Association between daily walking and antioxidant capacity in patients with symptomatic peripheral artery disease

Abstract

Objective The primary aim of the study was to assess whether both the amount and pace of daily walking were associated with circulating antioxidant capacity in symptomatic patients with peripheral artery disease (PAD). Methods Community-based walking was measured in 244 men and women who were limited by symptomatic PAD during a one week period in which they wore an ankle-mounted step activity monitor. Patients were further characterized on circulating antioxidant capacity with the OxiSelect hydroxyl radical antioxidant capacity (HORAC) activity assay. Results To assess the amount of walking, patients were grouped into low (≤ 2,440 strides/day), middle (2,441–3,835 strides/day), and high stride (>3,835 strides/day) tertiles. HORAC was higher in the middle (p=.03) and high stride tertiles (p=.01) than in the low tertile, but there was no difference between middle and high tertiles (p=.44). To assess the pace of walking, patients were grouped into slow (<25.0 strides/min), middle (25.0–31.6 strides/min), and fast cadence (>31.6 strides/min) tertiles. HORAC was higher in the high cadence tertile than in the low (p<.01) and middle tertiles (p<.01), but there was no difference between low and middle tertiles (p=.48). Similar findings were obtained on group differences in HORAC after adjusting for age, sex, race, and ankle-brachial index for both the amount and pace of daily walking. Conclusions Walking more than 2,440 strides each day, or walking at a cadence faster than 31.6 strides/min for 30 minutes each day are both associated with greater circulating antioxidant capacity in symptomatic patients with PAD. The clinical significance is that a home-based walking program may be one approach to increase endogenous antioxidant capacity.

The Nitric Oxide System in Peripheral Artery Disease: Connection with Oxidative Stress and Biopterins

“…Specifically, manganese superoxide dismutase (MnSOD) [26], glutathione peroxidase [26], and scavenger antioxidants, including vitamin C, have also been shown to be reduced in PAD patients, in association with increasing disease severity [27]. Finally, circulating antioxidant capacity is also reduced in PAD patients and associated with decreasing walking performance [28]. Thus, increased ROS production, along with compromised antioxidant defense systems, has been shown to play an important role in the pathophysiology of PAD.…”

Mobile educational follow-up application for patients with peripheral arterial disease

“…Other studies present the contribution of physical exercise as a therapy to improve walking distance without presenting intermittent claudication and an increase in the Ankle-Brachial Index (ABI) in the short- and medium-term associated with pharmacological treatment and/or intervention 28 - 31 .…”

Scoping Review of Healthcare Literature on Mobile, Wearable, and Textile Sensing Technology for Continuous Monitoring

“…Figure 8 groups' devices are based on two general body areas: the upper body where devices are worn/carried, such as glasses, necklaces, and watches, and the lower body where devices are worn/carried on the waist, in a pocket, on the ankle, and in/on the shoes. This scoping review shows that there are three times as many articles about wearable technology than articles about mobile devices that are positioned on the chest/ 2014 [24,25] 2015 [26] 2016 [27][28][29][30][31][32][33] 2017 [34][35][36][37][38][39][40][41][42][43][44][45][46] 2018 [47][48][49][50] 2019 [51,52] Fig. 5 Validation of research conducted.…”