Effect of SstI Polymorphism of the Apolipoprotein CIII Gene and Environmental Factors on Risks of Hypertriglyceridemia in Taiwan Aborigines

Huang, Meng‐Chuan; Wang, Tsu‐Nai; Liu, Yiling; Pa, Te-Hsiung; Tu, Hung-Pin; Huang, Yi‐Chia; Chang, Wen Tsan; Ko, Ying‐Chin

doi:10.1253/circj.70.1030

Cited by 16 publications

(22 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on population-based studies, there is an association between the level of TG and the ApoAI-CIII-AIV gene cluster in individuals with hyper triglyceridemia [5]. Increasing the level of TG is a major independent risk factor for CAD across populations from America [6,7], Europe [8,9], and Asia [10,11]. In addition, there are other studies assessing the association between ApoE and ApoB gene polymorphisms with lipid levels in Iranians [12], and they show that this population has an inherent tendency for dyslipidemia associated with high risk of CAD [12,13].…”

Section: Introductionmentioning

confidence: 99%

Haplotype analysis of Apo AI-CIII-AIV gene cluster and lipids level: Tehran lipid and glucose study

et al. 2011

View full text Add to dashboard Cite

Iranian populations show an increased tendency for abnormal lipid levels and high risk of Coronary artery disease. Considering the important role played by the ApoAI-CIII-AIV gene cluster in the regulation of the level and metabolism of lipids, this study aimed at elucidating the association between five single nucleotide polymorphisms on the Apo11q cluster gene and lipid levels. A cross-sectional study of 823 subjects (340 males and 483 females) from the Tehran lipid and glucose study (TLGS) was conducted. Levels of TG, Chol, HDL-C, Apo AI, Apo AIV, Apo B, and Apo CIII were measured, and the selected segments of the APOAI-CIII-AIV gene cluster were amplified by PCR and the polymorphisms were revealed by RFLP using restriction enzymes. The allele frequencies for each SNP between males and females were not significantly different. The distribution of Genotypes and alleles was in Hardy-Weinberg equilibrium except for Apo AI (+83C>T). The results showed a significant association between TG, HDL-C, HDL(2), Apo AI, and Apo B levels and the presence of some alleles in the polymorphisms studied. After haplotype analysis not only did the association between these variables and SNPs remain but also levels of Chol and LDL-C were added. This study demonstrates that the level of lipids such as TG, HDL-C, HDL(2), Apo AI, and Apo B, maybe regulated partly by genetic factors and their haplotype within the Apo11q gene cluster.

show abstract

Section: Introductionmentioning

confidence: 99%

Haplotype analysis of Apo AI-CIII-AIV gene cluster and lipids level: Tehran lipid and glucose study

et al. 2011

View full text Add to dashboard Cite

show abstract

“…The ApoC3 SstI polymorphism has been associated with altered plasma triglyceride concentrations. 10 Recently, definitive Nterminal protein sequences obtained from ApoA5 purified from human serum were demonstrated. 11 The actual N-terminal sequence of ApoA5 corresponds to that expected from cleavage of the predicted signal peptide, indicating that the mature protein is an intact molecule with a predicted relative molecular mass (Mr) of 39 kDa.…”

mentioning

confidence: 99%

Strong Linkage Disequilibrium and Association of -1131T>C and c.553G>T Polymorphisms of the Apolipoprotein A5 Gene With Hypertriglyceridemia in a Japanese Population

Matsunaga

Arishima

Niimura

et al. 2007

Circ J

View full text Add to dashboard Cite

BackgroundThe apolipoprotein A5 gene (ApoA5) plays an important role in modulating triglyceride metabolism. Polymorphisms of ApoA5, including -1131T>C and c.553G>T (G185C), have been reported to correlate with hypertriglyceridemia (HTG). In the present study the relationships of 5 single nucleotide polymorphisms, including the -1131T>C, c.56C>G, IVS3+476G>A, c.553G>T, and c.1259T>C polymorphisms of ApoA5, with HTG were investigated. Methods and ResultsThe study group comprised 95 Japanese patients with HTG and 119 unrelated normolipidemic subjects. Frequencies of the C allele of -1131T>C (0.511) and the T allele of c.553G>T (0.205) in the hypertriglyceridemic patients were significantly higher than in the normolipidemic subjects (0.315 and 0.105, respectively). The c.56C>G (S19W) polymorphism was not observed, and the other 4 polymorphic sites were in strong linkage disequilibrium. Five of the 8 detected haplotypes with the C allele of -1131T>C correlated with HTG. Promoter activities of ApoA5, including that with the -1131T>C polymorphism, were estimated using a luciferase assay. Analysis of ApoA5 promoters showed that the -1131T>C polymorphism alone had no effect. Comparison of expression of mutant G185C and wild-type ApoA5-green fluorescent protein (GFP) in HepG2 cells showed that ApoA5-GFP was abundant in punctate endosome-like structures, and ApoA5 (G185C)-GFP expression resembled that of the wild type. Conclusions The -1131T>C and c.553G>T (G185C) polymorphisms correlated with HTG in this Japanese population, but neither polymorphism directly affected ApoA5 expression. (Circ J 2007; 71: 746 -752)

show abstract

“…The most extensively studied one is the SstI polymorphism located in the 3'UTR of the gene (20). Associations of the minor allele S2 with higher levels of TG (21)(22)(23)(24)(25)(26) and lower levels of HDL-C (27) have been reported in various ethnic groups. However, the interactions of this genetic variant with a high-CHO diet on the ratios of serum lipids and apolipoproteins have not been reported before.…”

Section: Discussionmentioning

confidence: 99%

“…The SstI polymorphism is formed by a transversion from C to G and is located in the 3' untranslated region (3'UTR) of this gene (20). A number of studies have reported that the S2 carriers of the APOC3 SstI polymorphism had higher plasma levels of TG (21)(22)(23)(24)(25)(26), TC (27,28), LDL-C (27), and lower levels of HDL-C (27). The S2 allele was also associated with elevated plasma concentrations of apoCIII (29,30) and apoB (27,29,30), but not with lower apoAI levels (29).…”

mentioning

confidence: 99%

“…Previous studies have shown that both the high-CHO diet and the APOC3 SstI polymorphism affect the serum lipid and lipoprotein profiles (11,12,(21)(22)(23)(24)(25)(26)(27)(28)(29)(30). Therefore, we supposed that the different genotypes of the APOC3 SstI polymorphism may have different responses to the high-CHO diet regarding the ratios of serum lipids and apolipoproteins.…”

mentioning

confidence: 99%

See 1 more Smart Citation

A high-carbohydrate diet enhances the adverse effect of the S2 allele of APOC3 SstI polymorphism on the TG/HDL-C ratio only in young Chinese females

Song

Gong

Zhang

et al. 2011

Braz J Med Biol Res

View full text Add to dashboard Cite

Effect of SstI Polymorphism of the Apolipoprotein CIII Gene and Environmental Factors on Risks of Hypertriglyceridemia in Taiwan Aborigines

Cited by 16 publications

References 47 publications

Haplotype analysis of Apo AI-CIII-AIV gene cluster and lipids level: Tehran lipid and glucose study

Haplotype analysis of Apo AI-CIII-AIV gene cluster and lipids level: Tehran lipid and glucose study

Strong Linkage Disequilibrium and Association of -1131T>C and c.553G>T Polymorphisms of the Apolipoprotein A5 Gene With Hypertriglyceridemia in a Japanese Population

A high-carbohydrate diet enhances the adverse effect of the S2 allele of APOC3 SstI polymorphism on the TG/HDL-C ratio only in young Chinese females

Contact Info

Product

Resources

About