Association between cyclic variation in the heart rate index and biomarkers of neurodegenerative diseases in obstructive sleep apnea syndrome: A pilot study

Tsai, Cheng-Yu; Liu, Yi-Shin; Majumdar, Arnab; Houghton, Robert; Lin, Shang‐Yang; Lin, Yi; Ho, Shu-Chuan; Cheng, Wun-Hao; Liu, Wen‐Te; Wu, Dean; Lee, Hsin Chien; Kuan, Yi‐Chun; Hsu, Wei-Han; Hsu, Shin-Mei; Lo, Chen-Chen; Chiu, Po-Chieh; Chen, You-Rong; Lo, Kang; Chen, Chia-I; Lai, Hsiang-Jung; Chen, Chun-Yu

doi:10.1016/j.jocn.2022.01.019

Cited by 5 publications

(2 citation statements)

References 38 publications

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“…Sixty‐seven papers were further excluded after screening titles and abstracts, leaving 10 citations for full‐text review. Three papers were subsequently excluded for the following reasons: One study defined OSA using a questionnaire (Huang et al., 2021 ); another study divided patients into normal‐to‐moderate and severe OSA groups (Tsai, Liu, et al., 2022 ); one study did not group by OSA severity (Tsai, Wu, et al., 2022 ). At last, seven papers were considered eligible for the meta‐analysis.…”

Section: Resultsmentioning

confidence: 99%

The relationship between obstructive sleep apnea and circulating tau levels: A meta‐analysis

et al. 2023

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Background Alzheimer's disease (AD) is an irreversible, progressive brain disorder that impairs memory, thinking, language, and, eventually, the ability to carry out the simplest of tasks. Tau protein, the major component of neurofibrillary tangles, is considered a key mediator of AD pathogenesis. The association between obstructive sleep apnea (OSA) and circulating tau remains unclear. The aim of the present meta‐analysis was to evaluate the relationship between OSA and circulating tau via quantitative analysis. Methods A systematic search of Pubmed, Embase, and Web of Science were performed. The mean values of circulating total tau (T‐tau) and phosphorylated tau (P‐tau) in OSA and control groups were extracted. Standardized mean difference (SMD) with 95% confidence interval (CI) was calculated by using a random‐effect model or fixed‐effect model. Results A total of seven studies comprising 233 controls and 306 OSA patients were included in this study. The meta‐analysis showed that the circulating T‐tau level was significantly higher in OSA patients than those in the control group (SMD = 1.319, 95% CI = 0.594 to 2.044, z = 3.56, p < .001). OSA patients also had significantly higher circulating P‐tau level than control group (SMD = 0.343, 95% CI = 0.122 to 0.564, z = 3.04, p = .002). Conclusions The present meta‐analysis demonstrated that both circulating T‐tau and P‐tau levels were significantly increased in OSA subjects when compared with non‐OSA subjects. Larger sample‐size studies on the association between OSA and circulating tau are still required to further validate our results.

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Section: Resultsmentioning

confidence: 99%

The relationship between obstructive sleep apnea and circulating tau levels: A meta‐analysis

et al. 2023

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“…An association between the depletion of myeloid and plasmatic dendritic cells was also demonstrated, which correlates with the already known assumption that IL-6 is an inhibitor for the maturation of dendritic cells ( 34 ). Chronically high levels of proinflammatory cytokines may induce neuroinflammation and/or neurodegeneration ( 49 ), which is interesting because OSA is suspected to have neurodegenerative features ( 44 , 50 ) and sleep disorders such as OSA occur or worsen in patients with neurodegenerative diseases, such as Parkinson's disease, Alzheimer disease or amyotrophic lateral sclerosis ( 51 – 53 ).…”

Section: Discussionmentioning

confidence: 99%

Cellular Immune Dysfunction in Obstructive Sleep Apnea

et al. 2022

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Obstructive sleep apnea (OSA) is the most common sleep-related breathing disorder. Repetitive pauses in breathing during sleep cause a brief but recurrent decrease in oxygen saturation in organs and tissues (chronic intermittent tissue hypoxia). Many studies have proven a pro-inflammatory status in OSA patients. However, few reports are available on the effects of OSA on the cellular immune system, mostly focusing on single immune cell types and their subtypes. The aim of this Mini-Review is to summarize these reports, as OSA is associated with a high prevalence and comorbidities such as atherosclerosis, which are known to involve the cellular immune system.

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A systematic review with meta-analysis to assess Alzheimer's disease biomarkers in adults with or without obstructive sleep apnoea

Mohammadi,

Adibparsa,

Najafi

et al. 2023

International Orthodontics

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Association between cyclic variation in the heart rate index and biomarkers of neurodegenerative diseases in obstructive sleep apnea syndrome: A pilot study

Cited by 5 publications

References 38 publications

The relationship between obstructive sleep apnea and circulating tau levels: A meta‐analysis

The relationship between obstructive sleep apnea and circulating tau levels: A meta‐analysis

Cellular Immune Dysfunction in Obstructive Sleep Apnea

A systematic review with meta-analysis to assess Alzheimer's disease biomarkers in adults with or without obstructive sleep apnoea

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