Association between congenital heart defects and severe infections in children with Down syndrome

Faria, Paula Foresti; Nicolau, Juliana Augusta Zeglin; Melek, Marina Zaponi; Oliveira, Nanci de; Bermudez, Beatriz Elizabeth Bagatin Veleda; Nisihara, Renato

doi:10.1016/j.repce.2013.05.008

Cited by 11 publications

(21 citation statements)

References 13 publications

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“…En fazla karşılaştığımız sendrom Down sendromu idi. Down sendromlu çocuklarda kardiyak anomali riski yüksektir 22 . Kalp kapak hastalıkları diş çekimi yapılan hastalarda endokardit profilaksisi gerektirir.…”

Section: Dişunclassified

Genel anestezi altında dental tedavi yapılan olguların değerlendirilmesi

Akpınar

2019

Cukurova Medical Journal

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Öz Purpose: General anesthesia applications in dentistry are becoming increasingly widespread. Risks related to anesthesia should be seriously questioned in the patient group under dental treatment planning under general anesthesia. We aimed to evaluate the clinical and demographic data of patients who were operated with general anesthesia and sedation during our study in our hospital, and discussed in the light of the literature. Materials and Methods: A retrospective study of 3380 cases treated between April 2014 and April 2016 was reviewed. Demographic data obtained from patient files, ASA Scores, length of hospital stay,type of anesthesia, duration of anesthesia,complications occurring, anesthetic agents and analgesics used, patients with syndrome and the desired consultations were evaluated Results: Of the 3380 cases, 55% were female, 45% were male and the mean age was 11.23 ± 12.09. The distribution according to ASA scores was 84.4% ASA I, 15.2% ASA II, 0.4% ASA III. In 3085 patients the procedure was performed by outpatient surgery procedure, while 276 patients were treated inpatient. The consultations requested from the patients were mostly from the pediatric and neurology clinics. The most common postoperative complication was bradycardia, and the least complication was difficult intubation. The most common causes of comorbidities were mental retardation, congenital heart disease, and epilepsy. Conclusion: The method of anesthesia is also important especially in the pediatric age group due to the frequency of genetic syndromes, mental retardation, concomitant cardiac and respiratory problems. Precautions should be taken to avoid mortality and morbidity due to anesthesia. Vital risks should be avoided.

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Section: Dişunclassified

Genel anestezi altında dental tedavi yapılan olguların değerlendirilmesi

Akpınar

2019

Cukurova Medical Journal

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“…Entre os achados clínicos, uma preocupação constante é a alta prevalência de cardiopatia congênita, e o objetivo do presente estudo é determinar a prevalência e o perfil de cardiopatia congênita em pacientes atendidos em um ambulatório The prevalence of serious infections such as pneumonia and sepsis is high (70% and 85% respectively) among children with Down syndrome and congenital heart disease between the ages of six and 48 months. 4 Clinical follow-up and periodic vaccination, including use of the antibody against respiratory syncytial virus, is therefore important.…”

Section: Introductionunclassified

Down syndrome: Prevalence and distribution of congenital heart disease in Brazil

et al. 2015

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CONTEXT AND OBJECTIVE: Down syndrome is the most common genetic disorder, affecting 1/700 live births. Among the clinical findings, one constant concern is the high prevalence of congenital heart disease. The objective of this study was to determine the prevalence and profile of congenital heart disease among patients attended at a Down syndrome outpatient clinic in southern Brazil between 2005 and 2013. DESIGN AND SETTING: Cross-sectional study conducted in a referral center. METHODS: Data were retrospectively gathered from the medical files of 1,207 patients with Down syndrome, among whom 604 (50.0%) had been diagnosed with congenital heart disease. These data were subjected to descriptive analysis using the Statistica software. RESULTS: Among the 604 patients with congenital heart disease, 338 (55.8%) were male and 269 (44.5%) were female. The most common heart diseases were atrial septal defect in 254 patients (42.1%); total atrioventricular septal defect in 91 (15.1%); atrial septal defect and ventricular septal defect in 88 (14.6%); ventricular septal defect in 77 (12.7%); patent ductus arteriosus in 40 (6.6%); patent foramen ovale in 34 (5.6%) patients; tetralogy of Fallot in 12 (2%); and other diseases in 8 (1.3%). Pulmonary hypertension was present in 57 (9.4%). Out of the total, 150 patients (24.8%) underwent cardiac surgery. CONCLUSION: The high prevalence of congenital heart disease among the patients at the Down syndrome outpatient clinic (50%) was similar to findings from other studies and justifies investigation during the neonatal period, so as to decrease mortality and morbidity. RESUMO

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“…Risk factors for ventilator-associated pneumonia were PRISM III score > 10 and transfusion of fresh-frozen plasma. 12 Epidemiology of perioperative infections in low-and middle-income countries Among 21 studies in low-and middle-income countries, four were conducted in China, [43][44][45][46] four in India, [47][48][49][50] three in Brazil, [51][52][53] two in Saudi Arabia 54,55 , and one each in Argentina, 56 Bosnia Herzegovina, 57 Iran, 58 Ethiopia, 59 Guatemala, 60 and Sudan. 61 One multicentre study involving 17 low-to middle-income countries included India, Pakistan, Colombia, Russia, China, Dominican Republic, Brazil, Argentina, El Salvador, Ukraine, Peru, Mexico, Belarus, Vietnam, Uganda, Guatemala, and Bangladesh.…”

Section: Epidemiology Of Perioperative Infections In High-income Counmentioning

confidence: 99%

“…61 One multicentre study involving 17 low-to middle-income countries included India, Pakistan, Colombia, Russia, China, Dominican Republic, Brazil, Argentina, El Salvador, Ukraine, Peru, Mexico, Belarus, Vietnam, Uganda, Guatemala, and Bangladesh. 62 There were five different study designs including one randomised controlled trial, 53 one non-randomised interventional before-after study, 62 16 cohort studies, [43][44][45][47][48][49][50]52,[54][55][56][57]59,60,63 one case-control study, 51 and three cross-sectional studies. 46,58,61 Most studies were conducted in children, with two in neonates 47,57 and two involving children and adult patients.…”

Section: Epidemiology Of Perioperative Infections In High-income Counmentioning

confidence: 99%

Perioperative infections in congenital heart disease

et al. 2017

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Background: Perioperative infections have significant consequences for children with congenital heart disease (CHD), which can manifest as acute or chronic infection followed by poor growth and progressive cardiac failure. The consequences include delayed or higher-risk surgery, and increased postoperative morbidity and mortality. Methods: A systematic search for studies evaluating the burden and interventions to reduce perioperative infections in children with CHD was undertaken using PubMed. Results: Limited studies conducted in low-to middle-income countries demonstrated the large burden of perioperative infections among children with CHD. Most studies focussed on infections after surgery. Few studies evaluated strategies to prevent preoperative infection or the impact of infection on decision-making around the timing of surgery. Children with CHD have multiple risk factors for infections including delayed presentation, inadequate treatment of cardiac failure, and poor nutrition. Conclusions: The burden of perioperative infections is high among children with CHD, and studies evaluating the effectiveness of interventions to reduce these infections are lacking. As good nutrition, early corrective surgery, and measures to reduce nosocomial infection are likely to play a role, practical steps can be taken to make surgery safer.

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Association between congenital heart defects and severe infections in children with Down syndrome

Cited by 11 publications

References 13 publications

Genel anestezi altında dental tedavi yapılan olguların değerlendirilmesi

Genel anestezi altında dental tedavi yapılan olguların değerlendirilmesi

Down syndrome: Prevalence and distribution of congenital heart disease in Brazil

Perioperative infections in congenital heart disease

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