Association between Dyslipidemia and Peritoneal Dialysis Technique Survival

Abstract

BACKGROUND:A large body of research has investigated the effects of pro-atherogenic lipid profile on cardiovascular diseases (CVD) in peritoneal dialysis (PD) patients. However, there is a general lack of research on the association between atherogenic dyslipidemia and PD technique survival.AIM:The study aimed to define the association between dyslipidemia and PD technique survival.METHODS:It was a prospective single-centre observational study involving 40 outpatients on continuous ambulatory PD treatment for more than 3 months between 2010 and 2016 in a single centre in Ukraine. There were 27 males and 13 females. The mean age of the participants was 49.3 ± 12.2 years. The primary outcome measures were all-cause technique failure.RESULTS:Atherogenic dyslipidemia was identified in 28/40 (70 %) patients and correlated with PD adequacy parameters. During the 36-month- follow-up period technique failure occurred in 2/12 (16.6 %) patients with atherogenic dyslipidemia compared with 12 / 28 (42.9 %) patients without atherogenic dyslipidemia (χ2 = 2.5; p = 0.12). In the univariate Cox regression model, atherogenic dyslipidemia at baseline was significantly associated with a higher risk of all-cause PD technique failure (HR 4.5; 95% CI 1.6 to 12.9; χ2 = 5.5, p = 0.019).CONCLUSION:The presence of atherogenic dyslipidemia was significantly associated with a higher risk of technique failure in PD patients. This is an important issue for future research. Further well-designed clinical trials are needed to determine the impact of dyslipidemia on PD adequacy and technique survival.

Arterial hypertension prevention as an actual medical and social problem

“…Considering that mental health is an integral part of the general health of people and together with mental well-being it is a high quality of life condition, the presence of mental disorders significantly affects the course of the disease, violating the subjective perception of the disease and reducing the effectiveness of treatment [4][5][6] . The structure of the causes of mortality in Ukraine remains constant: cardiovascular diseases remain in the first place -in 2015 this figure counted up to 404.6 thousand people, which correspond to 68% of total mortality [7][8][9][10] . According to the official statistics, over the past 25 years, the prevalence of cardiovascular diseases among the population of our country has increased by 3 times, and the mortality rate from them has increased by 45%.…”

Hyperuricemia Predicts Residual Diuresis Decline in Peritoneal Dialysis Patients

“…Our result indirectly confirmed the presence of chronic inflammation associated with an increased level of serum Creactive protein in hyperuricemic patients. Third, rapid decline of RRF could be associated with malnutrition or metabolic disorders in hyperuricemic PD patients [3,6,27,28]. There were significant differences in body mass indexes, phosphorous and triglyceride levels between the groups in this study.…”

“…However, the mean duration of PD treatment still does not exceed 5 years [1,2]. Residual diuresis (RD) has been shown to be an independent risk factor for oxidative stress aggravation, chronic inflammation, technique failure and increased mortality in PD patients [2][3][4][5][6].…”

Actual aspects of public health policy formation on the example of Ukraine

“…The first pilot projects on the development 25 . In the structure of non-infectious diseases mortality factors the main factors are diabetes [26][27][28] , cancer, chronic obstructive pulmonary diseases, cardiovascular diseases [29][30][31] . Key risk factors of non-infectious diseases are considered below (see scheme 1).…”