Association Between Discrimination Stress and Suicidality in Preadolescent Children

Argabright, Stirling T.; Visoki, Elina; Moore, Tyler M.; Ryan, Dallas T.; DiDomenico, Grace E.; Njoroge, Wanjikũ; Taylor, Jerome; Gülöksüz, Sinan; Gur, Ruben C.; Gur, Raquel E.; Benton, Tami D.; Barzilay, Ran

doi:10.1016/j.jaac.2021.08.011

Cited by 30 publications

(17 citation statements)

References 50 publications

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“…This study provides an excellent opportunity to study how brain pathways explain the effects of social environment on STBs in AA and non-Latino White children. [73][74][75]…”

Section: Discussionmentioning

confidence: 99%

Perceived Discrimination and Suicidal Thoughts and Behaviors Among American African American and White Children

Assari

2021

Hosp Pract Res

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Background: Perceived discrimination (PD) is a risk factor of suicidal thoughts and behaviors (STB) for children, youth, and adults. However, it is unknown whether the association between PD and STB frequency differs between African American (AA) and Non-Hispanic White children. Objectives: In this study, we compared AA and non-Latino White children for the association between PD and STB frequency in a national sample of 9-10-year-old American children. Methods: This cross-sectional study used data from the Adolescent Brain Cognitive Development (ABCD) study, which included 7883 non-Latino White or AA children between the ages of 9 and 10. The predictor variable was frequency of PDs. Race was the moderator. The outcome variable was STB frequency, treated as a count variable, reflecting positive STB items endorsed over the life-course. Covariates included sex, age, marital status, household income, parental education, parental employment, trauma, and economic difficulties. Poisson regression was used for data analysis. Results: Of all the participants, 5994 were non-Latino Whites, and 1889 were AAs. Overall, PD frequency was positively associated with STB frequency. A statistically significant interaction was found between race and PD, suggesting that the association between PD and STB frequency is weaker in AA than non-Latino White children. Conclusion: The observed weaker association between PDs frequency and STB frequency in AA than non-Latino White children suggests that PD may be a less salient risk factor of STB frequency for AA than non-Latino White children. Researchers should explore factors other than PD for suicide prevention of AA children in the US.

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“…This study provides an excellent opportunity to study how brain pathways explain the effects of social environment on STBs in AA and non-Latino White children. [73][74][75]…”

Section: Discussionmentioning

confidence: 99%

Perceived Discrimination and Suicidal Thoughts and Behaviors Among American African American and White Children

Assari

2021

Hosp Pract Res

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“… 47 We combined suicidal ideation and attempts, consistent with previous analyses, because the proportion of suicide attempts was low and because we aimed to mitigate type I error risk caused by multiple testing. 48 , 49 , 50 , 51 In the main analyses, past and current suicidal ideation and attempts were collapsed into a single binary measure termed “suicidality.” In sensitivity analyses, we tested associations of exposures with suicidal ideation and suicide attempts separately. Because previous reports (including from the ABCD study) showed poor youth-caregiver agreement on suicidality, 52 , 53 we focused on youth reports in the main analyses.…”

Section: Methodsmentioning

confidence: 99%

“…Race and ethnicity data were self-reported and were collected owing to disparities in youth suicidality and specifically in the ABCD study. 49 To address confounding effects of other variables previously linked to childhood suicidality in the ABCD study, 48 , 49 , 51 , 53 we ran models covarying for family conflict, parental supervision, school environment, negative life events, and experiences of racial and ethnic discrimination. To address the confounding effect of comorbid (nonsuicidality) psychopathology, we included measures representing internal and external psychopathology derived from youth reports (Brief Problem Monitor 54 ) and parent reports (Child Behavioral Checklist 55 ), respectively.…”

Section: Methodsmentioning

confidence: 99%

Association of Cyberbullying Experiences and Perpetration With Suicidality in Early Adolescence

et al. 2022

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“…The study collects data on parental history of psychiatric conditions ( 7 ), including suicide attempt/death. Participants are evaluated annually for history of suicide attempts, and endorsement of suicide attempts in Black participants is significantly higher ( 8 ). Here, we aimed to evaluate the contribution of PRS-SA to explaining variance in self-reported suicide attempt by early adolescence and to determine the additive effect of this score over and above parental history of suicide attempt/death.…”

Section: Introductionmentioning

confidence: 99%

Genetic risk, parental history, and suicide attempts in a diverse sample of US adolescents

et al. 2022

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BackgroundAdolescent suicide is a major health problem in the US marked by a recent increase in risk of suicidal behavior among Black/African American youth. While genetic factors partly account for familial transmission of suicidal behavior, it is not clear whether polygenic risk scores of suicide attempt can contribute to suicide risk classification.ObjectivesTo evaluate the contribution of a polygenic risk score for suicide attempt (PRS-SA) in explaining variance in suicide attempt by early adolescence.MethodsWe studied N = 5,214 non-related youth of African and European genetic ancestry from the Adolescent Brain Cognitive Development (ABCD) Study (ages 8.9–13.8 years) who were evaluated between 2016 and 2021. Regression models tested associations between PRS-SA and parental history of suicide attempt/death with youth-reported suicide attempt. Covariates included age and sex.ResultsOver three waves of assessments, 182 youth (3.5%) reported a past suicide attempt, with Black youth reporting significantly more suicide attempts than their White counterparts (6.1 vs. 2.8%, p < 0.001). PRS-SA was associated with suicide attempt [odds ratio (OR) = 1.3, 95% confidence interval (CI) 1.1–1.5, p = 0.001]. Parental history of suicide attempt/death was also associated with youth suicide attempt (OR = 3.1, 95% CI, 2.0–4.7, p < 0.001). PRS-SA remained significantly associated with suicide attempt even when accounting for parental history (OR = 1.29, 95% CI = 1.1–1.5, p = 0.002). In European ancestry youth (n = 4,128), inclusion of PRS-SA in models containing parental history explained more variance in suicide attempt compared to models that included only parental history (ΔR2 = 0.7%, p = 0.009).ConclusionsFindings suggest that PRS-SA may be useful for youth suicide risk classification in addition to established risk factors.

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Association Between Discrimination Stress and Suicidality in Preadolescent Children

Cited by 30 publications

References 50 publications

Perceived Discrimination and Suicidal Thoughts and Behaviors Among American African American and White Children

Perceived Discrimination and Suicidal Thoughts and Behaviors Among American African American and White Children

Association of Cyberbullying Experiences and Perpetration With Suicidality in Early Adolescence

Genetic risk, parental history, and suicide attempts in a diverse sample of US adolescents

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