Association between coronary heart disease and the apolipoprotein A-I/C-III/A-IV complex in a Japanese population

Abstract

Several studies have reported that a variant allele (S2) of the apolipoprotein (apo) A-I/C-III/A-IV complex is associated with hyperlipoproteinemia in some populations and that the frequency of this allele is two- to fivefold higher in patients with premature coronary heart disease (CHD) than in healthy controls. In the present study in a Japanese population, we were unable to confirm the association of the S2 allele with either coronary heart disease or elevated serum apo C-III levels, as has been previously reported in Caucasians. No genotype difference was observed among the severity of coronary heart disease, as determined by the number of involved vessels (one, two and three vessel disease), compared to controls. In addition, the frequency of the S2 allele among Japanese, in both CHD (0.328) and controls (0.369), was quite different from that in many other populations.

Apolipoprotein CIII polymorphism and triglyceride levels of a Japanese population living in Southern Brazil

“…In the present study, the G allele frequency in NTG and HTG subjects were 0.347 and 0.559, respectively. The G allele frequency is consistent with ranges reported for Chinese (0.30-0.43) (16), Japanese (0.25-0.48) (18), and Indians (0.36) (20), but is higher than those reported for Caucasians in whom the G allele frequency was 0.00-0.11 (3,(19)(20)(21)(22). The clinical significance of possessing this allele has been demonstrated in some case-control studies that showed a 2-to 5-fold increase in frequency in patient groups with premature coronary heart disease and peripheral vascular disease compared with control groups (23,24).…”

Effect of SstI Polymorphism of the Apolipoprotein CIII Gene and Environmental Factors on Risks of Hypertriglyceridemia in Taiwan Aborigines

“…16 The present study found frequencies of the S2 allele in NTG and HTG subjects of 0.26 and 0.34, respectively. The frequency of the S2 allele is in line with ranges reported for Chinese (0.30-0.43), 16 Japanese (0.25-0.48), 12,27 and Indians (0.31), 13 but is higher than those reported for Caucasians in whom the frequencies of the S2 allele have been 5-10% in most reports (0.0-0.11). 14,15,28,29 The clinical significance of possessing this allele has been demonstrated in some casecontrol studies that showed a 2-to 5-fold increase in frequency in patient groups with premature coronary heart and peripheral vascular disease compared with control groups.…”

“…Furthermore, recent mitochondrial DNA analysis supports the link between Taiwan aborigines and Polynesians. 26 Associations between the rare S2 allele of ApoCIII and elevated TG have been reported in various different ethnic groups, including Japanese, 12 Asian Indians, 13 Arabs, 14 Caucasians, 15 and Chinese. 16 The present study found frequencies of the S2 allele in NTG and HTG subjects of 0.26 and 0.34, respectively.…”

Polymorphisms in Four Genes Related to Triglyceride and HDL-cholesterol Levels in the General Japanese Population in 2000

“…Although a association of higher TG levels with the S2 allele has been reported in studies carried out in Caucasians (44)(45)(46) and Asians (47)(48)(49), our data show that such an association was found in the total population and in men, but not in women. Few other studies, however, have found any significant association between the Sst1 polymorphism and hypertriglyceridemia (50)(51)(52). The linkage disequilibrium between this polymorphism and the causative mutation might be weakened or absent in some populations (44).…”