Association between condylar morphology and changes in bony microstructure and sub-synovial inflammation in experimental temporomandibular joint arthritis

Kristensen, Kasper Dahl; Hauge, Ellen Margrethe; Dalstra, Michel; Stoustrup, Peter; Küseler, Annelise; Pedersen, Thomas Klit; Herlin, Troels

doi:10.1111/j.1600-0714.2010.00934.x

Cited by 17 publications

(14 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the light of radiodensitometric analysis, the present study indicated a significantly greater amount of mineralized bone (1.74 times greater) in the ZA-treated group. In the literature, it was reported that the experimental TMJ arthritis resulted in low degree of mineralization compared to healthy condyles and was associated with morphological changes [24]. According to this background with the result of the present study, adjunct antiresorptive effects of ZA may theoretically support the treatment of TMJ arthritis by improving bone mineralization.…”

Section: Discussionsupporting

confidence: 76%

Effects of Zoledronic Acid on Physiologic Bone Remodeling of Condylar Part of TMJ: A Radiologic and Histomorphometric Examination in Rabbits

Tatlı

Üstün

Kürkçü

et al. 2014

The Scientific World Journal

View full text Add to dashboard Cite

Objective. The purpose of the present study is to evaluate the effects of systemically administered zoledronic acid (ZA) on the physiological bone remodeling and the microarchitectural parameters of the condylar part of TMJ in a rabbit model. Study Design. Thirty skeletally mature male New Zealand white rabbits were randomly divided into two groups. The experimental group was administered an intravenous, single dose of 0.1 mg/kg ZA diluted with 15 mL of saline in a 15-minute perfusion with an infusion pump. The control group was administered only saline infusion for 15 minutes. All rabbits were sacrificed on the 21st postoperative day. Radiodensitometric and histomorphometric examinations were performed on the harvested mandibular condyles. The data were analyzed statistically. Results. Radiodensitometric findings showed that ZA treatment resulted in a significant increase in the mineralization of mandibular condyle. This result was supported by the histomorphometric findings. Conclusion. The present study has revealed that a temporary delay in the physiological bone remodeling using single dose of ZA increases bone mineral content and makes the microarchitecture of the mandibular condyle more compact. These effects may be regarded as base data and considered in numerous clinical situations including TMJ.

show abstract

Section: Discussionsupporting

confidence: 76%

Effects of Zoledronic Acid on Physiologic Bone Remodeling of Condylar Part of TMJ: A Radiologic and Histomorphometric Examination in Rabbits

Tatlı

Üstün

Kürkçü

et al. 2014

The Scientific World Journal

View full text Add to dashboard Cite

show abstract

“…20 It can either be primary or secondary to trauma, abnormal morphology, or other acute or chronic overload situations. 21,22 Genetic influence has also been described in humans. 23 With that in mind, it is important to reflect on the unique adaptation of jaw function to a novel marine behaviour of non-masticatory eating and a large estimated bite force due to the heavy jaw musculature of California sea lions.…”

Section: Discussionmentioning

confidence: 94%

The temporomandibular joint of California sea lions (Zalophus californianus): Part 1 – Characterisation in health and disease

Arzi

Murphy

Leale

et al. 2015

Archives of Oral Biology

View full text Add to dashboard Cite

“…12,21 The pathogenesis of osteoarthritis of the TMJ is characterized by erosion, deterioration, and abrasion of the articular fibrocartilage as well as localized thickening and remodeling of the subchondral bone and development of marginal osteophytes. 12,13,22 …”

Section: Discussionmentioning

confidence: 99%

Computed tomographic findings in dogs and cats with temporomandibular joint disorders: 58 cases (2006–2011)

Arzi

Cissell²,

Verstraete

et al. 2013

javma

133

View full text Add to dashboard Cite

Objective To describe CT findings in dogs and cats with temporomandibular joint (TMJ) disorders. Design Retrospective case-series. Animals 41 dogs and 17 cats. Procedures Medical records and CT images of the skull were reviewed for dogs and cats that were examined at a dentistry and oral surgery specialty practice between 2006 and 2011. Results Of 142 dogs and 42 cats evaluated, 41 dogs and 17 cats had CT findings consistent with a TMJ disorder. In dogs, the most common TMJ disorder was osteoarthritis; however, in most cases, there were other TMJ disorders present in addition to osteoarthritis. Osteoarthritis was more frequently identified at the medial aspect rather than the lateral aspect of the TMJ, whereas the frequency of osteoarthritic involvement of the dorsal and ventral compartments did not differ significantly. In cats, fractures were the most common TMJ disorder, followed by osteoarthritis. Clinical signs were observed in all dogs and cats with TMJ fractures, dysplasia, ankylosis, luxation, and tumors; however, only 4 of 15 dogs and 2 of 4 cats with osteoarthritis alone had clinical signs. Conclusions and Clinical Relevance Results indicated that TMJ disorders are frequently present in combination. Osteoarthritis was the most common TMJ disorder in dogs and the second most common TMJ disorder in cats. Computed tomography should be considered as a tool for the diagnosis of TMJ disorders in dogs and cats with suspected orofacial disorders and pain.

show abstract

Association between condylar morphology and changes in bony microstructure and sub-synovial inflammation in experimental temporomandibular joint arthritis

Abstract: We showed that severe inflammation in the TMJs during mandibular development was associated with morphological changes in the mandibular condyle. These changes were predominantly seen at the macro-morphological level and only very few differences were structural.

Cited by 17 publications

References 29 publications

Effects of Zoledronic Acid on Physiologic Bone Remodeling of Condylar Part of TMJ: A Radiologic and Histomorphometric Examination in Rabbits

Effects of Zoledronic Acid on Physiologic Bone Remodeling of Condylar Part of TMJ: A Radiologic and Histomorphometric Examination in Rabbits

The temporomandibular joint of California sea lions (Zalophus californianus): Part 1 – Characterisation in health and disease

Computed tomographic findings in dogs and cats with temporomandibular joint disorders: 58 cases (2006–2011)

Contact Info

Product

Resources

About