Association Between Dietary Inflammatory Index and S-Klotho Plasma Levels in Middle-Aged and Elderly People

Ma, Teng-Chi; Zhou, Jing; Wang, Chenxi; Fang, Min; Gao, Feng

doi:10.3389/fnut.2022.853332

Cited by 9 publications

(7 citation statements)

References 32 publications

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“…Although these dietary quality measures are not entirely consistent, previous studies have demonstrated similar associations between different dietary qualities and S-Klotho. For example, both Chi-Chen and our previous NHANES studies imply that an inflammatory diet may lower S-Klotho levels ( 28 , 29 ). Shou-En found a positive association between Mediterranean adherence diet score (MDS) and S-Klotho levels based on NHANES.…”

Section: Discussionmentioning

confidence: 83%

Associations between the Healthy Eating Index-2015 and S-Klotho plasma levels: A cross-sectional analysis in middle-to-older aged adults

Zhou

Wang

et al. 2023

Front. Nutr.

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Background and aimThe Healthy Eating Index (HEI) is a dietary index developed by the United States Department of Agriculture (USDA) to determine whether a diet adheres to US dietary guidelines. Soluble Klotho (S-Klotho) is a protein with essential anti-aging properties. However, whether HEI is linked to S-Klotho plasma levels is still debatable. This study aimed to assess the association between HEI-2015 and S-Klotho in middle-to-older aged adults in the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2016.MethodsThe study included 8456 middle-to-older aged (40–79 years old) participants. Multivariate regression models were used to estimate the correlation between HEI-2015 and S-Klotho concentrations. General additive models and two-piece-wise regression models were used to investigate the possible non-linear relationships between HEI-2015 and S-Klotho concentrations. Moreover, a stratified analysis of potential influencing factors was performed.ResultsA positive correlation was observed between HEI-2015 and S-Klotho plasma levels (β = 0.74, 95% CI: 0.21, 1.27, P = 0.0067). According to the two-piece-wise regression, the turning point of HEI-2015 was 45.15. When the range of HEI-2015 was from 0 to 45.15, the relationship between HEI and S-Klotho was insignificant (β = −0.87, 95% CI: −2.47, 0.73, P = 0.2858). However, when the range of HEI-2015 was from 45.15 to 100, HEI-2015 increased by 1 unit, the S-Klotho increased by 1.30 pg/ml (β = 1.30, 95% CI: 0.55, 2.05, P = 0.0007), suggesting a dose-response relationship. Furthermore, the stratified analysis showed that the association between HEI-2015 and S-Klotho concentrations was more significant in people with normal body mass index (P-interaction = 0.0161).ConclusionThere is a dose-response relationship between the HEI-2015 and S-Klotho in the middle-to-older aged adults. This relationship suggests that adherence to healthy dietary patterns may benefit the prevention of aging and health maintenance. The underlying mechanisms require further investigation.

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Section: Discussionmentioning

confidence: 83%

Associations between the Healthy Eating Index-2015 and S-Klotho plasma levels: A cross-sectional analysis in middle-to-older aged adults

Zhou

Wang

et al. 2023

Front. Nutr.

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“…As it is widely acknowledged, there exists an anti-aging protein in plasma, soluble Klotho (S-Klotho). A research had indicated a negative association between S-Klotho and pro-inflammatory food patterns evaluated based on DII in people over 40 years old ( 26 ). Furthermore, these middle-aged and older people with high DII scores also had an increased likelihood of suffering from low HDL cholesterol, hyperglycemia, and metabolic syndrome ( 27 ).…”

Section: Discussionmentioning

confidence: 99%

Association between dietary inflammatory index and chronic kidney disease in middle-aged and elderly populations

Guo,

Lei,

Liu

et al. 2024

Front. Nutr.

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BackgroundA link between food-induced inflammation and common chronic diseases has been identified in studies. However, there was uncertainty about the influence of dietary inflammatory potential on the risk of chronic kidney disease (CKD) among middle-aged and older groups. Our research aimed to examine the connection between dietary inflammatory index (DII) to CKD in people aged 40 years and older.MethodsThis study comprised ten cycles of the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018. Linear associations of DII with CKD, low-eGFR, and albuminuria were examined using multiple logistic regression, whereas non-linear associations were assessed by smoothed curve fitting. Besides, we conducted subgroup analyses and interaction tests.ResultsOf the 23,175 middle-aged and older individuals, a total of 5,847 suffered from CKD, making up 25.23% of all participants. After adjustment for all covariates, we found that increased DII scores were positive with an increased hazard of CKD (OR = 1.08, 95% CI: 1.05, 1.10, p < 0.0001), and the same was shown between DII and low-eGFR (OR = 1.16, 95% CI: 1.13, 1.19, p < 0.0001). After further converting DII into categorical variables, the above relationship still existed. These relations were consistent in different ages, genders, BMI, whether smoking, whether suffering from hypertension, and whether suffering from diabetes, with no significant stratification differences (all P for interaction >0.05). Surprisingly, we did not find a statistically significant correlation of DII to albuminuria after complete adjustment for covariates (OR = 1.02, 95% CI: 1.00, 1.05, p = 0.0742). Even when DII was considered as a categorical variable, this relation was still not statistically significant. Furthermore, we found an association in the shape of a U between DII and low-eGFR in the fully adjusted model, with a turning point at a DII of 1.6.ConclusionOur findings indicated that middle-aged and older persons with greater levels of DII had a significantly higher risk of CKD.

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“…Additionally, Ma et al. found that chronic inflammation, caused by a pro-inflammatory diet pattern, can reduce serum klotho levels ( 37 ). Thus, as a characteristic of the obese state, the excessive proinflammatory products, mainly from adipose tissue, may in turn deplete the klotho protein in the serum, reducing its concentration.…”

Section: Discussionmentioning

confidence: 99%

A cross-sectional analysis of association between visceral adiposity index and serum anti-aging protein Klotho in adults

et al. 2023

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BackgroundThe visceral adiposity index (VAI) is regarded as a reliable indicator to assess body fat distribution and dysfunction. Klotho protein is a hormone with anti-aging biological functions. However, the relationship between them has not been researched.ObjectsThis study aimed to evaluate the association between VAI and serum anti-aging protein klotho in American adults.MethodsA cross-sectional study of participants was conducted based on the National Health and Nutrition Examination Surveys (NHANES) 2007–2016. Visceral adiposity was determined using the VAI score, while the klotho protein concentration was measured by ELISA kit. After adjusting some possible confounding variables, multivariate regression model was conducted to estimate the relationship between VAI and klotho protein. Furthermore, the smooth curve fitting and the segmented regression model were applied to examine the threshold effect and to calculate the inflection point.ResultIn total, 6 252 adults were eligible, with a mean VAI of 2.04 ± 0.03 and a mean klotho protein concentration of 848.79 ± 6.98 pg/ml. Multivariate regression analysis indicated that serum klotho protein concentration was lower in participants with high VAI score. When VAI was divided into quartiles, participants in the fourth quartiles of higher VAI had lower klotho protein levels (Q4: -32.25 pg/ml) than participants in the lowest quartile (Q1) after full adjustment (P < 0.05). Segmented regression suggested that the turning point value of VAI was 3.21. A 1-unit increase in VAI was significantly associated with lower klotho protein levels by -18.61 pg/ml (95% CI: -28.87, -8.35; P < 0.05) when VAI ranged from 0.29 to 3.21(accounting for 83.7% of the participants), however, the association was not significant when VAI ranged from 3.21 to 11.81 (P = 0.77).ConclusionThere was a nonlinear correlation between VAI score and the serum anti-aging protein klotho concentrations, showing a saturation effect. When VAI was less than 3.21, they were negatively correlated, and when VAI was greater than 3.21, they had no obvious correlation.

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Association Between Dietary Inflammatory Index and S-Klotho Plasma Levels in Middle-Aged and Elderly People

Cited by 9 publications

References 32 publications

Associations between the Healthy Eating Index-2015 and S-Klotho plasma levels: A cross-sectional analysis in middle-to-older aged adults

Associations between the Healthy Eating Index-2015 and S-Klotho plasma levels: A cross-sectional analysis in middle-to-older aged adults

Association between dietary inflammatory index and chronic kidney disease in middle-aged and elderly populations

A cross-sectional analysis of association between visceral adiposity index and serum anti-aging protein Klotho in adults

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