A cross-sectional analysis of association between visceral adiposity index and serum anti-aging protein Klotho in adults

Cui, Jianwei; Yang, Zhenzhen; Wang, Jiahao; Yin, Shan; Yan, Xiao; Bai, Yunjin; Wang, Jia

doi:10.3389/fendo.2023.1082504

Cited by 17 publications

(15 citation statements)

References 42 publications

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“…In a very elegant study, Cui et al 4 analyzed the association between the visceral adiposity index and serum levels of the anti-aging protein Klotho protein, using (United States) National Health and Nutrition Examination Survey data. The authors found that, among adults in the United States, there was a non-linear association, as well as a dose–response relationship, between serum Klotho levels and the visceral adiposity index.…”

Section: Discussionmentioning

confidence: 99%

“…The increased production of reactive oxidative species (ROS) and oxidative stress in adipose tissue can have various pathological manifestations 3 . It has also been demonstrated that an increase in visceral adiposity is associated with a decrease in serum Klotho protein levels; therefore, obesity induces a state of Klotho deficiency 4 . Obesity has been associated with acute kidney injury (AKI) in intensive care unit patients and in patients recovering from surgery 5 – 8 .…”

Section: Introductionmentioning

confidence: 99%

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Obesity aggravates acute kidney injury resulting from ischemia and reperfusion in mice

da Silva,

de Menezes,

Jacobina

et al. 2024

Sci Rep

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In critically ill patients, overweight and obesity are associated with acute respiratory distress syndrome and acute kidney injury (AKI). However, the effect of obesity on ischemia–reperfusion injury (IRI)-induced AKI is unknown. We hypothesized that obesity would aggravate renal IRI in mice. We fed mice a standard or high-fat diet for eight weeks. The mice were divided into four groups and submitted to sham surgery or IRI: obese, normal, normal + IRI, obese, and obese + IRI. All studies were performed 48 h after the procedures. Serum glucose, cholesterol, and creatinine clearance did not differ among the groups. Survival and urinary osmolality were lower in the obese + IRI group than in the normal + IRI group, whereas urinary neutrophil gelatinase-associated lipocalin levels, tubular injury scores, and caspase 3 expression were higher. Proliferating cell nuclear antigen expression was highest in the obese + IRI group, as were the levels of oxidative stress (urinary levels of thiobarbituric acid-reactive substances and renal heme oxygenase-1 protein expression), whereas renal Klotho protein expression was lowest in that group. Expression of glutathione peroxidase 4 and peroxiredoxin 6, proteins that induce lipid peroxidation, a hallmark of ferroptosis, was lower in the obese + IRI group. Notably, among the mice not induced to AKI, macrophage infiltration was greater in the obese group. In conclusion, greater oxidative stress and ferroptosis might aggravate IRI in obese individuals, and Klotho could be a therapeutic target in those with AKI.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Obesity aggravates acute kidney injury resulting from ischemia and reperfusion in mice

da Silva,

de Menezes,

Jacobina

et al. 2024

Sci Rep

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show abstract

“…Disease like insulin resistance and metabolic-associated fatty liver disease are thought to be significantly increased by high VAT mass [ 31 , 32 ]. The visceral adiposity index, an index for the evaluation of VAT, was found to be associated with aging in a study of 6,252 adults in the USA [ 33 ]. However, QCT is now thought to be a superior method for the assessment of VAT [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Assessment of whole-body and regional body fat using abdominal quantitative computed tomography in Chinese women and men

Mai,

Wu,

et al. 2024

Lipids Health Dis

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Background Being overweight or obese has become a serious public health concern, and accurate assessment of body composition is particularly important. More precise indicators of body fat composition include visceral adipose tissue (VAT) mass and total body fat percentage (TBF%). Study objectives included examining the relationships between abdominal fat mass, measured by quantitative computed tomography (QCT), and the whole-body and regional fat masses, measured by dual energy X-ray absorptiometry (DXA), as well as to derive equations for the prediction of TBF% using data obtained from multiple QCT slices. Methods Whole-body and regional fat percentage were quantified using DXA in Chinese males (n = 68) and females (n = 71) between the ages of 24 and 88. All the participants also underwent abdominal QCT measurement, and their VAT mass and visceral fat volume (VFV) were assessed using QCT and DXA, respectively. Results DXA-derived TBF% closely correlated with QCT abdominal fat percentage (r = 0.89–0.93 in men and 0.76–0.88 in women). Stepwise regression showed that single-slice QCT data were the best predictors of DXA-derived TBF%, DXA android fat percentage and DXA gynoid fat percentage. Cross-validation analysis showed that TBF% and android fat percentage could be accurately predicted using QCT data in both sexes. There were close correlations between QCT-derived and DXA-derived VFV (r = 0.97 in men and 0.93 in women). Conclusion Clinicians can assess the TBF% and android and gynoid fat percentages of Chinese women and men by analysing existing abdominal CT-derived data using the QCT technique.

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“…In a very elegant study, Cui et al (4) analyzed the association between the visceral adiposity index and serum levels of the anti-aging protein Klotho protein, using (United States) National Health and Nutrition Examination Survey data. The authors found that, among adults in the United States, there was a nonlinear association, as well as a dose-response relationship, between serum Klotho levels and the visceral adiposity index.…”

Section: Discussionmentioning

confidence: 99%

“…The increased production of reactive oxidative species (ROS) and oxidative stress in adipose tissue can have various pathological manifestations (3). It has also been demonstrated that an increase in visceral adiposity is associated with a decrease in serum Klotho protein levels; therefore, obesity induces a state of Klotho de ciency (4).…”

Section: Introductionmentioning

confidence: 99%

Obesity aggravates ischemia–reperfusion injury-induced acute kidney injury in mice

Silva

Menezes

Jacobina

et al. 2023

Preprint

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In critically ill patients, overweight and obesity are associated with acute respiratory distress syndrome and acute kidney injury (AKI). Although obesity is known to increase oxidative stress, worsen inflammation, and induce a state of Klotho deficiency, its effect on ischemia–reperfusion injury (IRI)-induced AKI is unknown. We hypothesized that obesity would aggravate renal IRI in mice. We fed mice a standard or high-fat diet for eight weeks. The mice were divided into four groups and submitted to sham surgery or IRI: obese, normal, normal + IRI, obese, and obese + IRI. All studies were performed 48 h after the procedures. Body weights were higher in the obese and obese + IRI groups than in the normal and normal + IRI groups, respectively. Serum glucose and cholesterol did not differ among the groups. Creatinine clearance also did not differ among the groups. Survival and urinary osmolality were lower in the obese + IRI group than in the normal + IRI group, whereas urinary neutrophil gelatinase-associated lipocalin levels, tubular injury scores, and caspase 3 expression were higher. In the obese + IRI group, the PCNA-positive cell counts were highest, as were the levels of oxidative stress (urinary levels of thiobarbituric acid-reactive substances and renal heme oxygenase-1 protein expression), and renal Klotho protein expression was lowest. Notably, macrophage infiltration was greater in the obese group mice than in the normal group mice, despite the fact that none of those mice were induced to AKI. In conclusion, greater oxidative stress might aggravate IRI in obese individuals, and Klotho could be a therapeutic target in those with AKI.

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A cross-sectional analysis of association between visceral adiposity index and serum anti-aging protein Klotho in adults

Cited by 17 publications

References 42 publications

Obesity aggravates acute kidney injury resulting from ischemia and reperfusion in mice

Obesity aggravates acute kidney injury resulting from ischemia and reperfusion in mice

Assessment of whole-body and regional body fat using abdominal quantitative computed tomography in Chinese women and men

Obesity aggravates ischemia–reperfusion injury-induced acute kidney injury in mice

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