Association between dietary intake of polyunsaturated fatty acid and prevalence of hypertension in U.S. adults: A cross-sectional study using data from NHANES 2009–2016

Ni, Senmiao; Zhong, Zihang; Wei, Junting; Zhou, Jiawei; Cai, Lixin; Yang, Min; Xun, Pengcheng; Zhao, Yang; Yu, Hao; Bai, Jianling

doi:10.1038/s41440-021-00849-1

Cited by 7 publications

(8 citation statements)

References 35 publications

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“…Studies support the positive role of nuts in blood pressure regulation, with higher nut intake linked to lower hypertension prevalence 55 . The abundance of polyunsaturated fatty acids in nuts, including omega‐3, omega‐6 and α‐linolenic acid, is considered key to these benefits 56 . Another study demonstrated the benefits of including nut‐derived minerals in daily diets in reducing hypertension risk 57 .…”

Section: Discussionmentioning

confidence: 99%

“…55 The abundance of polyunsaturated fatty acids in nuts, including omega-3, omega-6 and α-linolenic acid, is considered key to these benefits. 56 Another study demonstrated the benefits of including nut-derived minerals in daily diets in reducing hypertension risk. 57 Therefore, we hypothesise that the beneficial effect of nut consumption on hypertension prevention carries significant implications for further reducing frailty.…”

Section: Discussionmentioning

confidence: 99%

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Association between nut consumption and frailty in the elderly: a large sample cross‐sectional study

Yang

Zhang

Yuan

et al. 2023

J Human Nutrition Diet

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BackgroundLimited literature has addressed the impact of nut consumption in mitigating frailty. This study aimed to investigate the association between nut consumption and frailty among Americans aged above 60 years, employing two 24‐h dietary recalls for analysis.MethodsThe data sets of the National Health and Nutrition Examination Survey (NHANES) (2003–2018) and the Food Patterns Equivalents Database were utilised for a weighted multiple logistic regression model to evaluate the association between nut consumption and frailty in elderly adults. Furthermore, a restricted cubic spline model was employed to investigate the nonlinear relationship between nut intake and frailty. Besides, stratified and interaction analyses were conducted to explore the sensitivity of nut consumption in reducing the risk of frailty in diverse subgroups.ResultsThe research study comprised 10,033 individuals aged 60 years or above, of whom 3591 were classified as frailty and 5302 consumed nuts. In the multivariate logistic regression analysis that adjusted for covariates, the weighted multivariate adjusted odds ratios demonstrated that the prevalence of frailty was lower in the nut intake group than in nonconsumers. The stratified analysis indicated that nearly all subgroups who consumed nuts had a significantly lower risk of frailty compared to nonconsumers, and an interaction was observed between nut intake and nonhypertensive populations. The optimal threshold for nut intake to decrease the risk of frailty was identified as 1.02 ounces.ConclusionsThe study concluded that nut consumption has a constructive impact on averting frailty in elderly adults, particularly in nonhypertensive individuals. Nut intake of ~1.02 ounces per day is advantageous in improving the quality of life in elderly adults.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association between nut consumption and frailty in the elderly: a large sample cross‐sectional study

Yang

Zhang

Yuan

et al. 2023

J Human Nutrition Diet

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“…Demographic information was collected by questionnaire, including age (20–44, 45–64, 65, and older), gender, race (non-Hispanic white, non-Hispanic black, Hispanic, and others), smoking status (never smoked [less than 100 cigarettes in a lifetime], formerly smoked [smoked more than 100 cigarettes in lifetime, now not smoking at all], and currently smoking [smoked more than 100 cigarettes in lifetime, some days, or every day]), education (less than high school, high school graduate/general education, some college, or above), and family income to poverty ratio (less than 1.30, 1.30 to <3.00, 3.00 to <5.00, 5.00 and above) represents the ratio of family income to the federal poverty threshold, adjusting for household size. A higher ratio indicates higher levels of income, marital status (marriage, divorce, unmarried), and drinking status (current heavy drinker [women drink ≥ 3 drinks per day/men drink ≥ 4 drinks per day/binge drinking 5 days or more]; current moderate drinkers [women drink ≥ 2 drinks per day/men drink ≥ 3 drinks per day/binge drinking ≥ 2 days per month]; current light alcohol users [not the above two categories] ( 6 ); and no alcohol consumption). Physical activity (using total Mets for the week: <600, Mets, min/week, when exercise ≥ 600, Mets, min/week.…”

Section: Methodsmentioning

confidence: 99%

“…The protective effect of nutrients on hypertension is not negligible ( 4 , 5 ). Among them, saturated fatty acids (SFAs), polyunsaturated fatty acids, and monounsaturated fatty acids are closely related to hypertension ( 6 , 7 ). Common sources of SFA are coconut oil, rice bran oil, red meat, high-fat dairy products, and human breast milk.…”

Section: Introductionmentioning

confidence: 99%

Association of dietary intake of saturated fatty acids with hypertension: 1999–2018 National Health and Nutrition Examination Survey

Gou

Qin

et al. 2022

Front. Nutr.

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ObjectiveThis study aimed to assess the relationship between the dietary intake of saturated fatty acids (SFAs) and its subtypes (C4:0, C6:0, C8:0, C10:0, C12:0, C14:0, C16:0, and C18:0) and hypertension.Design, participants, and methodsAdults aged 20 years and older based used the U.S. Health and Nutrition Survey (1999–2018) were used as participants. Two averages of 24 h dietary recall data were obtained for weight-adjusted continuous cross-sectional analysis. Two 24-h recall interview data means were obtained for weight-adjusted continuous cross-sectional analysis. A logistic regression model was used to estimate the weighted odds ratio (OR) and its 95% confidence interval (CI) for hypertension.ResultsThe study included 7,222 respondents over 20 years of age with a hypertension prevalence of 23.2% and a significant difference in the dietary intake of carbohydrates among patients with hypertension. Dietary intake of nutrients was more in men than in women with hypertension. After adjusting for confounders, adjusting for nutrients, and reducing covariance among nutrients, the OR (95% CI) for women’s dietary intake of SFAs, C14:0, C16:0, C18:0 fourth quartile, and C14:0 third quartile were 0.57 (0.34, 0.95), 0.57 (0.34, 0.95), 0.57 (0.34, 0.95), 0.57 (0.34, 0.95), and 0.57 (0.34, 0.95), respectively, which may be a risk factor for hypertension. In older (≥65, years) respondents, the OR (95% CI) for dietary intake of SFAs, C4:0, C14:0, C16:0 fourth quartile, and C12:0 third quartile were 0.42 (0.21, 0.86), 0.46 (0.22, 0.95), 0.39 (0.18, 0.85), 0.38 (0.17, 0.84), and 0.45 (0.20, 0.99), respectively, which may be a protective factor for hypertension.ConclusionThe study was based on the American Health and Nutrition Examination Survey, and a strong correlation was found between dietary intake of SFAs, C14:0, C16:0, and C18:0 and hypertension in women (dietary intake of SFAs, C4:0, C12:0, C14:0, and C16:0) and middle-aged and older adults (dietary intake of SFAs, C4:0, C12:0, C14:0, and C16:0). In addition, dietary nutrient intake should be carefully selected for the rational prevention of hypertension.

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“…8,9 RvE1 promotes inflammation resolution by activating a G protein-coupled receptor, ChemR23 (chemerin receptor 23), and exerts a protective effect on multiple cardiovascular diseases. 8,9 Clinical studies and systematic reviews have shown that the intake of Ω-3 PUFAs is closely associated with decreased blood pressure in different hypertensive populations, 10,11 suggesting that SPMs, as the metabolites of PUFAs, may have a stronger biological effect in the treatment of hypertension. Liu et al 12 suggested that RvE1 could suppress pulmonary arterial smooth muscle cell proliferation and mitigate pulmonary hypertension by inhibiting wnt7a/β-catenin signaling.…”

Section: Clinical/pathophysiological Implications?mentioning

confidence: 99%

Resolvin E1/ChemR23 Protects Against Hypertension and Vascular Remodeling in Angiotensin II–Induced Hypertensive Mice

Zhang,

Yin,

et al. 2023

Hypertension

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Background: Inflammation plays a critical role in the development of hypertension and vascular remodeling. RvE1 (resolvin E1), as one of the specialized proresolving lipid mediators, promotes inflammation resolution by binding with a G protein-coupled receptor, ChemR23 (chemerin receptor 23). However, whether RvE1/ChemR23 regulates hypertension and vascular remodeling is unknown. Methods and Results: Hypertension in mice was induced by Ang (angiotensin) II infusion (750 ng/kg per minute), and RvE1 (2 µg/kg per day) was administered through intraperitoneal injection. Loss of ChemR23 was achieved by mice receiving intravenous injection of adeno-associated virus 9-encoding shRNA against ChemR23. We found that aortic ChemR23 expression was increased in Ang II–induced hypertensive mice and that ChemR23 was mainly expressed on vascular smooth muscle cells (VSMCs). RvE1 lowered blood pressure, reduced aortic media thickness, attenuated aortic fibrosis, and mitigated VSMC phenotypic transformation and proliferation in hypertensive mice, which were all reversed by the knockdown of ChemR23. Moreover, RvE1 reduced the aortic infiltration of macrophages and T cells, which was also reversed by ChemR23 knockdown. RvE1 inhibited Ccl5 expression in VSMCs via the AMPKα (AMP-activated protein kinase α)/Nrf2 (nuclear factor E2-related factor 2)/canonical NF-κB (nuclear factor κB) pathway, thereby reducing the infiltration of macrophages and T cells. The AMPKα/Nrf2 pathway also mediated the effects of RvE1 on VSMC phenotypic transformation and proliferation. In patients with hypertension, the serum levels of RvE1 and other eicosapentaenoic acid-derived metabolites were significantly decreased. Conclusions: RvE1/ChemR23 ameliorated hypertension and vascular remodeling by activating AMPKα/Nrf2 signaling, which mediated immune cell infiltration by inhibiting the canonical NF-κB/Ccl5 pathway, and regulated VSMC proliferation and phenotypic transformation. RvE1/ChemR23 may be a potential therapeutic target for hypertension.

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Association between dietary intake of polyunsaturated fatty acid and prevalence of hypertension in U.S. adults: A cross-sectional study using data from NHANES 2009–2016

Cited by 7 publications

References 35 publications

Association between nut consumption and frailty in the elderly: a large sample cross‐sectional study

Association between nut consumption and frailty in the elderly: a large sample cross‐sectional study

Association of dietary intake of saturated fatty acids with hypertension: 1999–2018 National Health and Nutrition Examination Survey

Resolvin E1/ChemR23 Protects Against Hypertension and Vascular Remodeling in Angiotensin II–Induced Hypertensive Mice

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