Arterial hypertension prevention as an actual medical and social problem

Abstract

Social changes, technological re-equipment, intensive formation of urban infrastructure have led to a constant increase in stress factors and an excessive growth of the nervous and psychological population burden. As a result of these processes in economically developed countries, acute diseases are becoming less and less significant, unlike the group of chronic disorders, such as arterial hypertension. Data from the review of the literature and the data we have received indicate that there is an increase in the level of cortisol in the blood in the phase of anxiety, which reduces in the resistance phase. A significant role is played by another hormone - insulin, which plays a key role in the development of the general adaptive syndrome. Through it the body implements numerous counter-defects in relation to the regulatory influence of catecholamines and cortisol. In conditions of prolonged stress, the level of insulin in the blood decreases and diabetes develops. The effect of cortisol and catecholamines in the resistance phase persists. The level of oxidative modification of blood plasma proteins indices depends on the behavior of the individual and changes in his psycho-emotional state, while a prolonged increase in the levels of catecholamines and cortisol in peripheral blood causes the development of psychosomatic pathology. It is proved that under the influence of complex action of risk factors there are significant changes in the psycho-emotional state that cause hypertension. This is confirmed by the presence of the highest level of reactive anxiety in patients with hypertension of the 1st stage on the background of the lowest personal anxiety which is the basis for the occurrence of the disease. With the progression of hypertension there are more profound changes in the personality of the patient, which is accompanied by the accumulation of personal anxiety, which can lead to a depressive state of neurotic genesis, which we observed with its complication. On the basis of a comprehensive study, the effect of stress on the occurrence of a syndrome of psychoemotional stress is shown, which leads to a steady increase in blood pressure - hypertension, and with its subsequent action complicates its course.
 Bangladesh Journal of Medical Science Vol.19(4) 2020 p.722-729

Hyperuricemia Predicts Residual Diuresis Decline in Peritoneal Dialysis Patients

“…Not surprisingly, we found that hyperuricemia was more commonly diagnosed compared with other CKD causes in the PD patients with diabetes. Diabetes, as well as hypertension, has been recognized as a risk of GFR decline in CKD patients [13][14][15]20,22]. In agreement with our result, the presence of diabetes in predicting RRF decline in PD patients has been also demonstrated in previous studies [9,10,21].…”

“…The term RRF is generally understood to mean the residual capacity of the kidneys to eliminate water and uremic toxins [5,19]. It plays a significant role in maintaining fluid balance and, accordingly, blood pressure, phosphorus control, nutrition and toxins removal [4,5,19,20]. However, an optimal method for measuring RRF has not yet been established.…”

Психологічні Та Метаболічні Особливості Осіб Молодого Віку З Артеріальною Гіпертензією І Ступеня Та Дисгармонійною Жировою Компонентою Маси Тіла

“…-виявлено більш високі рівні вмісту лептину серед (81,1±5,4) % пацієнтів із пССР та достовірно (р<0,01) менш часто в групі з нССР -серед ( Проблема виявлення молодих людей з артеріальною гіпертензією на ранньому етапі, стратифікація серцево-судинного ризику, індивідуальний підбір адекватної терапії, а також упровадження профілактичних заходів щодо найпоширеніших факторів серцево-судинного ризику (ССР), у тому числі ожиріння на етапі первинної ланки медичної допомоги залишається дискутабельним та потребує подальшого вивчення [3,4,7].…”

Role of Impaired Oxalate Homeostasis in Cardiovascular Disease in Patients With End-Stage Renal Disease: An Opinion Article

“…Loss of kidney function decreases renal oxalate clearance and increases plasma oxalic acid (POx) concentration, according to the progression of chronic kidney disease (CKD) stages (Robijn et al, 2011;Perinpam et al, 2017). The accumulation of oxalate may be associated with oxidative stress, inflammation (Khan, 2014;Ermer et al, 2016;Dominguez-Gutierrez et al, 2018;Korol et al, 2021) and a high risk of cardiovascular disease (CVD) (Liu et al, 2014;Fan X et al, 2017;Arafa et al, 2020;Demikhov et al, 2020) in patients with kidney stones. However, although impaired oxalate homeostasis is a well-known occurrence in patients with end-stage renal disease (ESRD), a high POx concentration has never been considered a trigger for oxidative stress, systemic inflammation, and CVD risk in these patients.…”