Association between clinical measures of gingival inflammation and obesity in adults: systematic review and meta-analyses

Silva, Fernanda Gonçalves da; Pola, Natália Marcumini; Casarin, Maísa; Silva, Caroline Fernandes e; Muniz, Francisco Wilker Mustafa Gomes

doi:10.1007/s00784-021-03961-1

Cited by 18 publications

(32 citation statements)

References 106 publications

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“…In "healthy" adults, high upper body obesity or high total body fat significantly increased the adjusted risk of periodontitis compared with nonobese subjects 13 . A correlation between body mass index, waist‐to‐hip ratio, and periodontal measures, such as periodontal attachment loss, pocket depth, and gingival bleeding, was established 15,17 . Central adiposity was significantly correlated with an increased risk of periodontal disease 18 .…”

Section: Epidemiologic Evidence On the Link Between Periodontal Disea...mentioning

confidence: 99%

“…Data from the Third National Health and Nutrition Examination Survey indicate a significant association between body fat and periodontal disease among younger adults, 11 suggesting that obesity could be an early risk factor for periodontitis. As a measure of obesity, a strong association between body mass index and periodontal diseases has also been reported 14,17 . In "healthy" adults, high upper body obesity or high total body fat significantly increased the adjusted risk of periodontitis compared with nonobese subjects 13 .…”

Section: Epidemiologic Evidence On the Link Between Periodontal Disea...mentioning

confidence: 99%

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Inflammation as a link between periodontal disease and obesity

Pamuk

Kantarcı²

2022

Periodontology 2000

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periodontal inflammation is much less explored. A recent study demonstrated that a healthy diet is associated with a reduced risk for periodontitis in younger individuals, 9 suggesting that earlier interventions and dietary habits are critical for inflammatory changes. This review will focus on the potential mechanistic links between periodontal diseases and obesity while discussing the potential and common inflammatory activity pathways that can be pharmacologically targeted.

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Section: Epidemiologic Evidence On the Link Between Periodontal Disea...mentioning

confidence: 99%

Section: Epidemiologic Evidence On the Link Between Periodontal Disea...mentioning

confidence: 99%

Inflammation as a link between periodontal disease and obesity

Pamuk

Kantarcı²

2022

Periodontology 2000

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“…GI is based on a combination of visual evaluation and mechanical stimulus of marginal periodontal tissues. GI scores demonstrated a significant correlation with histological parameters of inflammation during the development of periodontal disease ( da Silva et al, 2021 ). SBI provides an objective assessment for detecting early inflammatory changes in inflammatory lesions, which are sometimes difficult to visually examine ( Newman, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Efficacy of Curcumin as an Adjunct to Non-Surgical Periodontal Treatment: A Systematic Review and Meta-Analysis

et al. 2022

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Objective: Curcumin has been used as an adjunct to non-surgical periodontal treatment. However, the efficacy of curcumin in the periodontal therapy remained controversial. This study aimed to evaluate the anti-inflammatory efficacy of curcumin as an adjunct to non-surgical periodontal treatment (NPT) by systematic review.Methods: Databases including Embase, PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), and ClinicalTrials.gov were searched to identify relevant RCTs on the use of curcumin as an adjunct to NPT for the treatment of periodontal disease from inception to July 21, 2021. Two reviewers independently screened literature, extracted data and assessed the risk of bias of the included studies. Meta-analysis was then performed using Review Manager 5.3 software.Results: A total of 18 RCTs involving 846 patients/sites were included in this meta-analysis. The results of the meta-analysis revealed that as compared to NPT alone, curcumin as an adjunct to NPT resulted in significant reduction in gingival index (GI) at the 1-week (mean differences (MD) = −0.15, 95% confidence intervals (CI) −0.26 to −0.05, p = 0.005), 2-week (MD = −0.51, 95%CI −0.74 to −0.28, p < 0.0001), 3-week (MD = −0.34, 95%CI −0.66 to −0.02, p = 0.03), 4-week (MD = −0.25, 95%CI −0.48 to −0.02, p = 0.04) or 6-week (MD = −0.33, 95%CI −0.58 to −0.08, p = 0.01) follow-ups. Similar significant reductions were also observed for sulcus bleeding index (SBI) at 1, 2, 4, and 12 weeks. However, there were no statistically significant differences in reducing bleeding on probing (BOP) between curcumin as an adjunct and NPT alone at 4, 12, and 24 weeks.Conclusion: Based on the current evidence, curcumin demonstrates anti-inflammatory efficacies in terms of reducing GI and SBI compared with NPT alone. Moreover, curcumin is a natural herbal medicine with few side effects, and it is a good candidate as an adjunct treatment for periodontal disease.

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“…99 Conversely, a systematic review and metaanalysis demonstrated that a significantly higher level of gingival inflammation is observed in obese people than in nonobese people. 100 Two separate systematic reviews have confirmed these associations and concluded that overweight, obesity, and weight gain are associated with periodontal disease, suspecting that increased amount of lipids could contribute to the propagation of the inflammatory response leading to severe periodontal disease. 101,102 Nevertheless, a 10-year retrospective study showed that, in spite of an increased incidence of periodontal disease progression in obese subjects, obesity is not an independent risk factor for progression of periodontitis when confounders were analyzed simultaneously.…”

Section: Obesitymentioning

confidence: 98%

Periodontitis and implant complications in diabetes

Nibali

Gkranias

Mainas

et al. 2022

Periodontology 2000

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Diabetes mellitus and periodontal disease are among the most common chronic diseases of mankind 1-3 and, remarkably, they share many common features. Periodontal diseases encompass a group of diseases affecting the supporting apparatus of the teeth, including gingiva, root cementum, periodontal ligament, and alveolar bone.The most common forms of periodontal diseases, gingivitis and periodontitis, are characterized by a microbially driven series of host responses that lead to periodontal tissue damage. 4,5 The host response is central to the development of periodontitis, as it is to the development and progression of several human chronic diseases, including diabetes mellitus. In the next sections we will review the main features of diabetes mellitus, with the main focus being the association between type 2 diabetes mellitus and periodontitis. | Diabetes mellitusDiabetes mellitus is a complex chronic disease requiring continuous and multiple interventions on glycemic targets and cardiovascular risk factors in order to prevent acute and chronic complications.According to the current World Health Organization classification, there are two major types of diabetes mellitus: type 1 and type 2 (https://www.who.int/publi catio ns/i/item/class ifica tion-of-diabe tes-mellitus). The two forms are heterogeneous diseases in which physiopathology, clinical presentation, and disease progression vary considerably.

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Association between clinical measures of gingival inflammation and obesity in adults: systematic review and meta-analyses

Cited by 18 publications

References 106 publications

Inflammation as a link between periodontal disease and obesity

Inflammation as a link between periodontal disease and obesity

Anti-Inflammatory Efficacy of Curcumin as an Adjunct to Non-Surgical Periodontal Treatment: A Systematic Review and Meta-Analysis

Periodontitis and implant complications in diabetes

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