Association Between Different Measures of Blood Pressure and Coronary Artery Calcium in Postmenopausal Women

Allison, Matthew A.; Manson, Jo Ann E.; Langer, Róbert; Aragaki, Aaron K.; Smoller, Sylvia; Lewis, Cora E.; Thomas, Asha; Lawson, William; Cochrane, Barbara B.; Hsia, Judith; Hunt, Julie R.; Robinson, Jennifer G.

doi:10.1161/hypertensionaha.108.118315

Cited by 10 publications

(4 citation statements)

References 43 publications

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“…In addition, systolic blood pressure, high-density lipoproteins, fasting blood glucose, and eGFR were also found to be significantly associated with high CAC. Previous studies showed that high systolic blood pressure is associated with CAC, as well as with the risk of coronary and cardiovascular events [ 21 , 22 ]. Patients with subclinical atherosclerosis, as determined by CAC scores, reportedly have fewer high-density lipoprotein particles [ 23 ]; conversely, increasing levels of high-density lipoproteins were also associated with less CAC [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Association of Bone Mineral Density and Coronary Artery Calcification in Patients with Osteopenia and Osteoporosis

2020

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The aim of this study was to investigate the association between bone mineral density (BMD) and coronary artery calcification (CAC) in adults with osteopenia or osteoporosis. A retrospective medical review study was conducted in a regional hospital in southern Taiwan. Medical records of patients who underwent both a coronary computed tomography scan and a BMD measurement were identified. Multinomial logistic regression analyses were used to assess the association between BMD and CAC levels in patients with osteopenia or osteoporosis. Of the 246 patients, 119 were female and 42.3% had CAC. For patients with osteopenia, after adjusting for the significant factors of CAC, no significant association was observed between BMD with either moderate CAC (0 < CAC score ≤ 100) or high CAC (CAC score > 100). However, in patients with osteoporosis, after adjusting for the significant factors of CAC, BMD in the lumbar spine was inversely associated with moderate CAC (odds ratio = 0.38, p = 0.035). In conclusion, a lower BMD in the lumbar spine was associated with an increased risk of moderate CAC in patients with osteoporosis. It is crucial to take action to maintain bone health, particularly in those who already have osteoporosis, to reduce the risk of developing CAC and its associated morbidity and mortality.

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Section: Discussionmentioning

confidence: 99%

Association of Bone Mineral Density and Coronary Artery Calcification in Patients with Osteopenia and Osteoporosis

2020

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“…Prior to our study, there has been only limited information on the presence of atherosclerotic calcification in non-coronary vascular beds 11. A previous study demonstrated that the detection of extra-coronary atherosclerosis, potentially helps to indentify individuals more likely to develop new calcified coronary disease 12.…”

Section: Discussionmentioning

confidence: 99%

Blood Pressure and Vascular Calcification

et al. 2010

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Abstract-The aim of this study was to determine the associations between the presence and extent of calcified atherosclerosis in multiple vascular beds and systolic blood pressure, diastolic blood pressure, pulse pressure, mean arterial pressure, isolated systolic hypertension, and hypertension. A total of 9510 patients (42.5% women) underwent electron beam computed tomography scanning as part of a routine health maintenance screening. At the same visit, blood pressure was measured with the participant in the seated position using a mercury sphygmomanometer. Mean age was 58Ϯ11.4 years, and body mass index was 27.1Ϯ4.5. The prevalences of any calcification in the carotids, coronaries, subclavians, thoracic aorta, abdominal aorta, and iliacs were 31.9%, 57.2%, 31.7%, 37.0%, 54.3%, and 48.8%, respectively. In separate multivariable logistic models containing traditional cardiovascular disease risk factors, pulse pressure and systolic blood pressure were significantly associated with the presence of calcification in all of the vascular beds except the iliacs and subclavians, respectively, with pulse pressure having stronger magnitudes of the associations for most of the vascular beds. Age-stratified analyses indicated that these associations were stronger in those Ͼ60 years of age compared with subjects Ͻ60 years of age, and sex-stratified analyses demonstrated that men had a greater association compared with women. Also, the magnitudes of the associations for isolated systolic hypertension were, in general, larger than those for hypertension. Pulse pressure and isolated systolic hypertension are robust and important correlates for calcified atherosclerosis in different vascular beds. Isolated systolic hypertension may be clinically relevant in diagnosing or preventing calcified atherosclerosis. (Hypertension. 2010;55:990-997.)Key Words: pulse pressure Ⅲ isolated systolic hypertension Ⅲ systolic blood pressure Ⅲ calcification Ⅲ atherosclerosis Ⅲ hypertension Ⅲ vascular beds E pidemiological studies suggest that elevated blood pressure (BP) is an independent and strong predictor of cardiovascular disease (CVD). 1 Controversy exists as to which BP measure is the best predictor of CVD events. Recent data suggest that aortic stiffness is an independent predictor of future heart disease in older individuals. 2 Increases in aortic stiffness are believed to be closely linked to increases in pulse pressure, thereby placing a higher afterload on the left ventricle. 3 Thus, pulse pressure (PP) may be relevant in the pathophysiology of coronary heart disease. 4 Calcium is deposited early in the formation of the atherosclerotic plaque and can be used as a marker of the atherosclerotic process. 5 The use of electron beam computed tomography affords the opportunity to noninvasively construct cross-sectional images of arteries to detect the presence and extent of calcium attributed to atherosclerosis in different vascular beds. 6 The coronary calcium score is significantly predictive of future cardiac events. 7 There are many risk...

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“…Low DBP is associated with carotid stenosis in subjects with isolated systolic hypertension 9 and with coronary artery calcium in postmenopausal women. 31 Several pathophysiological mechanisms have been suggested to explain the J-shaped phenomenon. 30 Low DBP may reflect the presence of a clinical or subclinical comorbid condition (especially heart disease or cancer).…”

Section: Discussionmentioning

confidence: 99%