Association Between Clinical Depression and Endothelial Function Measured by Forearm Hyperemic Reactivity

Abstract

Patients with clinical levels of depression had worse FHR than patients without depression, irrespective of CHD status and after adjusting for covariates. Data extend previous findings, suggesting that the link between clinical depression and worse CHD outcomes may be mediated by EF.

Association Between Endothelial Dysfunction and Depression-Like Symptoms in Chronic Mild Stress Model of Depression

“…4). In humans, endothelial dysfunction (2,3) was reported in patients with major depression, where impaired forearm flow-mediated vasodilatation was seen (8Y10, 33,39,40). In addition, reduced NO-dependent relaxation has been shown in studies of large arteries from rats (30,31) and mice (29,32) exposed to CMS.…”

“…Subgroups of anhedonic and resilient rats were randomly allocated to the various investigations (33,34). Two subgroups were assigned to the studies reported here, together with an unchallenged control group (control, n = 12; anhedonic, n = 12; resilient, n = 12).…”

Diabetes to cardiovascular disease: Is depression the potential missing link?

“…Even a moderate increase in depressive symptoms is considered to affect endothelial dysfunction [19,20], which has also been observed in diabetic subjects with remitted major depressive disorder (MDD) [21]. Pathophysiological relationship of depression for the risk of CVD showed that in depressed patients, platelet aggregation is significantly enhanced with increased expression of glycoprotein-1b (Gp1B), fibrinogen, factor V and anionic phospholipids [22].…”

Depression, Vascular Conditions and Chronicity

“…Studies investigating the association between depression and arteriosclerosis have used a variety of indexes for vascular function (Lavoie et al 2010;Oulis et al 2010;Paranthaman et al 2010;Rajagopalan et al 2001;Rybakowski et al 2006;Sherwood et al 2005;Tiemeier et al 2003). Irrespective of these different outcome measures, all studies unanimously have shown depressed individuals to have impaired endothelial function or increased arterial stiffness.…”