Facteurs associés à la non-observance chez les hommes et chez les femmes hypertendus non contrôlés : étude ODACE

Reach, Gérard; Guedj-Meynier, Dominique; Darné, B.; Herpin, D.

doi:10.1016/j.ancard.2015.04.012

Cited by 7 publications

(13 citation statements)

References 21 publications

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“…Conversely, the number of concurrent medications was reported to be positively associated with adherence in another study . However, our results are consistent with those from ODACE where the number of tablets or treatments other than the anti‐HTN ones was associated with poorer adherence . An interpretation of these findings is that adherence to anti‐HTN treatments, and probably to other treatments, depends on the overall number of tablets prescribed to each patient.…”

Section: Discussionsupporting

confidence: 88%

“…Several studies reported a significant inverse association between adherence and the number of anti‐HTN tablets . In particular, in a review published in 2005, adherence did not seem to correlate with the number of drugs prescribed but decreased with the number of daily takes .…”

Section: Discussionmentioning

confidence: 99%

“…Other factors affecting adherence were age, sex, and class of prescribed antihypertensive drugs . Similarly, in a study involving 873 general practitioners’ attendants in France, the number of tablets was associated with nonadherence among men only, whereas adherence decreased with increasing number of types of drugs among women …”

Section: Introductionmentioning

confidence: 95%

“…The use of validated questionnaire, less costly noninvasive and easily usable in a daily practice, is also common in this area of research . Based on the latter method, studies have shown that age, history of cardiovascular disease (CVD), and social status were positively associated with adherence . Whether sex determines adherence is less clear.…”

Section: Introductionmentioning

confidence: 99%

“…Whether sex determines adherence is less clear. A study of 484 treated hypertensive patients using the “6‐item Girerd compliance test” showed similar levels of adherence to anti‐HTN medication in men and women, whereas another study using the same questionnaire found a better adherence in women . Also, some studies have looked at the association between adherence and the number of tablets.…”

Section: Introductionmentioning

confidence: 99%

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Sex differences in adherence to antihypertensive treatment in patients aged above 55: The French League Against Hypertension Survey (FLAHS)

Lefort

Neufcourt

Pannier³

et al. 2018

J of Clinical Hypertension

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Despite the availability of efficient therapies to reduce the risk of cardiovascular complications, poor adherence to antihypertensive (anti‐HTN) drugs is frequent, especially during the first year of treatment and among uncontrolled/resistant hypertensive patients. The aim of the study was to identify factors associated with adherence to anti‐HTN treatment and to examine whether they differ across sex. A total of 2743 treated hypertensive participants to the cross‐sectional Metascope survey (France, 2015) aged 55 years or more were included. The authors measured adherence to anti‐HTN treatment using the 6‐item Girerd compliance test. Variations in adherence were examined using the Rao‐Scott statistics and Poisson regression. Overall, 63.6% of participants were adherent to anti‐HTN treatment. Adherence was more frequent among women than men (69% vs 58%, P < 10−4). For both sexes, level of adherence was positively associated with age (P < 10−4), but inversely associated with number of anti‐HTN tablets, number of tablets taken for metabolic diseases, history of cardiovascular diseases, number of other chronic diseases (all P < 10−4). The inverse relationship between adherence and the number of anti‐HTN tablets significantly differed between sexes (P < 10−4): Adherence decreased sharply when taking two or more anti‐HTN tablets in men, whereas the decrease in women was only observed when taking three or more anti‐HTN tablets. This study suggests that adherence to anti‐HTN treatment is higher among women, decreases with the number of tablets prescribed, and differentially so across sex. Reducing the number of tablets for anti‐HTN treatment may improve adherence, especially among men and patients with multiple comorbidities.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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