adolescent Brain Cognitive Development (ABCD) study, the UK Millennium Cohort Study (MCS), and the Children’s Hospital of Philadelphia emergency department (CHOP-ED) were included in the study.ExposuresA single-weighted exposomic score that sums significant risk and protective environmental/lifestyle factors.Main Outcome and MeasureSelf-reported suicide attempt.ResultsA total of 40 364 youth were included in this analysis: 11 564 from the ABCD study (3 waves of assessment; mean [SD] age, 12.0 [0.7] years; 6034 male [52.2%]; 344 attempted suicide [3.0%]; 1154 environmental/lifestyle factors were included in the ABCD study), 9000 from the MCS cohort (mean [SD] age, 17.2 [0.3] years; 4593 female [51.0%]; 661 attempted suicide [7.3%]; 2864 environmental/lifestyle factors were included in the MCS cohort), and 19 800 from the CHOP-ED cohort (mean [SD] age, 15.3 [1.5] years; 12 937 female [65.3%]; 2051 attempted suicide [10.4%]; 36 environmental/lifestyle factors were included in the CHOP-ED cohort). In the ABCD discovery subsample, ExWAS identified 99 risk and protective exposures significantly associated with suicide attempt. A single weighted exposomic score that sums significant risk and protective exposures was associated with suicide attempt in an independent ABCD testing subsample (odds ratio [OR], 2.2; 95% CI, 2.0-2.6; P &lt; .001) and explained 17.6% of the variance (based on regression pseudo-R2) in suicide attempt over and above that explained by age, sex, race, and ethnicity (2.8%) and by family history of suicide (6.3%). Findings were consistent in the MCS and CHOP-ED cohorts (explaining 22.6% and 19.3% of the variance in suicide attempt, respectively) despite clinical, demographic, and exposure differences. In all cohorts, compared with youth at the median quintile of the exposomic score, youth at the top fifth quintile were substantially more likely to have made a suicide attempt (OR, 4.3; 95% CI, 2.6-7.2 in the ABCD study; OR, 3.8; 95% CI, 2.7-5.3 in the MCS cohort; OR, 5.8; 95% CI, 4.7-7.1 in the CHOP-ED cohort).Conclusions and RelevanceResults suggest that exposomic scores of suicide attempt provided a generalizable method for risk classification that can be applied in diverse samples from clinical or population settings.

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Section: Introductionmentioning

confidence: 99%

Classification of Suicide Attempt Risk Using Environmental and Lifestyle Factors in 3 Large Youth Cohorts

Visoki,

Moore,

Zhang

et al. 2024

JAMA Psychiatry

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“…Childhood obesity is a severe public health problem worldwide [ 1 ]. Despite increasing concern and awareness, the prevalence of childhood obesity remained high [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Relationship of 24-Hour Movement Behaviors with Weight Status and Body Composition in Chinese Primary School Children: A Cross-Sectional Study

Zhou

Liang

et al. 2022

IJERPH

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24 h movement behaviors, specifically physical activity (PA), sedentary behavior, and sleep, play a crucial role in the prevention and intervention of childhood obesity. This study aimed to examine the association of 24 h movement behaviors with weight status and body composition among Chinese primary school children. Using a random stratified sampling, 978 eligible participants (9.1 ± 1.4 years, 53.2% boys) were recruited from 1 May to 15 July 2021. Demographics included children’s age, gender, grade, parents’ education level, and household income. Movement behaviors were measured by validated self-reported scales. Weight status and body composition (percent of body fat, PBF; fat-free mass, FFM; skeletal muscle mass, SMM) were measured objectively. Results indicated that participants who were younger, boys, and at lower grade showed higher guidelines adherence. PA was inversely associated with PBF, while screen time (ST) was positively associated with overweight/obesity risk and FFM. Sleep showed no association with any health indicators. Meeting the behavioral guidelines was associated with better weight status and lower PBF, yet not with FFM and SMM. Interventions to improve the Children’s weight status and PBF should involve enhancing their overall movement behaviors and considering their demographic differences. More research on examining the association of movement guidelines adherence with body composition indicators is needed.

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Association of air pollution exposure with overweight or obesity in children and adolescents: A systematic review and meta–analysis

Zheng,

Zhang,

Shi

et al. 2024

Science of The Total Environment

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Association between environmental composite quality index score and obesity in children and their family: A cross-sectional study in northeast China

Cited by 4 publications

References 42 publications

Classification of Suicide Attempt Risk Using Environmental and Lifestyle Factors in 3 Large Youth Cohorts

Classification of Suicide Attempt Risk Using Environmental and Lifestyle Factors in 3 Large Youth Cohorts

Relationship of 24-Hour Movement Behaviors with Weight Status and Body Composition in Chinese Primary School Children: A Cross-Sectional Study

Association of air pollution exposure with overweight or obesity in children and adolescents: A systematic review and meta–analysis

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