Background: Currently, corona virus disease has imposed huge global burdens and psychological impacts. Although unpredicted stress from this outbreak resulted in disturbed sleep in general, its effect on sleep among pregnant women is not well explored yet. Thus, the main aim of this study was to explore quality of sleep among pregnant mothers amidst COVID-19 pandemic. Methods: Health facility-based cross-sectional study was carried out from April to May, 2020 among 228 pregnant women. Frequencies and related percentages were calculated for categorical variables, while continuous variables were computed by mean and standard deviation. Chi-square test was conducted and Pearson correlation coefficient (r) was calculated to assess relationship between variables. For statistical significance, p-value<.05 and 95% CI were considered. Results: For study subjects, the mean age was 30.79 (SD±7.57) and 57% of them had reported quality of sleep quality and mean sleep duration was 6.70 hours (SD±1.95). Among all participants, less than one-fifth (44, 19.3%) of them had reported very good subjective sleep quality. Perceived stress, depression and Anxiety have moderate to strong positive association with Pittsburgh Sleep Quality Index score (r=0.36, 0.37 and 0.57 respectively) at significant level. Self-efficacy was moderately linked in negative direction (r=0.32, p<0.001). Conclusion: As our finding revealed, the occurrence of poor quality of sleep was high among pregnant women during the era of COVID-19 and anxiety, depression and stress were identified as contributor factors. Routine assessment of sleep should be considered along with collaboration of antenatal care and psychiatry units.