Association between distinct intratumoral and stromal tumor infiltrating immune cells and pathologic complete response (pCR) in different breast cancer subtypes after neoadjuvant chemotherapy (NAC).

González-Cortijo, Lucía; Murillo, Raquel; Acevedo, Agustín; Cuesta, Ricardo Sáinz de la; Hernandez-Cortes, Gines; Vega, Vicente Martínez de; García‐Linares, Susana; Perez-Carrion, R.; Gonzalez, F. Ferrer; Rodriguez-Marquez, Cristina; Henriquez, Alexandra; Cerro, Elia del; Díaz-Gavela, Ana Aurora; Maldonado, Antonio; Fuertes, Silvia; Yerro, Jose L. Martín del; Sanz, Igñacio; Hornedo, Javier

doi:10.1200/jco.2016.34.15_suppl.1033

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“…In 2014, the International TILs Working Group published a recommendation in order to unify the methods of assessment of TILs and explore their clinical relevance, which endorsed using stromal TILs for standard reporting [ 39 ]. More recent studies evaluating TILs in TNBC before/after NAT showed that both stromal and intra-tumoural TILs are predictive of pCR, though the presence of stromal TILs seemed to be more significant [ 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

Breast-Gynaecological & Immuno-Oncology International Cancer Conference (BGICC) Consensus and Recommendations for the Management of Triple-Negative Breast Cancer

Elghazaly

Rugo

Azim

et al. 2021

Cancers

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Background: The management of patients with triple-negative breast cancer (TNBC) is challenging with several controversies and unmet needs. During the 12th Breast-Gynaecological & Immuno-oncology International Cancer Conference (BGICC) Egypt, 2020, a panel of 35 breast cancer experts from 13 countries voted on consensus guidelines for the clinical management of TNBC. The consensus was subsequently updated based on the most recent data evolved lately. Methods: A consensus conference approach adapted from the American Society of Clinical Oncology (ASCO) was utilized. The panellists voted anonymously on each question, and a consensus was achieved when ≥75% of voters selected an answer. The final consensus was later circulated to the panellists for critical revision of important intellectual content. Results and conclusion: These recommendations represent the available clinical evidence and expert opinion when evidence is scarce. The percentage of the consensus votes, levels of evidence and grades of recommendation are presented for each statement. The consensus covered all the aspects of TNBC management starting from defining TNBC to the management of metastatic disease and highlighted the rapidly evolving landscape in this field. Consensus was reached in 70% of the statements (35/50). In addition, areas of warranted research were identified to guide future prospective clinical trials.

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Section: Discussionmentioning

confidence: 99%