Association Between Depressive and Anxiety Disorders and Adherence to Antihypertensive Medication in Community‐Living Elderly Adults

Gentil, Lia; Vasiliadis, Helen Maria; Préville, Michel; Bossé, Cindy; Berbiche, Djamal

doi:10.1111/j.1532-5415.2012.04239.x

Cited by 46 publications

(64 citation statements)

References 29 publications

(44 reference statements)

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“…Adherence to therapy seems to have an association with depression and anxiety disorders in men (but not in women), offering the opportunity for treatment of the disorders to improve outcomes [130]. Even mild anxiety and depression increase the risk of nonadherence [131].…”

Section: Depressionmentioning

confidence: 99%

“…Association between depressive and anxiety disorders and adherence Population-based health survey, Quebec, Canada 2811 community adults, ages 65 and older, final sample 926 subjects who took antihypertensive drugs for 2 years Adherence strongly associated with depression and anxiety disorders in men [130] Sexual activity and function in hypertensive pts (National Social Health, Life and Aging Project) Nationally representative sample of 3005 community-dwelling adults 37-85 years, classified by HT status: treated, untreated, and no HT ACEI, ARB, diuretic, CCB, b-blocker, and a-blocker No significant associations between antihypertensive medication class and sexual activity or problems in men and women Relationship between HT and sexual health did not differ between men and women [143] ED in high-risk HT pts receiving b-blockers ED assessed by the IIED 1007 pts, mean age 57.9 years…”

Section: Referencesmentioning

confidence: 99%

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Tolerability of Antihypertensive Medications in Older Adults

Dharmarajan

2015

Drugs Aging

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Several guidelines for hypertension have recently undergone revisions to incorporate an approach providing choices of medications based on age, race, and specific situations where hypertension may co-exist with disorders such as diabetes, coronary artery disease, heart failure and chronic kidney disease. Initial recommendations include diuretics, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and calcium channel blockers; beta blockers are favored in some guidelines and are a choice in specific settings. Within the classes of drugs, several antihypertensive agents provide options. This review discusses antihypertensive drugs by class, including adverse effects and tolerability, with preferences in older adults and specific settings. Adverse drug events from antihypertensive medications are discussed by class and where applicable for specific agents. Data from select studies pertinent to tolerability and adverse effects are presented in tables for several classes of drugs. The rationale for nonadherence to medication is reviewed, including the roles played by tolerability and adverse drug effects. Antihypertensive therapy in typical settings in older adults is discussed; they include hypertension in association with impaired cognition, depression, diabetes, sexual dysfunction, and falls. The key to successful therapy and tolerability is to promote a healthy lifestyle in conjunction with medications as the approach, thereby also lowering the adverse drug effects. The eventual choice of the specific drug(s) is based on risks, benefits, and patient preferences, and is best tailored for each older adult.

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Section: Depressionmentioning

confidence: 99%

Section: Referencesmentioning

confidence: 99%

Tolerability of Antihypertensive Medications in Older Adults

Dharmarajan

2015

Drugs Aging

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“…Dans une étude plus récente réalisée chez des sujets recevant pour la première fois un traitement anti-HTA, il a été mis en évidence une moins bonne observance chez les femmes [7]. L'observance au traitement anti-HTA serait significativement associée à la dépression et l'anxiété chez les hommes, mais pas chez les femmes [8].…”

Section: Introductionunclassified

Facteurs associés à la non-observance chez les hommes et chez les femmes hypertendus non contrôlés : étude ODACE

Reach

Guedj-Meynier²,

Darné³

et al. 2015

Annales de Cardiologie et d'Angéiologie

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“…Relatedly, given the small sample size, we were not statistically powered to explore whether gender moderates the association of anxiety sensitivity to medication non-adherence, though prior work has shown that depression and anxiety might have differential implications for medication adherence among men and women. 30 Third, we did not conduct comprehensive assessments of psychiatric disorders such as those generated from clinical interviews such as the CAPS for PTSD or the SCID, and thus cannot rule out whether the association of anxiety sensitivity with medication nonadherence is due to confounding from a psychiatric disorder. However, in models that adjusted for depression and PTSD symptoms, and in sensitivity analyses that further adjusted for state anxiety, we continued to see a robust association between anxiety sensitivity and medication nonadherence.…”

Section: Discussionmentioning

confidence: 99%

Anxiety sensitivity and medication nonadherence in patients with uncontrolled hypertension

Alcántara

Edmondson

Moise

et al. 2014

Journal of Psychosomatic Research

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Objective Anxiety sensitivity—fear of the negative social, physical, or cognitive consequences of anxiety related sensations — has been linked to cardiovascular disease and adverse cardiovascular health behaviors. Medication nonadherence may account for this association. We examined whether anxiety sensitivity was independently associated with objectively measured medication nonadherence in a multi-ethnic primary care sample. Methods Eighty-eight patients with uncontrolled hypertension completed the Anxiety Sensitivity Index and had their adherence to blood pressure (BP) medications measured during the interval between two primary care visits using an electronic pillbox (MedSignals®). Multivariable Poisson regressions were conducted to determine the relative risks of medication nonadherence associated with anxiety sensitivity after adjustment for age, gender, Hispanic/Latino ethnicity, education, total number of prescribed medications, and depressive and posttraumatic stress disorder (PTSD) symptoms. Results Nearly twice as many patients with high anxiety sensitivity were nonadherent to BP medications compared to patients with low anxiety sensitivity (65.0% vs. 36.8%; p=0.03). Patients with high anxiety sensitivity had higher relative risks of medication nonadherence than their low anxiety sensitivity counterparts (adjusted relative risk [RR]=1.76; 95% CI: 1.03–3.03). Conclusions In this first study of the association between anxiety sensitivity and medication adherence, we found that high anxiety sensitivity was strongly associated with BP medication nonadherence, even after adjustment for known confounders. Our results suggest that teaching patients who have uncontrolled hypertension adaptive strategies to manage their anxiety sensitivity may help improve their medication adherence, and thereby lower their cardiovascular risk.

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Association Between Depressive and Anxiety Disorders and Adherence to Antihypertensive Medication in Community‐Living Elderly Adults

Cited by 46 publications

References 29 publications

Tolerability of Antihypertensive Medications in Older Adults

Tolerability of Antihypertensive Medications in Older Adults

Facteurs associés à la non-observance chez les hommes et chez les femmes hypertendus non contrôlés : étude ODACE

Anxiety sensitivity and medication nonadherence in patients with uncontrolled hypertension

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