Association between depression and concurrent Type 2 diabetes outcomes varies by diabetes regimen

Abstract

The generally weak association between depression and glycaemic control is concentrated among patients who are prescribed insulin. Similarly, the association between depression and illness quality of life is strongest in patients prescribed insulin. Because this is not attributable to depression-related adherence problems, psychophysiological mechanisms unique to this group ought to be carefully investigated. Clinicians might be especially vigilant for depression in Type 2 DM patients who use insulin and consider its potential impact upon their illness course.

Quality of Life in Medically Ill Persons with Comorbid Mental Disorders: A Systematic Review and Meta-Analysis

“…1). Sixty-five primary studies (69 publications) fulfilled inclusion criteria (diabetes: n = 23 [10,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56]; CAD: n = 26 [57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83]; asthma: n = 13 [84,85,86,87,88,89,90,91,92,93,94,95,96,97]; chronic back pain: n = 3 [98,99,100]; colorectal cancer: n = 0). In most cases, depressive disorders were studied (n = 45), followed by anxiety disorders (n = 14), any mental disorder (i.e.…”

Hypoglycemic Effects of Morus alba Leaf Extract on Postprandial Glucose and Insulin Levels in Patients with Type 2 Diabetes Treated with Sulfonylurea Hypoglycemic Agents

“…Improvements in lifestyle are commonly required, and confections are usually strictly prohibited. However, strict diet therapy may have adverse effects, such as transitory hyperorexia and depression [11][12][13]. To help address these problems, we developed a jelly containing LEM that had suppressive effects on the increments in postprandial glucose and insulin secretion.…”

Psychological problems in patients with type 2 diabetes - clinical considerations

“…Diabetes is clearly associated with impaired healthrelated quality of life, in comparison with the population without diabetes, independently of psychological factors and presence of somatic comorbid diseases 25 , which was shown in many studies 13,[26][27][28] . In one of our studies, the severity of self-rated depressive symptoms in patients with DMT2 significantly inversely correlated with both social adjustment and quality of life 29 .…”