Association between Dietary Vitamin A Intake and the Risk of Glioma: Evidence from a Meta-analysis

Lv, Wen; Xian, Zhang; Xu, Lei; Han, Weidong

doi:10.3390/nu7115438

Cited by 37 publications

(22 citation statements)

References 24 publications

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“…Furthermore, conflicting findings might be explained by different methods used to measure dietary TAC, different study designs, different tools for assessing dietary intakes (FFQ, food record or dietary history) and considering different grades of this type of brain tumor. We found an inverse association with glioma for high intake of vitamin C, vitamin B6 and β-carotene which is consistent with findings from two recent meta-analyses [31,32]. Pervious studies have shown that dietary antioxidants were effective in decreasing of lipid peroxidation level by scavenging free radicals generated in the brain tissues which caused oxidative DNA damage.…”

Section: Discussionsupporting

confidence: 91%

“…BMI was calculated as weight (kg) divided by height (m 2 ). We considered farmers as having a high-risk occupation for glioma on the basis of previous publications (32). Individuals who lived in places near the electromagnetic fields and cell phone and broadcast antennas in the last 10 years were defined as living in high-risk areas [30].…”

Section: Assessment Of Other Variablesmentioning

confidence: 99%

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The association between dietary total antioxidant capacity and glioma among Iranian adults

Heydari¹,

Shayanfar²,

Sharifi³

et al. 2020

Preprint

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Background: Dietary total antioxidant capacity (TAC) has been investigated in relation to different types of cancer. However, data on the link between dietary TAC and glioma are scarce and conflicting. We assessed the relation between dietary TAC and risk of glioma among Iranian adults. Methods: This investigation was a hospital-based case-control study that was done in Tehran between November 2009 and September 2011. Cases were individuals with pathologically confirmed glioma that were diagnosed during the last month (n=128). Controls were individuals, aged between 20 and 75 years, who were hospitalized or were outpatients referred to other wards of the same hospitals (n=256). Usual dietary intakes of participants during the preceding year were examined using a food frequency questionnaire. Data on dietary TAC from foods was gathered from published databases that provided the antioxidant capacity for each food item, measured by ferric reducing antioxidant power (FRAP). Results: Mean age of study participants in case and control groups was 43.4 and 42.7 y, respectively. Compared with participants in the lowest quartile, those in the highest quartile of dietary TAC had a lower odds of glioma (OR: 0.28, 95% CI: 0.15-0.45). This association was strengthened when potential confounders were taken into account (OR: 0.13; 95% CI: 0.05-0.35). Such inverse association was also seen for men (OR: 0.05, 95% CI: 0.01-0.19), but not for women. Furthermore, significant inverse associations were seen between dietary intakes of vitamin C (OR for Q4 vs. Q1: 0.14, 95% CI: 0.05-0.36; P-trend<0.01), vitamin B6 (OR for Q4 vs. Q1: 0.35, 95% CI: 0.13-0.97; P-trend=0.02) and β-carotene (OR for Q3 vs. Q1: 0.43, 95% CI: 0.19-0.98; P-trend=0.57) and glioma, after controlling for potential covariates. Conclusion: We found that dietary TAC as well as dietary intake of vitamin C, vitamin B6 and β-carotene was inversely associated with odds of glioma in Iranian adults.

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Section: Discussionsupporting

confidence: 91%

Section: Assessment Of Other Variablesmentioning

confidence: 99%

The association between dietary total antioxidant capacity and glioma among Iranian adults

Heydari¹,

Shayanfar²,

Sharifi³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Lifestyles and diet has been found to be associated with many types of cancer. As for brain cancer, N-nitroso compounds (NOC), contained in processed meat, has been long noticed to be associated with higher risk of brain tumor [4], recent meta-analysis also indicated that processed meat consumption was associated with higher risk of brain tumor [5], while intakes of vegetables, fruits [6, 7] and vitamin A [8] might reduce its risk.…”

Section: Introductionmentioning

confidence: 99%

Fish intake and the risk of brain tumor: a meta-analysis with systematic review

Lian

Wang

Xing

et al. 2017

Nutr J

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BackgroundFish, rich in ω-3 polyunsaturated fatty acids, has been found to be associated with lower risk of several types of cancer risk, and beneficial for brain development. However, the association between fish intake and brain tumor risk is still inconsistent. Therefore, we conducted a meta-analysis to clarify the association.MethodsRelevant studies were identified from PubMed and EMBASE databases. The pooled relative risks were obtained by the fixed-effects model when no substantial heterogeneity was observed. Otherwise, the random-effects model was employed. Subgroup and publication bias analyses were also performed.ResultsNine observational studies were included in the meta-analysis. The pooled relative risk of brain cancer for the highest vs. lowest category of fish intake was 0.83 (95% confidence interval [CI]: 0.70–0.99). No significant heterogeneity was detected. Dose-response analysis showed that the RR per 100 g/day increase in fish intake was 0.95 (95% CI: 0.91–0.98). The results remained unchanged in subgroup and sensitivity analyses.ConclusionsThe results of our meta-analysis suggest that fish intake might be associated with lower risk of brain cancer risk. The finding should be further confirmed by future cohort studies with validated questionnaires and strict control of confounders.Electronic supplementary materialThe online version of this article (doi:10.1186/s12937-016-0223-4) contains supplementary material, which is available to authorized users.

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“…Therefore, beside the IL-13 gene rs20541 polymorphism, other genetic, environmental, or lifestyle factors and underlying diseases may also play a role in its pathogenesis. Previous meta-analyses have demonstrated that the ERCC1 gene [33], the CDKN2A/B gene [33], diabetes mellitus [34], vitamin A intake [35], and some other factors have significant associations with glioma susceptibility. Moreover, some factors, including differences in the subjects' characteristics, ethnicity, and recruitment criteria, and in sample size may lead to the inconsistency.…”

Section: Discussionmentioning

confidence: 99%

Association between <b><i>IL-13</i></b> Gene rs20541 Polymorphism and Glioma Susceptibility: A Meta-Analysis

Yang

Yuan²,

Zhang³

et al. 2018

Oncol Res Treat

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Objective: We performed a meta-analysis to estimate the association between IL-13 gene rs20541 (R130Q) polymorphism and the susceptibility of glioma. Patients and Methods: Potentially eligible studies published before February 1, 2016 were searched in 4 databases including PubMed, EMBASE, EBSCO, and Ovid. Odds ratios (ORs) and their corresponding 95% confidence intervals (95% CIs) were used to estimate the strength of relationship between the IL-13 gene rs20541 polymorphism and glioma susceptibility. Stata 11.0 software was used to perform the present meta-analysis. Results: In total, 10 case-control studies with 13 datasets including 3,123 cases and 5,390 controls were identified. A significant increase in glioma susceptibility was found in the dominant model (AA + AG vs. GG: OR = 1.14, 95% CI 1.01-1.29; P = 0.031). Significantly decreasing glioma susceptibility was found for Asians in the heterozygote comparison (AG vs. GG: OR = 0.74, 95% CI 0.55-0.99; P = 0.042) and the allele contrast genetic model (A vs. G: OR = 0.67, 95% CI 0.47-0.96; P = 0.028). By contrast, in Caucasians, a significant increase in glioma susceptibility was found in the dominant model (AA + AG vs. GG: OR = 1.25, 95% CI 1.11-1.41; P = 0.000). Conclusion: There may be a weak association between the IL-13 gene rs20541 polymorphism and glioma susceptibility, and the associations may be different between ethnicities.

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Association between Dietary Vitamin A Intake and the Risk of Glioma: Evidence from a Meta-analysis

Cited by 37 publications

References 24 publications

The association between dietary total antioxidant capacity and glioma among Iranian adults

The association between dietary total antioxidant capacity and glioma among Iranian adults

Fish intake and the risk of brain tumor: a meta-analysis with systematic review

Association between <b><i>IL-13</i></b> Gene rs20541 Polymorphism and Glioma Susceptibility: A Meta-Analysis

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