2009
DOI: 10.1038/ajh.2009.151
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Pulse Pressure, Prehypertension, and Mortality: The San Antonio Heart Study

Abstract: Prehypertension increases mortality risk (all-cause and cardiovascular) in individuals who are free of diabetes and cardiovascular disease. Nevertheless, this relationship is not evident in individuals with narrow pulse pressure. Therefore, pulse pressure may be a relevant measure of blood pressure for the definition of normal blood pressure.

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Cited by 30 publications
(29 citation statements)
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“…Pulse pressure (PP=SBP-DBP) is an emerging independent risk factor for cardiovascular morbidity (7), and widening of pulse pressure has in the past been attributed to either increased cardiac contractility or diminished vascular compliance (38). Our data indicate that pulse pressure is already increased in prehypertension, and that the change can be attributed to both elevated contractility and diminished vascular compliance, even at this early stage.…”
Section: Discussionmentioning
confidence: 99%
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“…Pulse pressure (PP=SBP-DBP) is an emerging independent risk factor for cardiovascular morbidity (7), and widening of pulse pressure has in the past been attributed to either increased cardiac contractility or diminished vascular compliance (38). Our data indicate that pulse pressure is already increased in prehypertension, and that the change can be attributed to both elevated contractility and diminished vascular compliance, even at this early stage.…”
Section: Discussionmentioning
confidence: 99%
“…The emerging cardiovascular risk factor (7) PP (=SBP-DBP) was already elevated (by ~17.5%) even in prehypertension. Why did this occur?…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…15,16 The prevalence of prehypertension in this Hungarian sample is also considerably higher compared to previously reported prevalence data in non-European countries such as the US and Jamaica, i.e., ~30% of the adult population (both countries). [17][18][19][20] While the association of hypertension with premature CVD morbidity and mortality has been well established, 21 it is now also widely accepted that any increase in BP values represents increased CVD risk, even at BP levels below the ones that are currently used to define hypertension, i.e., SBP ≥140 mm Hg and DBP ≥90 mm Hg. [21][22][23] Regarding the risk of stroke in particular, no lower cut-point of BP levels has been described; the risk is increasing continuously beginning with SBP as low as 115 mm Hg and DBP of 70 mm Hg.…”
Section: Predictors Of Hypertensionmentioning
confidence: 99%
“…In the United States alone, up to ~41.9 million men and ~27.8 million women may exhibit prehypertension (2). Prehypertension tends to progress to hypertension over a relatively short time course, and is a risk factor for development of microalbuminuria and cardiovascular disease, with consequently increased mortality (3)(4)(5)(6)(7). However, the origins and pathogenesis of the syndrome are not yet well understood.…”
Section: Introductionmentioning
confidence: 99%